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Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals

Aim of study: To determine the clinical and epidemiological characteristics of patients seen with primary immunodeficiencies referred at four Malaysian Hospitals between 1987 to 2007 Methods: Patient data were retrospectively obtained from patient records and supplemented by information from a stand...

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Main Authors: Mohd Noh, Lokman, Nasuruddin, B. A., Abdul Latiff, Amir Hamzah, Md Noah, Rahim, Kamarul Azahar, M. R., Mohamed Zainudin, Norzila, Ismail, Zulkifli, Gill, Harvindar Kaur, Nik Ismail, Nik Zainal Abidin, Suhaimi, A. W. M., Nik Yusoff, Nik Khairulddin, Che Hussin, Che Maraina, Ismail, Intan Hakimah, Mat, I., M., Shahnaz, Omar, Azizi
Format: Article
Language:English
Published: Malaysian Medical Association 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29720/1/Clinical-epidemiological%20pattern%20of%20primary%20immunodeficiencies%20in%20Malaysia%201987-2006%20a%2020%20year%20experience%20in%20four%20Malaysian%20hospitals.pdf
http://psasir.upm.edu.my/id/eprint/29720/
http://www.e-mjm.org/2013/v68n1/index.html
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spelling my.upm.eprints.297202016-08-03T03:37:36Z http://psasir.upm.edu.my/id/eprint/29720/ Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals Mohd Noh, Lokman Nasuruddin, B. A. Abdul Latiff, Amir Hamzah Md Noah, Rahim Kamarul Azahar, M. R. Mohamed Zainudin, Norzila Ismail, Zulkifli Gill, Harvindar Kaur Nik Ismail, Nik Zainal Abidin Suhaimi, A. W. M. Nik Yusoff, Nik Khairulddin Che Hussin, Che Maraina Ismail, Intan Hakimah Mat, I. M., Shahnaz Omar, Azizi Aim of study: To determine the clinical and epidemiological characteristics of patients seen with primary immunodeficiencies referred at four Malaysian Hospitals between 1987 to 2007 Methods: Patient data were retrospectively obtained from patient records and supplemented by information from a standardized questionnaires taken at the time of diagnosis from 4 participating hospitals. The completed data were transferred to document records kept by the first author. The diagnoses made were based on criteria set by WHO Scientific Committee 1986. Results: Fifty one (51) patients with completed records satisfied the criteria of primary immunodeficiencies based on WHO Scientific Committee 1986. Predominant Antibody deficiency (40.4%) is the commonest of the class of primary immunodeficiency (based on modified IUIS classification) followed by phagocytic defect (17.3%), combined immunodeficiencies (15.4%) and other cellular immunodeficiencies (11.5%). The commonest clinical presentation is pneumonia (54%). A positive Family history with a close family relative afflicted was a strong pointer to diagnosis for PID (52.6%) Primary immnodeficiencies are seen in all the major ethnic groups of Malaysia, predominantly among Malays. As observed in other patient registries, diagnostic delay remains the major cause of morbidity and mortality. Conclusion: Primary immunodeficiencies is relative rare but is an emerging disease in Malaysia. Creating awareness of the disease, may reveal more cases within the community. It is sufficient to be a health issue in Malaysia as in other developing countries in the future. Malaysian Medical Association 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29720/1/Clinical-epidemiological%20pattern%20of%20primary%20immunodeficiencies%20in%20Malaysia%201987-2006%20a%2020%20year%20experience%20in%20four%20Malaysian%20hospitals.pdf Mohd Noh, Lokman and Nasuruddin, B. A. and Abdul Latiff, Amir Hamzah and Md Noah, Rahim and Kamarul Azahar, M. R. and Mohamed Zainudin, Norzila and Ismail, Zulkifli and Gill, Harvindar Kaur and Nik Ismail, Nik Zainal Abidin and Suhaimi, A. W. M. and Nik Yusoff, Nik Khairulddin and Che Hussin, Che Maraina and Ismail, Intan Hakimah and Mat, I. and M., Shahnaz and Omar, Azizi (2013) Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals. Medical Journal of Malaysia, 68 (1). pp. 13-17. ISSN 0300-5283 http://www.e-mjm.org/2013/v68n1/index.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Aim of study: To determine the clinical and epidemiological characteristics of patients seen with primary immunodeficiencies referred at four Malaysian Hospitals between 1987 to 2007 Methods: Patient data were retrospectively obtained from patient records and supplemented by information from a standardized questionnaires taken at the time of diagnosis from 4 participating hospitals. The completed data were transferred to document records kept by the first author. The diagnoses made were based on criteria set by WHO Scientific Committee 1986. Results: Fifty one (51) patients with completed records satisfied the criteria of primary immunodeficiencies based on WHO Scientific Committee 1986. Predominant Antibody deficiency (40.4%) is the commonest of the class of primary immunodeficiency (based on modified IUIS classification) followed by phagocytic defect (17.3%), combined immunodeficiencies (15.4%) and other cellular immunodeficiencies (11.5%). The commonest clinical presentation is pneumonia (54%). A positive Family history with a close family relative afflicted was a strong pointer to diagnosis for PID (52.6%) Primary immnodeficiencies are seen in all the major ethnic groups of Malaysia, predominantly among Malays. As observed in other patient registries, diagnostic delay remains the major cause of morbidity and mortality. Conclusion: Primary immunodeficiencies is relative rare but is an emerging disease in Malaysia. Creating awareness of the disease, may reveal more cases within the community. It is sufficient to be a health issue in Malaysia as in other developing countries in the future.
format Article
author Mohd Noh, Lokman
Nasuruddin, B. A.
Abdul Latiff, Amir Hamzah
Md Noah, Rahim
Kamarul Azahar, M. R.
Mohamed Zainudin, Norzila
Ismail, Zulkifli
Gill, Harvindar Kaur
Nik Ismail, Nik Zainal Abidin
Suhaimi, A. W. M.
Nik Yusoff, Nik Khairulddin
Che Hussin, Che Maraina
Ismail, Intan Hakimah
Mat, I.
M., Shahnaz
Omar, Azizi
spellingShingle Mohd Noh, Lokman
Nasuruddin, B. A.
Abdul Latiff, Amir Hamzah
Md Noah, Rahim
Kamarul Azahar, M. R.
Mohamed Zainudin, Norzila
Ismail, Zulkifli
Gill, Harvindar Kaur
Nik Ismail, Nik Zainal Abidin
Suhaimi, A. W. M.
Nik Yusoff, Nik Khairulddin
Che Hussin, Che Maraina
Ismail, Intan Hakimah
Mat, I.
M., Shahnaz
Omar, Azizi
Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
author_facet Mohd Noh, Lokman
Nasuruddin, B. A.
Abdul Latiff, Amir Hamzah
Md Noah, Rahim
Kamarul Azahar, M. R.
Mohamed Zainudin, Norzila
Ismail, Zulkifli
Gill, Harvindar Kaur
Nik Ismail, Nik Zainal Abidin
Suhaimi, A. W. M.
Nik Yusoff, Nik Khairulddin
Che Hussin, Che Maraina
Ismail, Intan Hakimah
Mat, I.
M., Shahnaz
Omar, Azizi
author_sort Mohd Noh, Lokman
title Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
title_short Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
title_full Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
title_fullStr Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
title_full_unstemmed Clinical-epidemiological pattern of primary immunodeficiencies in Malaysia 1987-2006: a 20 year experience in four Malaysian hospitals
title_sort clinical-epidemiological pattern of primary immunodeficiencies in malaysia 1987-2006: a 20 year experience in four malaysian hospitals
publisher Malaysian Medical Association
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29720/1/Clinical-epidemiological%20pattern%20of%20primary%20immunodeficiencies%20in%20Malaysia%201987-2006%20a%2020%20year%20experience%20in%20four%20Malaysian%20hospitals.pdf
http://psasir.upm.edu.my/id/eprint/29720/
http://www.e-mjm.org/2013/v68n1/index.html
_version_ 1643829844819050496
score 13.211869

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