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Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles

Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Te...

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Main Authors: Mftah, Ae, Alhassan, Fatah H., Al-Qubaisi, Mothanna Sadiq, El Zowalaty, Mohamed Ezzat, Webster, Thomas Jay, Sh-Eldin, Mohammed Ali, Abdullah, Rasedee, Yap, Taufiq Yun Hin, Rashid, Shah Samiur
Format: Article
Language:English
Published: Dove Medical Press 2015
Online Access:http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf
http://psasir.upm.edu.my/id/eprint/34938/
https://www.dovepress.com/physicochemical-properties-cytotoxicity-andnbspantimicrobial-activity--peer-reviewed-article-IJN
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spelling my.upm.eprints.349382016-11-28T02:36:13Z http://psasir.upm.edu.my/id/eprint/34938/ Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles Mftah, Ae Alhassan, Fatah H. Al-Qubaisi, Mothanna Sadiq El Zowalaty, Mohamed Ezzat Webster, Thomas Jay Sh-Eldin, Mohammed Ali Abdullah, Rasedee Yap, Taufiq Yun Hin Rashid, Shah Samiur Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. Dove Medical Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf Mftah, Ae and Alhassan, Fatah H. and Al-Qubaisi, Mothanna Sadiq and El Zowalaty, Mohamed Ezzat and Webster, Thomas Jay and Sh-Eldin, Mohammed Ali and Abdullah, Rasedee and Yap, Taufiq Yun Hin and Rashid, Shah Samiur (2015) Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles. International Journal of Nanomedicine, 10 (1). pp. 765-774. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/physicochemical-properties-cytotoxicity-andnbspantimicrobial-activity--peer-reviewed-article-IJN 10.2147/IJN.S66058
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications.
format Article
author Mftah, Ae
Alhassan, Fatah H.
Al-Qubaisi, Mothanna Sadiq
El Zowalaty, Mohamed Ezzat
Webster, Thomas Jay
Sh-Eldin, Mohammed Ali
Abdullah, Rasedee
Yap, Taufiq Yun Hin
Rashid, Shah Samiur
spellingShingle Mftah, Ae
Alhassan, Fatah H.
Al-Qubaisi, Mothanna Sadiq
El Zowalaty, Mohamed Ezzat
Webster, Thomas Jay
Sh-Eldin, Mohammed Ali
Abdullah, Rasedee
Yap, Taufiq Yun Hin
Rashid, Shah Samiur
Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
author_facet Mftah, Ae
Alhassan, Fatah H.
Al-Qubaisi, Mothanna Sadiq
El Zowalaty, Mohamed Ezzat
Webster, Thomas Jay
Sh-Eldin, Mohammed Ali
Abdullah, Rasedee
Yap, Taufiq Yun Hin
Rashid, Shah Samiur
author_sort Mftah, Ae
title Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
title_short Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
title_full Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
title_fullStr Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
title_full_unstemmed Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
title_sort physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles
publisher Dove Medical Press
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/34938/1/34938.pdf
http://psasir.upm.edu.my/id/eprint/34938/
https://www.dovepress.com/physicochemical-properties-cytotoxicity-andnbspantimicrobial-activity--peer-reviewed-article-IJN
_version_ 1643831304639217664
score 13.211869

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