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Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products

In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pin...

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Main Authors: Gull, Yasmeen, Rasool, Nasir, Noreen, Mnaza, Nasim, Faiz-ul-Hassan, Yaqoob, Asma, Kousar, Shazia, Rashid, Umer, Bukhari, Iftikhar Hussain, Zubair, Muhammad, Islam, Md. Saiful
Format: Article
Language:English
English
Published: Multidisciplinary Digital Publishing Institute 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf
http://psasir.upm.edu.my/id/eprint/30812/
http://www.mdpi.com/1420-3049/18/8
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spelling my.upm.eprints.308122015-10-20T07:39:19Z http://psasir.upm.edu.my/id/eprint/30812/ Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL. Multidisciplinary Digital Publishing Institute 2013-07-25 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf Gull, Yasmeen and Rasool, Nasir and Noreen, Mnaza and Nasim, Faiz-ul-Hassan and Yaqoob, Asma and Kousar, Shazia and Rashid, Umer and Bukhari, Iftikhar Hussain and Zubair, Muhammad and Islam, Md. Saiful (2013) Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products. Molecules, 18 (8). pp. 8845-8857. ISSN 1420-3049 http://www.mdpi.com/1420-3049/18/8 10.3390/molecules18088845 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL.
format Article
author Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
spellingShingle Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
author_facet Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
author_sort Gull, Yasmeen
title Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
title_short Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
title_full Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
title_fullStr Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
title_full_unstemmed Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
title_sort efficient synthesis of 2-amino-6-arylbenzothiazoles via pd(0) suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
publisher Multidisciplinary Digital Publishing Institute
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf
http://psasir.upm.edu.my/id/eprint/30812/
http://www.mdpi.com/1420-3049/18/8
_version_ 1643830171191476224
score 13.211869

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