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Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method

The switching time to change from adsorption to desorption in liquid chromatography, which is the time at which the concentration of the effluent reaches the breakthrough value, is important in the operation, scale-up, and optimisation of chromatographic separation. The switching time can be estima...

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Main Authors: Wan Daud, Wan Ramli, Myint, San, Mohamad, Abu Bakar, Kadhum, Abdul Amir Hassan
Format: Article
Language:English
English
Published: Universiti Putra Malaysia Press 2000
Online Access:http://psasir.upm.edu.my/id/eprint/3571/1/Prediction_of_Chromatographic_Separation_of_Eugenol.pdf
http://psasir.upm.edu.my/id/eprint/3571/
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spelling my.upm.eprints.35712013-05-27T07:09:33Z http://psasir.upm.edu.my/id/eprint/3571/ Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method Wan Daud, Wan Ramli Myint, San Mohamad, Abu Bakar Kadhum, Abdul Amir Hassan The switching time to change from adsorption to desorption in liquid chromatography, which is the time at which the concentration of the effluent reaches the breakthrough value, is important in the operation, scale-up, and optimisation of chromatographic separation. The switching time can be estimated by computer simulation of the chromatographic adsorption column. In this paper, the theoretical simulation of the chromatographic column of Chen and Hsu (1987) based on the Fast Fourier Transform (FFT) method originally proposed for chromatographic systems by Hsu using estimated axial diffusivity, film mass transfer coefficient and pore diffusivity obtained from analytical scale separation, is compared with experimental data of chromatographic separation of eugenol. The use of FIT over more sophisticated techniques such as finite difference or orthogonal collocation methods was dictated by the simpler computation and the availability of better inverting techniques. The model was validated by experimental data on chromatographic separation of eugenol on IBondapak CIS analytical column, mobile phase methanol-water (80:20), and flow rate 0.5 ml/min, at different solution concentration injection at equilibrium condition. Physical property data required for validation such as equilibrium adsorption isotherm data was determined experimentally, and mass transfer data was calculated from normal correlations and from analytical scale separation. The simulation agreed with experimental data at a Peclet number of 6000, a bed length parameter of 3.0 and number of samples 90. Universiti Putra Malaysia Press 2000 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/3571/1/Prediction_of_Chromatographic_Separation_of_Eugenol.pdf Wan Daud, Wan Ramli and Myint, San and Mohamad, Abu Bakar and Kadhum, Abdul Amir Hassan (2000) Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method. Pertanika Journal of Science & Technology, 8 (2). pp. 217-227. ISSN 0128-7680 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description The switching time to change from adsorption to desorption in liquid chromatography, which is the time at which the concentration of the effluent reaches the breakthrough value, is important in the operation, scale-up, and optimisation of chromatographic separation. The switching time can be estimated by computer simulation of the chromatographic adsorption column. In this paper, the theoretical simulation of the chromatographic column of Chen and Hsu (1987) based on the Fast Fourier Transform (FFT) method originally proposed for chromatographic systems by Hsu using estimated axial diffusivity, film mass transfer coefficient and pore diffusivity obtained from analytical scale separation, is compared with experimental data of chromatographic separation of eugenol. The use of FIT over more sophisticated techniques such as finite difference or orthogonal collocation methods was dictated by the simpler computation and the availability of better inverting techniques. The model was validated by experimental data on chromatographic separation of eugenol on IBondapak CIS analytical column, mobile phase methanol-water (80:20), and flow rate 0.5 ml/min, at different solution concentration injection at equilibrium condition. Physical property data required for validation such as equilibrium adsorption isotherm data was determined experimentally, and mass transfer data was calculated from normal correlations and from analytical scale separation. The simulation agreed with experimental data at a Peclet number of 6000, a bed length parameter of 3.0 and number of samples 90.
format Article
author Wan Daud, Wan Ramli
Myint, San
Mohamad, Abu Bakar
Kadhum, Abdul Amir Hassan
spellingShingle Wan Daud, Wan Ramli
Myint, San
Mohamad, Abu Bakar
Kadhum, Abdul Amir Hassan
Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
author_facet Wan Daud, Wan Ramli
Myint, San
Mohamad, Abu Bakar
Kadhum, Abdul Amir Hassan
author_sort Wan Daud, Wan Ramli
title Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
title_short Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
title_full Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
title_fullStr Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
title_full_unstemmed Prediction of Chromatographic Separation of Eugenol by the Fast Fourier Transform Method
title_sort prediction of chromatographic separation of eugenol by the fast fourier transform method
publisher Universiti Putra Malaysia Press
publishDate 2000
url http://psasir.upm.edu.my/id/eprint/3571/1/Prediction_of_Chromatographic_Separation_of_Eugenol.pdf
http://psasir.upm.edu.my/id/eprint/3571/
_version_ 1643822649775751168
score 13.211869

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