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Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia

A cross-sectional study was conducted from 10 January to 9 April 2012, to determine the seroprevalence of tuberculosis (TB) of all captive Asian elephants and their handlers in six locations in Peninsular Malaysia. In addition, trunk-wash samples were examined for tubercle bacillus by culture and po...

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Main Authors: Ong, Bee Lee, Ngeow, Yun Fong, Abdul Razak, Mohd Firdaus Ariff, Yusuf, Yakubu, Zakaria, Zunita, Abdul Mutalib, Abdul Rahim, Hassan, Latiffah, Ng, Hien Fuh, Verasahib, Khebir
Format: Article
Language:English
Published: Cambridge University Press 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29865/1/Tuberculosis%20in%20captive%20Asian%20elephants%20%28Elephas%20maximus%29%20in%20Peninsular%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/29865/
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spelling my.upm.eprints.298652016-09-14T04:16:26Z http://psasir.upm.edu.my/id/eprint/29865/ Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia Ong, Bee Lee Ngeow, Yun Fong Abdul Razak, Mohd Firdaus Ariff Yusuf, Yakubu Zakaria, Zunita Abdul Mutalib, Abdul Rahim Hassan, Latiffah Ng, Hien Fuh Verasahib, Khebir A cross-sectional study was conducted from 10 January to 9 April 2012, to determine the seroprevalence of tuberculosis (TB) of all captive Asian elephants and their handlers in six locations in Peninsular Malaysia. In addition, trunk-wash samples were examined for tubercle bacillus by culture and polymerase chain reaction (PCR). For 63 elephants and 149 elephant handlers, TB seroprevalence was estimated at 20·4% and 24·8%, respectively. From 151 trunk-wash samples, 24 acid-fast isolates were obtained, 23 of which were identified by hsp65-based sequencing as non-tuberculous mycobacteria. The Mycobacterium tuberculosis-specific PCR was positive in the trunk-wash samples from three elephants which were also seropositive. Conversely, the trunk wash from seven seropositive elephants were PCR negative. Hence, there was evidence of active and latent TB in the elephants and the high seroprevalence in the elephants and their handlers suggests frequent, close contact, two-way transmission between animals and humans within confined workplaces. Cambridge University Press 2013-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29865/1/Tuberculosis%20in%20captive%20Asian%20elephants%20%28Elephas%20maximus%29%20in%20Peninsular%20Malaysia.pdf Ong, Bee Lee and Ngeow, Yun Fong and Abdul Razak, Mohd Firdaus Ariff and Yusuf, Yakubu and Zakaria, Zunita and Abdul Mutalib, Abdul Rahim and Hassan, Latiffah and Ng, Hien Fuh and Verasahib, Khebir (2013) Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia. Epidemiology and Infection, 141 (spec.7). pp. 1481-1487. ISSN 0950-2688; ESSN: 1469-4409 10.1017/S0950268813000265
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A cross-sectional study was conducted from 10 January to 9 April 2012, to determine the seroprevalence of tuberculosis (TB) of all captive Asian elephants and their handlers in six locations in Peninsular Malaysia. In addition, trunk-wash samples were examined for tubercle bacillus by culture and polymerase chain reaction (PCR). For 63 elephants and 149 elephant handlers, TB seroprevalence was estimated at 20·4% and 24·8%, respectively. From 151 trunk-wash samples, 24 acid-fast isolates were obtained, 23 of which were identified by hsp65-based sequencing as non-tuberculous mycobacteria. The Mycobacterium tuberculosis-specific PCR was positive in the trunk-wash samples from three elephants which were also seropositive. Conversely, the trunk wash from seven seropositive elephants were PCR negative. Hence, there was evidence of active and latent TB in the elephants and the high seroprevalence in the elephants and their handlers suggests frequent, close contact, two-way transmission between animals and humans within confined workplaces.
format Article
author Ong, Bee Lee
Ngeow, Yun Fong
Abdul Razak, Mohd Firdaus Ariff
Yusuf, Yakubu
Zakaria, Zunita
Abdul Mutalib, Abdul Rahim
Hassan, Latiffah
Ng, Hien Fuh
Verasahib, Khebir
spellingShingle Ong, Bee Lee
Ngeow, Yun Fong
Abdul Razak, Mohd Firdaus Ariff
Yusuf, Yakubu
Zakaria, Zunita
Abdul Mutalib, Abdul Rahim
Hassan, Latiffah
Ng, Hien Fuh
Verasahib, Khebir
Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
author_facet Ong, Bee Lee
Ngeow, Yun Fong
Abdul Razak, Mohd Firdaus Ariff
Yusuf, Yakubu
Zakaria, Zunita
Abdul Mutalib, Abdul Rahim
Hassan, Latiffah
Ng, Hien Fuh
Verasahib, Khebir
author_sort Ong, Bee Lee
title Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
title_short Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
title_full Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
title_fullStr Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
title_full_unstemmed Tuberculosis in captive Asian elephants (Elephas maximus) in Peninsular Malaysia
title_sort tuberculosis in captive asian elephants (elephas maximus) in peninsular malaysia
publisher Cambridge University Press
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29865/1/Tuberculosis%20in%20captive%20Asian%20elephants%20%28Elephas%20maximus%29%20in%20Peninsular%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/29865/
_version_ 1643829887744606208
score 13.211869

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