Cover Image

Xanthones from Calophyllum gracilipes and their cytotoxic activity.

Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigm...

Full description

Saved in:
Bibliographic Details
Main Authors: Mad Nasir, Nadiah, Rahmani, Mawardi, Shaari, Khozirah, Kassim, Nur Kartinee, Go, Rusea, Stanslas, Johnson, Jeyaraj, Ethel Jeyaseela
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf
http://psasir.upm.edu.my/id/eprint/29812/
http://www.ukm.my/jsm/english_journals/vol42num9_2013/contentsVol42num9_2013.html
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.29812
record_format eprints
spelling my.upm.eprints.298122015-10-07T06:24:51Z http://psasir.upm.edu.my/id/eprint/29812/ Xanthones from Calophyllum gracilipes and their cytotoxic activity. Mad Nasir, Nadiah Rahmani, Mawardi Shaari, Khozirah Kassim, Nur Kartinee Go, Rusea Stanslas, Johnson Jeyaraj, Ethel Jeyaseela Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf Mad Nasir, Nadiah and Rahmani, Mawardi and Shaari, Khozirah and Kassim, Nur Kartinee and Go, Rusea and Stanslas, Johnson and Jeyaraj, Ethel Jeyaseela (2013) Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0026-6039 http://www.ukm.my/jsm/english_journals/vol42num9_2013/contentsVol42num9_2013.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM.
format Article
author Mad Nasir, Nadiah
Rahmani, Mawardi
Shaari, Khozirah
Kassim, Nur Kartinee
Go, Rusea
Stanslas, Johnson
Jeyaraj, Ethel Jeyaseela
spellingShingle Mad Nasir, Nadiah
Rahmani, Mawardi
Shaari, Khozirah
Kassim, Nur Kartinee
Go, Rusea
Stanslas, Johnson
Jeyaraj, Ethel Jeyaseela
Xanthones from Calophyllum gracilipes and their cytotoxic activity.
author_facet Mad Nasir, Nadiah
Rahmani, Mawardi
Shaari, Khozirah
Kassim, Nur Kartinee
Go, Rusea
Stanslas, Johnson
Jeyaraj, Ethel Jeyaseela
author_sort Mad Nasir, Nadiah
title Xanthones from Calophyllum gracilipes and their cytotoxic activity.
title_short Xanthones from Calophyllum gracilipes and their cytotoxic activity.
title_full Xanthones from Calophyllum gracilipes and their cytotoxic activity.
title_fullStr Xanthones from Calophyllum gracilipes and their cytotoxic activity.
title_full_unstemmed Xanthones from Calophyllum gracilipes and their cytotoxic activity.
title_sort xanthones from calophyllum gracilipes and their cytotoxic activity.
publisher Universiti Kebangsaan Malaysia
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29812/1/Xanthones%20from%20Calophyllum%20gracilipes%20and%20their%20cytotoxic%20activity.pdf
http://psasir.upm.edu.my/id/eprint/29812/
http://www.ukm.my/jsm/english_journals/vol42num9_2013/contentsVol42num9_2013.html
_version_ 1643829872186884096
score 13.211869

Similar Items