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Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes

Background: The US Federal and Drug Administration (FDA) recently revised statin drug labels to include the information that increases in fasting serum glucose and glycated haemoglobin levels have been reported with the use of statins. Yet in a survey, 87% of the doctors stated that they had never o...

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Main Authors: Liew, Su May, Lee, Ping Yein, Hanafi, Nik Sherina Haidi, Ng, Chirk Jenn, Wong, Stalia Siew Lee, Chia, Yook Chin, Lai, Pauline Siew Mei, Mohd Zaidi, Nur Farhana, Khoo, Ee Ming
Format: Article
Language:English
Published: BioMed Central 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35466/1/35466.pdf
http://psasir.upm.edu.my/id/eprint/35466/
https://dmsjournal.biomedcentral.com/articles/10.1186/1758-5996-6-53
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spelling my.upm.eprints.354662019-11-25T06:42:29Z http://psasir.upm.edu.my/id/eprint/35466/ Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes Liew, Su May Lee, Ping Yein Hanafi, Nik Sherina Haidi Ng, Chirk Jenn Wong, Stalia Siew Lee Chia, Yook Chin Lai, Pauline Siew Mei Mohd Zaidi, Nur Farhana Khoo, Ee Ming Background: The US Federal and Drug Administration (FDA) recently revised statin drug labels to include the information that increases in fasting serum glucose and glycated haemoglobin levels have been reported with the use of statins. Yet in a survey, 87% of the doctors stated that they had never or infrequently observed increases in glucose or HbA1c levels in patients on statin. In this study we would like to determine the association between the use of statins and glycaemic control in a retrospective cohort of patients with hypertension. Methods: A retrospective review of 1060 medical records of patients with hypertension at a primary care clinic was conducted. These records were selected using systematic random sampling (1:4). Data on patient socio-demographic factors; clinical profile; investigation results and prescribed medications were collected. Independent t-test was used for continuous variables while Pearson’s χ2 test was used for categorical variables. Logistic regression was done to adjust for confounders. Results: 810 (76.4%) patients with hypertension were on statins, out of which 792 (97.8%) were taking simvastatin 10 mg or 20 mg daily. Analysis of the whole group regardless of diabetes status showed that the statin user group had higher HbA1c and fasting blood glucose values. The difference in HbA1c levels remained significant (adjusted OR = 1.290, p = 0.044, 95% CI 1.006, 1.654) after adjustment for diabetes, diabetic medication and fasting blood glucose. In the study population who had diabetes, statin users again had significantly higher HbA1c level compared to statin non-users. This difference remained significant (adjusted OR 1.208, p = 0.037, 95% CI 1.012, 1.441) after adjustment for age and diabetic medications. Conclusions: Statins use is associated with increased HbA1c levels among hypertensive patients and hypertensive patients with diabetes. Clinicians managing hypertensive patients on statins should consider monitoring the HbA1c level and ensure that those with diabetes have their hyperglycaemia kept under control. BioMed Central 2014 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/35466/1/35466.pdf Liew, Su May and Lee, Ping Yein and Hanafi, Nik Sherina Haidi and Ng, Chirk Jenn and Wong, Stalia Siew Lee and Chia, Yook Chin and Lai, Pauline Siew Mei and Mohd Zaidi, Nur Farhana and Khoo, Ee Ming (2014) Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes. Diabetology & Metabolic Syndrome, 6. art. no. 53. pp. 1-5. ISSN 1758-5996 https://dmsjournal.biomedcentral.com/articles/10.1186/1758-5996-6-53 10.1186/1758-5996-6-53
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: The US Federal and Drug Administration (FDA) recently revised statin drug labels to include the information that increases in fasting serum glucose and glycated haemoglobin levels have been reported with the use of statins. Yet in a survey, 87% of the doctors stated that they had never or infrequently observed increases in glucose or HbA1c levels in patients on statin. In this study we would like to determine the association between the use of statins and glycaemic control in a retrospective cohort of patients with hypertension. Methods: A retrospective review of 1060 medical records of patients with hypertension at a primary care clinic was conducted. These records were selected using systematic random sampling (1:4). Data on patient socio-demographic factors; clinical profile; investigation results and prescribed medications were collected. Independent t-test was used for continuous variables while Pearson’s χ2 test was used for categorical variables. Logistic regression was done to adjust for confounders. Results: 810 (76.4%) patients with hypertension were on statins, out of which 792 (97.8%) were taking simvastatin 10 mg or 20 mg daily. Analysis of the whole group regardless of diabetes status showed that the statin user group had higher HbA1c and fasting blood glucose values. The difference in HbA1c levels remained significant (adjusted OR = 1.290, p = 0.044, 95% CI 1.006, 1.654) after adjustment for diabetes, diabetic medication and fasting blood glucose. In the study population who had diabetes, statin users again had significantly higher HbA1c level compared to statin non-users. This difference remained significant (adjusted OR 1.208, p = 0.037, 95% CI 1.012, 1.441) after adjustment for age and diabetic medications. Conclusions: Statins use is associated with increased HbA1c levels among hypertensive patients and hypertensive patients with diabetes. Clinicians managing hypertensive patients on statins should consider monitoring the HbA1c level and ensure that those with diabetes have their hyperglycaemia kept under control.
format Article
author Liew, Su May
Lee, Ping Yein
Hanafi, Nik Sherina Haidi
Ng, Chirk Jenn
Wong, Stalia Siew Lee
Chia, Yook Chin
Lai, Pauline Siew Mei
Mohd Zaidi, Nur Farhana
Khoo, Ee Ming
spellingShingle Liew, Su May
Lee, Ping Yein
Hanafi, Nik Sherina Haidi
Ng, Chirk Jenn
Wong, Stalia Siew Lee
Chia, Yook Chin
Lai, Pauline Siew Mei
Mohd Zaidi, Nur Farhana
Khoo, Ee Ming
Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
author_facet Liew, Su May
Lee, Ping Yein
Hanafi, Nik Sherina Haidi
Ng, Chirk Jenn
Wong, Stalia Siew Lee
Chia, Yook Chin
Lai, Pauline Siew Mei
Mohd Zaidi, Nur Farhana
Khoo, Ee Ming
author_sort Liew, Su May
title Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
title_short Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
title_full Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
title_fullStr Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
title_full_unstemmed Statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
title_sort statins use is associated with poorer glycaemic control in a cohort of hypertensive patients with diabetes and without diabetes
publisher BioMed Central
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35466/1/35466.pdf
http://psasir.upm.edu.my/id/eprint/35466/
https://dmsjournal.biomedcentral.com/articles/10.1186/1758-5996-6-53
_version_ 1651869046572843008
score 13.211869

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