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Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.

The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deox...

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Main Authors: Teh, Soek Sin, Ee, Gwendoline Cheng Lian, Mah, Siau Hui, Lim, Yang Mooi, Ahmad, Zuraini
Format: Article
Language:English
English
Published: MDPI 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf
http://psasir.upm.edu.my/id/eprint/30008/
http://www.mdpi.com/1420-3049/18/2
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spelling my.upm.eprints.300082015-12-29T03:54:56Z http://psasir.upm.edu.my/id/eprint/30008/ Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. Teh, Soek Sin Ee, Gwendoline Cheng Lian Mah, Siau Hui Lim, Yang Mooi Ahmad, Zuraini The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities. MDPI 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf Teh, Soek Sin and Ee, Gwendoline Cheng Lian and Mah, Siau Hui and Lim, Yang Mooi and Ahmad, Zuraini (2013) Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. Molecules, 18 (2). pp. 1985-1994. ISSN 1431-5157; ESSN: 1420-3049 http://www.mdpi.com/1420-3049/18/2 10.3390/molecules18021985 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
format Article
author Teh, Soek Sin
Ee, Gwendoline Cheng Lian
Mah, Siau Hui
Lim, Yang Mooi
Ahmad, Zuraini
spellingShingle Teh, Soek Sin
Ee, Gwendoline Cheng Lian
Mah, Siau Hui
Lim, Yang Mooi
Ahmad, Zuraini
Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
author_facet Teh, Soek Sin
Ee, Gwendoline Cheng Lian
Mah, Siau Hui
Lim, Yang Mooi
Ahmad, Zuraini
author_sort Teh, Soek Sin
title Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
title_short Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
title_full Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
title_fullStr Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
title_full_unstemmed Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
title_sort cytotoxicity and structure-activity relationships of xanthone derivatives from mesua beccariana, mesua ferrea and mesua congestiflora towards nine human cancer cell lines.
publisher MDPI
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf
http://psasir.upm.edu.my/id/eprint/30008/
http://www.mdpi.com/1420-3049/18/2
_version_ 1643829929405579264
score 13.211869

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