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Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy

INTRODUCTION: The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. OBJECTIVE: We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitiz...

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Main Authors: Ismail, Intan Hakimah, Licciardi, Paul V., Oppedisano, Frances, Boyle, Robert J., Tang, Mimi L. K.
Format: Article
Language:English
Published: Wiley-Blackwell Publishing 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29719/1/Relationship%20between%20breast%20milk%20sCD14.pdf
http://psasir.upm.edu.my/id/eprint/29719/
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spelling my.upm.eprints.297192015-09-21T01:57:11Z http://psasir.upm.edu.my/id/eprint/29719/ Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy Ismail, Intan Hakimah Licciardi, Paul V. Oppedisano, Frances Boyle, Robert J. Tang, Mimi L. K. INTRODUCTION: The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. OBJECTIVE: We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life. METHODS: Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous-phase breast milk samples were assayed for TGF-β1, sCD14 and total IgA. Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF-β1, sCD14 and total IgA were compared in infants who subsequently developed eczema and sensitization in the first year and those who did not. RESULTS: The levels of breast milk sCD14, total IgA, and TGF-β1 at either day 7 or 28 were not associated with subsequent development of eczema or atopic sensitization during the first year of life. CONCLUSION: Levels of breast milk immune parameters were not associated with eczema outcomes or sensitization in infants at 12 months. This suggests that apparent immunological effects on breast milk immunomodulatory factors may not necessarily lead to clinical benefits, and these immune markers may not be critical determinants of allergic disease in infancy. Wiley-Blackwell Publishing 2013-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29719/1/Relationship%20between%20breast%20milk%20sCD14.pdf Ismail, Intan Hakimah and Licciardi, Paul V. and Oppedisano, Frances and Boyle, Robert J. and Tang, Mimi L. K. (2013) Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy. Pediatric Allergy and Immunology, 24 (4). pp. 352-360. ISSN 0905-6157; ESSN: 1399-3038 10.1111/pai.12075
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description INTRODUCTION: The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. OBJECTIVE: We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life. METHODS: Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous-phase breast milk samples were assayed for TGF-β1, sCD14 and total IgA. Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF-β1, sCD14 and total IgA were compared in infants who subsequently developed eczema and sensitization in the first year and those who did not. RESULTS: The levels of breast milk sCD14, total IgA, and TGF-β1 at either day 7 or 28 were not associated with subsequent development of eczema or atopic sensitization during the first year of life. CONCLUSION: Levels of breast milk immune parameters were not associated with eczema outcomes or sensitization in infants at 12 months. This suggests that apparent immunological effects on breast milk immunomodulatory factors may not necessarily lead to clinical benefits, and these immune markers may not be critical determinants of allergic disease in infancy.
format Article
author Ismail, Intan Hakimah
Licciardi, Paul V.
Oppedisano, Frances
Boyle, Robert J.
Tang, Mimi L. K.
spellingShingle Ismail, Intan Hakimah
Licciardi, Paul V.
Oppedisano, Frances
Boyle, Robert J.
Tang, Mimi L. K.
Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
author_facet Ismail, Intan Hakimah
Licciardi, Paul V.
Oppedisano, Frances
Boyle, Robert J.
Tang, Mimi L. K.
author_sort Ismail, Intan Hakimah
title Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
title_short Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
title_full Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
title_fullStr Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
title_full_unstemmed Relationship between breast milk sCD14, TGF-β1 and total IgA in the first month and development of eczema during infancy
title_sort relationship between breast milk scd14, tgf-β1 and total iga in the first month and development of eczema during infancy
publisher Wiley-Blackwell Publishing
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29719/1/Relationship%20between%20breast%20milk%20sCD14.pdf
http://psasir.upm.edu.my/id/eprint/29719/
_version_ 1643829844521254912
score 13.211869

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