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Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid

Carbon nanotubes (CNTs) have been widely utilized as a novel drug carrier with promising future applications in biomedical therapies due to their distinct characteristics. In the present work, carboxylic acid-functionalized single-walled carbon nanotubes (f-SWCNTs) were used as the starting material...

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Main Authors: Tan, Julia Meihua, Govindarajan, Karthivashan, Arulselvan, Palanisamy, Fakurazi, Sharida, Hussein, Mohd. Zobir
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35552/1/Sustained%20Release%20and%20Cytotoxicity%20Evaluation%20of%20Carbon.pdf
http://psasir.upm.edu.my/id/eprint/35552/
http://www.hindawi.com/journals/jnm/2014/862148/abs/
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spelling my.upm.eprints.355522016-01-14T04:58:28Z http://psasir.upm.edu.my/id/eprint/35552/ Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid Tan, Julia Meihua Govindarajan, Karthivashan Arulselvan, Palanisamy Fakurazi, Sharida Hussein, Mohd. Zobir Carbon nanotubes (CNTs) have been widely utilized as a novel drug carrier with promising future applications in biomedical therapies due to their distinct characteristics. In the present work, carboxylic acid-functionalized single-walled carbon nanotubes (f-SWCNTs) were used as the starting material to react with anticancer drug, BA to produce f-SWCNTs-BA conjugate via stacking interaction. The conjugate was extensively characterized for drug loading capacity, physicochemical properties, surface morphology, drug releasing characteristics, and cytotoxicity evaluation. The results indicated that the drug loading capacity was determined to be around 20 wt% and this value has been verified by thermogravimetric analysis. The binding of BA onto the surface of f-SWCNTs was confirmed by FTIR and Raman spectroscopies. Powder XRD analysis showed that the structure of the conjugate was unaffected by the loading of BA. The developed conjugate was found to release the drug in a controlled manner with a prolonged release property. According to the preliminary in vitro cytotoxicity studies, the conjugate was not toxic in a standard fibroblast cell line, and anticancer activity was significantly higher in A549 than HepG2 cell line. This study suggests that f-SWCNTs could be developed as an efficient drug carrier to conjugate drugs for pharmaceutical applications in cancer chemotherapies. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35552/1/Sustained%20Release%20and%20Cytotoxicity%20Evaluation%20of%20Carbon.pdf Tan, Julia Meihua and Govindarajan, Karthivashan and Arulselvan, Palanisamy and Fakurazi, Sharida and Hussein, Mohd. Zobir (2014) Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid. Journal of Nanomaterials, 2014. art. no. 862148. pp. 1-11. ISSN 1687-4110; ESSN: 1687-4129 http://www.hindawi.com/journals/jnm/2014/862148/abs/ 10.1155/2014/862148
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Carbon nanotubes (CNTs) have been widely utilized as a novel drug carrier with promising future applications in biomedical therapies due to their distinct characteristics. In the present work, carboxylic acid-functionalized single-walled carbon nanotubes (f-SWCNTs) were used as the starting material to react with anticancer drug, BA to produce f-SWCNTs-BA conjugate via stacking interaction. The conjugate was extensively characterized for drug loading capacity, physicochemical properties, surface morphology, drug releasing characteristics, and cytotoxicity evaluation. The results indicated that the drug loading capacity was determined to be around 20 wt% and this value has been verified by thermogravimetric analysis. The binding of BA onto the surface of f-SWCNTs was confirmed by FTIR and Raman spectroscopies. Powder XRD analysis showed that the structure of the conjugate was unaffected by the loading of BA. The developed conjugate was found to release the drug in a controlled manner with a prolonged release property. According to the preliminary in vitro cytotoxicity studies, the conjugate was not toxic in a standard fibroblast cell line, and anticancer activity was significantly higher in A549 than HepG2 cell line. This study suggests that f-SWCNTs could be developed as an efficient drug carrier to conjugate drugs for pharmaceutical applications in cancer chemotherapies.
format Article
author Tan, Julia Meihua
Govindarajan, Karthivashan
Arulselvan, Palanisamy
Fakurazi, Sharida
Hussein, Mohd. Zobir
spellingShingle Tan, Julia Meihua
Govindarajan, Karthivashan
Arulselvan, Palanisamy
Fakurazi, Sharida
Hussein, Mohd. Zobir
Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
author_facet Tan, Julia Meihua
Govindarajan, Karthivashan
Arulselvan, Palanisamy
Fakurazi, Sharida
Hussein, Mohd. Zobir
author_sort Tan, Julia Meihua
title Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
title_short Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
title_full Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
title_fullStr Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
title_full_unstemmed Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
title_sort sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid
publisher Hindawi Publishing Corporation
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35552/1/Sustained%20Release%20and%20Cytotoxicity%20Evaluation%20of%20Carbon.pdf
http://psasir.upm.edu.my/id/eprint/35552/
http://www.hindawi.com/journals/jnm/2014/862148/abs/
_version_ 1643831487625166848
score 13.211869

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