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Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system

We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocompo...

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Main Authors: Kura, Aminu Umar, Hussein Al-Ali, Samer Hasan, Hussein, Mohd Zobir, Fakurazi, Sharida
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf
http://psasir.upm.edu.my/id/eprint/35016/
http://www.hindawi.com/journals/tswj/2014/104246/abs/
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spelling my.upm.eprints.350162015-12-28T08:59:32Z http://psasir.upm.edu.my/id/eprint/35016/ Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system Kura, Aminu Umar Hussein Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay). Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf Kura, Aminu Umar and Hussein Al-Ali, Samer Hasan and Hussein, Mohd Zobir and Fakurazi, Sharida (2014) Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system. The Scientific World Journal, 2014. art. no. 104246. pp. 1-10. ISSN 2356-6140; ESSN: 1537-744X http://www.hindawi.com/journals/tswj/2014/104246/abs/ 10.1155/2014/104246
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay).
format Article
author Kura, Aminu Umar
Hussein Al-Ali, Samer Hasan
Hussein, Mohd Zobir
Fakurazi, Sharida
spellingShingle Kura, Aminu Umar
Hussein Al-Ali, Samer Hasan
Hussein, Mohd Zobir
Fakurazi, Sharida
Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
author_facet Kura, Aminu Umar
Hussein Al-Ali, Samer Hasan
Hussein, Mohd Zobir
Fakurazi, Sharida
author_sort Kura, Aminu Umar
title Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
title_short Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
title_full Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
title_fullStr Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
title_full_unstemmed Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
title_sort preparation of tween 80-zn/al-levodopa-layered double hydroxides nanocomposite for drug delivery system
publisher Hindawi Publishing Corporation
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf
http://psasir.upm.edu.my/id/eprint/35016/
http://www.hindawi.com/journals/tswj/2014/104246/abs/
_version_ 1643831328011976704
score 13.211869

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