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Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion

Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem...

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Main Authors: Abdul Rahman, Norizah, Feisst, Vaughan, Dickinson, Michelle E., Malmstrom, Jenny, Dunbar, P. Rod, Travas Sejdic, Jadranka
Format: Article
Language:English
English
Published: Elsevier 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf
http://psasir.upm.edu.my/id/eprint/30165/
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spelling my.upm.eprints.301652015-09-10T08:01:32Z http://psasir.upm.edu.my/id/eprint/30165/ Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion Abdul Rahman, Norizah Feisst, Vaughan Dickinson, Michelle E. Malmstrom, Jenny Dunbar, P. Rod Travas Sejdic, Jadranka Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem cells (hASCs). These polymers, in both conductive and non-conductive form, were electrospun with average fibre diameters of less than 400 nm. Novel nanoindentation results obtained on the individual nanofibres revealed that the elastic moduli of the nanofibres are much higher at the surface (4–10 GPa, hmax <75 nm) than in the inner fibre core (2–4 GPa, hmax >75 nm). The composite nanofibres showed great promise as a scaffold for hASCs as they supported the cell adhesion and proliferation. After 1 week of cell culture hASCs were well spread on the substrates with abundant focal adhesions. The electrospun mats provide the cells with comparably stiff, sub-micron sized fibres as anchoring points on a substrate of high porosity. The conductive nature of these composite nanofibres offers exciting opportunities for electrical stimulation of the cells. Elsevier 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf Abdul Rahman, Norizah and Feisst, Vaughan and Dickinson, Michelle E. and Malmstrom, Jenny and Dunbar, P. Rod and Travas Sejdic, Jadranka (2013) Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion. Materials Chemistry and Physics, 138 (1). pp. 333-341. ISSN 0254-0584 10.1016/j.matchemphys.2012.11.065 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem cells (hASCs). These polymers, in both conductive and non-conductive form, were electrospun with average fibre diameters of less than 400 nm. Novel nanoindentation results obtained on the individual nanofibres revealed that the elastic moduli of the nanofibres are much higher at the surface (4–10 GPa, hmax <75 nm) than in the inner fibre core (2–4 GPa, hmax >75 nm). The composite nanofibres showed great promise as a scaffold for hASCs as they supported the cell adhesion and proliferation. After 1 week of cell culture hASCs were well spread on the substrates with abundant focal adhesions. The electrospun mats provide the cells with comparably stiff, sub-micron sized fibres as anchoring points on a substrate of high porosity. The conductive nature of these composite nanofibres offers exciting opportunities for electrical stimulation of the cells.
format Article
author Abdul Rahman, Norizah
Feisst, Vaughan
Dickinson, Michelle E.
Malmstrom, Jenny
Dunbar, P. Rod
Travas Sejdic, Jadranka
spellingShingle Abdul Rahman, Norizah
Feisst, Vaughan
Dickinson, Michelle E.
Malmstrom, Jenny
Dunbar, P. Rod
Travas Sejdic, Jadranka
Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
author_facet Abdul Rahman, Norizah
Feisst, Vaughan
Dickinson, Michelle E.
Malmstrom, Jenny
Dunbar, P. Rod
Travas Sejdic, Jadranka
author_sort Abdul Rahman, Norizah
title Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
title_short Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
title_full Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
title_fullStr Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
title_full_unstemmed Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
title_sort functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
publisher Elsevier
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf
http://psasir.upm.edu.my/id/eprint/30165/
_version_ 1643829976929140736
score 13.211869

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