Cover Image

Metabolism of goniothalamin in animal and microbial system

Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, H...

Full description

Saved in:
Bibliographic Details
Main Authors: El-Sharkawy, Saleh Hassan, Yusuf, Z., Lope Pihie, Azimahtol Hawariah, Ali, Abdul Manaf
Format: Article
Language:English
Published: Societa Editoriale Farmaceutica 1996
Online Access:http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf
http://psasir.upm.edu.my/id/eprint/35035/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.35035
record_format eprints
spelling my.upm.eprints.350352016-04-26T01:53:55Z http://psasir.upm.edu.my/id/eprint/35035/ Metabolism of goniothalamin in animal and microbial system El-Sharkawy, Saleh Hassan Yusuf, Z. Lope Pihie, Azimahtol Hawariah Ali, Abdul Manaf Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, HPLC, MS, IR, and 1H- and 13C-NMR spectroscopy. In addition, the substrate had been transformed into two unknown metabolites by Aspergillus niger ATCC 11394 and Septomyxa affinis ATCC 6737 in low yield. Three of the metabolites were also detected and identified in the urine and blood samples of the goniothalamin-treated Sprague-Dawley rats. The obtained results are in agreement with and support the principle of microbial models of mammalian metabolism. Societa Editoriale Farmaceutica 1996 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf El-Sharkawy, Saleh Hassan and Yusuf, Z. and Lope Pihie, Azimahtol Hawariah and Ali, Abdul Manaf (1996) Metabolism of goniothalamin in animal and microbial system. Bollettino Chimico Farmaceutico, 135 (1). pp. 35-40. ISSN 0006-6648
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Of the twenty microorganisms screened for metabolism of goniothalamin only Streptomyces aurofaciens ATCC 10762 and Nocardia species NRRL 5646 produced two metabolites, 3,4-dihydrogoniothalamin and 3,4,7,8 tetrahydrogoniothalamin. The identity of the isolated metabolites were established using TLC, HPLC, MS, IR, and 1H- and 13C-NMR spectroscopy. In addition, the substrate had been transformed into two unknown metabolites by Aspergillus niger ATCC 11394 and Septomyxa affinis ATCC 6737 in low yield. Three of the metabolites were also detected and identified in the urine and blood samples of the goniothalamin-treated Sprague-Dawley rats. The obtained results are in agreement with and support the principle of microbial models of mammalian metabolism.
format Article
author El-Sharkawy, Saleh Hassan
Yusuf, Z.
Lope Pihie, Azimahtol Hawariah
Ali, Abdul Manaf
spellingShingle El-Sharkawy, Saleh Hassan
Yusuf, Z.
Lope Pihie, Azimahtol Hawariah
Ali, Abdul Manaf
Metabolism of goniothalamin in animal and microbial system
author_facet El-Sharkawy, Saleh Hassan
Yusuf, Z.
Lope Pihie, Azimahtol Hawariah
Ali, Abdul Manaf
author_sort El-Sharkawy, Saleh Hassan
title Metabolism of goniothalamin in animal and microbial system
title_short Metabolism of goniothalamin in animal and microbial system
title_full Metabolism of goniothalamin in animal and microbial system
title_fullStr Metabolism of goniothalamin in animal and microbial system
title_full_unstemmed Metabolism of goniothalamin in animal and microbial system
title_sort metabolism of goniothalamin in animal and microbial system
publisher Societa Editoriale Farmaceutica
publishDate 1996
url http://psasir.upm.edu.my/id/eprint/35035/1/Metabolism%20of%20goniothalamin%20in%20animal%20and%20microbial%20system.pdf
http://psasir.upm.edu.my/id/eprint/35035/
_version_ 1643831333715181568
score 13.211869

Similar Items