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Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology

African-born Australians are a recognised "priority population" in Australia's Sixth National HIV/AIDS Strategy. We compared exposure location and route for African-born people living with HIV (PLHIV) in Victoria, Australia, with HIV-1 pol subtype from drug resistance assays and geogr...

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Main Authors: Lemoh, Chris Numa, Ryan, Claire E., Sekawi, Zamberi, Hearps, Anna C., Aleksic, Eman, Chibo, Doris, Grierson, Jeffrey W., Baho, Samia, Street, Alan C., Hellard, Margaret Elena, Biggs, Beverley Ann, Crowe, Suzanne M.
Format: Article
Language:English
Published: Public Library of Science 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29821/1/Acquisition%20of%20HIV%20by%20African.pdf
http://psasir.upm.edu.my/id/eprint/29821/
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spelling my.upm.eprints.298212015-10-01T03:32:08Z http://psasir.upm.edu.my/id/eprint/29821/ Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology Lemoh, Chris Numa Ryan, Claire E. Sekawi, Zamberi Hearps, Anna C. Aleksic, Eman Chibo, Doris Grierson, Jeffrey W. Baho, Samia Street, Alan C. Hellard, Margaret Elena Biggs, Beverley Ann Crowe, Suzanne M. African-born Australians are a recognised "priority population" in Australia's Sixth National HIV/AIDS Strategy. We compared exposure location and route for African-born people living with HIV (PLHIV) in Victoria, Australia, with HIV-1 pol subtype from drug resistance assays and geographical origin suggested by phylogenetic analysis of env gene. Twenty adult HIV positive African-born Victorian residents were recruited via treating doctors. HIV exposure details were obtained from interviews and case notes. Viral RNA was extracted from participant stored plasma or whole blood. The env V3 region was sequenced and compared to globally representative reference HIV-1 sequences in the Los Alamos National Library HIV Database. Twelve participants reported exposure via heterosexual sex and two via iatrogenic blood exposures; four were men having sex with men (MSM); two were exposed via unknown routes. Eight participants reported exposure in their countries of birth, seven in Australia, three in other countries and two in unknown locations. Genotype results (pol) were available for ten participants. HIV env amplification was successful in eighteen cases. HIV-1 subtype was identified in all participants: eight both pol and env; ten env alone and two pol alone. Twelve were subtype C, four subtype B, three subtype A and one subtype CRF02-AG. Reported exposure location was consistent with the phylogenetic clustering of env sequences. African Australians are members of multiple transnational social and sexual networks influencing their exposure to HIV. Phylogenetic analysis may complement traditional surveillance to discern patterns of HIV exposure, providing focus for HIV prevention programs in mobile populations. Public Library of Science 2013-12-31 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29821/1/Acquisition%20of%20HIV%20by%20African.pdf Lemoh, Chris Numa and Ryan, Claire E. and Sekawi, Zamberi and Hearps, Anna C. and Aleksic, Eman and Chibo, Doris and Grierson, Jeffrey W. and Baho, Samia and Street, Alan C. and Hellard, Margaret Elena and Biggs, Beverley Ann and Crowe, Suzanne M. (2013) Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology. PLOS ONE, 8 (12). art. no. e84008. pp. 1-10. ISSN 1932-6203 10.1371/journal.pone.0084008
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description African-born Australians are a recognised "priority population" in Australia's Sixth National HIV/AIDS Strategy. We compared exposure location and route for African-born people living with HIV (PLHIV) in Victoria, Australia, with HIV-1 pol subtype from drug resistance assays and geographical origin suggested by phylogenetic analysis of env gene. Twenty adult HIV positive African-born Victorian residents were recruited via treating doctors. HIV exposure details were obtained from interviews and case notes. Viral RNA was extracted from participant stored plasma or whole blood. The env V3 region was sequenced and compared to globally representative reference HIV-1 sequences in the Los Alamos National Library HIV Database. Twelve participants reported exposure via heterosexual sex and two via iatrogenic blood exposures; four were men having sex with men (MSM); two were exposed via unknown routes. Eight participants reported exposure in their countries of birth, seven in Australia, three in other countries and two in unknown locations. Genotype results (pol) were available for ten participants. HIV env amplification was successful in eighteen cases. HIV-1 subtype was identified in all participants: eight both pol and env; ten env alone and two pol alone. Twelve were subtype C, four subtype B, three subtype A and one subtype CRF02-AG. Reported exposure location was consistent with the phylogenetic clustering of env sequences. African Australians are members of multiple transnational social and sexual networks influencing their exposure to HIV. Phylogenetic analysis may complement traditional surveillance to discern patterns of HIV exposure, providing focus for HIV prevention programs in mobile populations.
format Article
author Lemoh, Chris Numa
Ryan, Claire E.
Sekawi, Zamberi
Hearps, Anna C.
Aleksic, Eman
Chibo, Doris
Grierson, Jeffrey W.
Baho, Samia
Street, Alan C.
Hellard, Margaret Elena
Biggs, Beverley Ann
Crowe, Suzanne M.
spellingShingle Lemoh, Chris Numa
Ryan, Claire E.
Sekawi, Zamberi
Hearps, Anna C.
Aleksic, Eman
Chibo, Doris
Grierson, Jeffrey W.
Baho, Samia
Street, Alan C.
Hellard, Margaret Elena
Biggs, Beverley Ann
Crowe, Suzanne M.
Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
author_facet Lemoh, Chris Numa
Ryan, Claire E.
Sekawi, Zamberi
Hearps, Anna C.
Aleksic, Eman
Chibo, Doris
Grierson, Jeffrey W.
Baho, Samia
Street, Alan C.
Hellard, Margaret Elena
Biggs, Beverley Ann
Crowe, Suzanne M.
author_sort Lemoh, Chris Numa
title Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
title_short Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
title_full Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
title_fullStr Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
title_full_unstemmed Acquisition of HIV by African-born residents of Victoria, Australia : insights from molecular epidemiology
title_sort acquisition of hiv by african-born residents of victoria, australia : insights from molecular epidemiology
publisher Public Library of Science
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29821/1/Acquisition%20of%20HIV%20by%20African.pdf
http://psasir.upm.edu.my/id/eprint/29821/
_version_ 1643829874841878528
score 13.211869

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