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Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract

Objective(s):This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by fi...

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Main Authors: Parhizkar, Saadat, Zulkifli, Suriani, Dollah , Mohammad Aziz
Format: Article
Published: Mashhad University of Medical Sciences 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35617/
http://ijbms.mums.ac.ir/issue_391_461_Volume+17%2C+Issue+5%2C+May+2014%2C+Page+312-395.html
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spelling my.upm.eprints.356172016-01-18T02:49:06Z http://psasir.upm.edu.my/id/eprint/35617/ Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract Parhizkar, Saadat Zulkifli, Suriani Dollah , Mohammad Aziz Objective(s):This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult male rats were divided into three groups (six in each group), designated as treatment (240 mg/kg PM), negative control (distilled water) and positive control (4mg/kg testosterone) and administered via intragastric gavage for seven weeks. In the sixth week of supplementation period, each male rat was introduced to five female rats. Afterward, all rats were sacrificed and the testes were removed for histological studies. Results: PM significantly increased the number of cell and the thickness of seminiferous tubules of male rats (P<0.05). However, there was no significant effect on the volume and size of testes. The mean of spermatogonia cells numbers of PMgroups differed significantly from the negative and positive groups (P<0.05). Conclusion: PM showed potential value as an attractive alternative for improving sexual strength by increasing the number of spermatogonia cell and the thickness of the seminiferous tubules. Perhaps, PM could be suggested to be one of the herbal remedies that can improve men fertility. The results may have some clinical implication in the management of infertility. Mashhad University of Medical Sciences 2014-05 Article PeerReviewed Parhizkar, Saadat and Zulkifli, Suriani and Dollah , Mohammad Aziz (2014) Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract. Iranian Journal of Basic Medical Sciences, 17 (5). pp. 384-390. ISSN 2008-3866; ESSN: 2008-3874 http://ijbms.mums.ac.ir/issue_391_461_Volume+17%2C+Issue+5%2C+May+2014%2C+Page+312-395.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Objective(s):This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult male rats were divided into three groups (six in each group), designated as treatment (240 mg/kg PM), negative control (distilled water) and positive control (4mg/kg testosterone) and administered via intragastric gavage for seven weeks. In the sixth week of supplementation period, each male rat was introduced to five female rats. Afterward, all rats were sacrificed and the testes were removed for histological studies. Results: PM significantly increased the number of cell and the thickness of seminiferous tubules of male rats (P<0.05). However, there was no significant effect on the volume and size of testes. The mean of spermatogonia cells numbers of PMgroups differed significantly from the negative and positive groups (P<0.05). Conclusion: PM showed potential value as an attractive alternative for improving sexual strength by increasing the number of spermatogonia cell and the thickness of the seminiferous tubules. Perhaps, PM could be suggested to be one of the herbal remedies that can improve men fertility. The results may have some clinical implication in the management of infertility.
format Article
author Parhizkar, Saadat
Zulkifli, Suriani
Dollah , Mohammad Aziz
spellingShingle Parhizkar, Saadat
Zulkifli, Suriani
Dollah , Mohammad Aziz
Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
author_facet Parhizkar, Saadat
Zulkifli, Suriani
Dollah , Mohammad Aziz
author_sort Parhizkar, Saadat
title Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
title_short Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
title_full Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
title_fullStr Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
title_full_unstemmed Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
title_sort testicular morphology of male rats exposed to phaleria macrocarpa (mahkota dewa) aqueous extract
publisher Mashhad University of Medical Sciences
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35617/
http://ijbms.mums.ac.ir/issue_391_461_Volume+17%2C+Issue+5%2C+May+2014%2C+Page+312-395.html
_version_ 1643831506939936768
score 13.211869

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