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Viral persistence in colorectal cancer cells infected by Newcastle disease virus

Background Newcastle disease virus (NDV), a single-stranded RNA virus of the family Paramyxoviridae, is a candidate virotherapy agent in cancer treatment. Promising responses were observed in clinical studies. Despite its high potential, the possibility of the virus to develop a persistent form of...

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Main Authors: Chia, Suet Lin, Yusoff, Khatijah, Shafee, Norazizah
Format: Article
Language:English
Published: BioMed Central 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35987/1/Viral%20persistence%20in%20colorectal%20cancer%20cells.pdf
http://psasir.upm.edu.my/id/eprint/35987/
http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-11-91
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spelling my.upm.eprints.359872016-02-12T07:19:56Z http://psasir.upm.edu.my/id/eprint/35987/ Viral persistence in colorectal cancer cells infected by Newcastle disease virus Chia, Suet Lin Yusoff, Khatijah Shafee, Norazizah Background Newcastle disease virus (NDV), a single-stranded RNA virus of the family Paramyxoviridae, is a candidate virotherapy agent in cancer treatment. Promising responses were observed in clinical studies. Despite its high potential, the possibility of the virus to develop a persistent form of infection in cancer cells has not been investigated. Occurrence of persistent infection by NDV in cancer cells may cause the cells to be less susceptible to the virus killing. This would give rise to a population of cancer cells that remains viable and resistant to treatment. Results During infection experiment in a series of colorectal cancer cell lines, we adventitiously observed a development of persistent infection by NDV in SW480 cells, but not in other cell lines tested. This cell population, designated as SW480P, showed resistancy towards NDV killing in a re-infection experiment. The SW480P cells retained NDV genome and produced virus progeny with reduced plaque forming ability. Conclusion These observations showed that NDV could develop persistent infection in cancer cells and this factor needs to be taken into consideration when using NDV in clinical settings. BioMed Central 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35987/1/Viral%20persistence%20in%20colorectal%20cancer%20cells.pdf Chia, Suet Lin and Yusoff, Khatijah and Shafee, Norazizah (2014) Viral persistence in colorectal cancer cells infected by Newcastle disease virus. Virology Journal, 11. art. no. 91. pp. 1-8. ISSN 1743-422X http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-11-91 10.1186/1743-422X-11-91
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background Newcastle disease virus (NDV), a single-stranded RNA virus of the family Paramyxoviridae, is a candidate virotherapy agent in cancer treatment. Promising responses were observed in clinical studies. Despite its high potential, the possibility of the virus to develop a persistent form of infection in cancer cells has not been investigated. Occurrence of persistent infection by NDV in cancer cells may cause the cells to be less susceptible to the virus killing. This would give rise to a population of cancer cells that remains viable and resistant to treatment. Results During infection experiment in a series of colorectal cancer cell lines, we adventitiously observed a development of persistent infection by NDV in SW480 cells, but not in other cell lines tested. This cell population, designated as SW480P, showed resistancy towards NDV killing in a re-infection experiment. The SW480P cells retained NDV genome and produced virus progeny with reduced plaque forming ability. Conclusion These observations showed that NDV could develop persistent infection in cancer cells and this factor needs to be taken into consideration when using NDV in clinical settings.
format Article
author Chia, Suet Lin
Yusoff, Khatijah
Shafee, Norazizah
spellingShingle Chia, Suet Lin
Yusoff, Khatijah
Shafee, Norazizah
Viral persistence in colorectal cancer cells infected by Newcastle disease virus
author_facet Chia, Suet Lin
Yusoff, Khatijah
Shafee, Norazizah
author_sort Chia, Suet Lin
title Viral persistence in colorectal cancer cells infected by Newcastle disease virus
title_short Viral persistence in colorectal cancer cells infected by Newcastle disease virus
title_full Viral persistence in colorectal cancer cells infected by Newcastle disease virus
title_fullStr Viral persistence in colorectal cancer cells infected by Newcastle disease virus
title_full_unstemmed Viral persistence in colorectal cancer cells infected by Newcastle disease virus
title_sort viral persistence in colorectal cancer cells infected by newcastle disease virus
publisher BioMed Central
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35987/1/Viral%20persistence%20in%20colorectal%20cancer%20cells.pdf
http://psasir.upm.edu.my/id/eprint/35987/
http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-11-91
_version_ 1643831615514738688
score 13.211869

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