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Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract

This study was carried out to evaluate the anti- inflammatory effects of three concentrations of Labisia pumila(Blume)F. Vill-Naves aqueous leaf extract in rats. The effects of these extracts as anti-inflammatory agents were determined using two experiments namely formalin-induced paw licking and c...

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Main Authors: Sanusi, Ruzana Adibah, Ab Shukor, Nor Aini, Sulaiman, Mohd Roslan
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29714/1/Anti%20inflammatory.pdf
http://psasir.upm.edu.my/id/eprint/29714/
http://www.ukm.my/jsm/english_journals/vol42num10_2013/contentsVol42num10_2013.html
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spelling my.upm.eprints.297142018-05-15T06:37:04Z http://psasir.upm.edu.my/id/eprint/29714/ Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract Sanusi, Ruzana Adibah Ab Shukor, Nor Aini Sulaiman, Mohd Roslan This study was carried out to evaluate the anti- inflammatory effects of three concentrations of Labisia pumila(Blume)F. Vill-Naves aqueous leaf extract in rats. The effects of these extracts as anti-inflammatory agents were determined using two experiments namely formalin-induced paw licking and carrageenan-induced paw oedema test. The exposure of inflammation to various treatments resulted in significant differences between treatments in formalin-induced paw licking in rats experiment whereas in phase 2, 50 mg kg-1 of L. pumila extract showed the most significant inhibition of 82.12%, followed by 10 mg kg -1 with 76.00% and 25 mg kg-1 with 57.80%. Similarly, different treatments showed significant effects at p<0.05 in the carrageenan inducing paw oedema experiment. All treatments were able to suppress the oedema formation induced by carrageenan as compared with the control. It is evident that the anti-inflammtory effect of every concentration of L. pumila extract started as early as the first hour of carrageenan injection and showed the maximum inhibition during the fifth hour. Again, 50 mg kg-1 of L. pumila extract was found to be the best treatment that could reduce inflammation with highest inhibition of 64.59% followed by 25 mg kg-1 with 56.99% and 10 mg kg-1 with 5.55%. The result of this study has shown that these extracts of L. pumila can be effective for anti-inflammation purposes which supports and justifies traditional uses of this plant. Penerbit Universiti Kebangsaan Malaysia 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29714/1/Anti%20inflammatory.pdf Sanusi, Ruzana Adibah and Ab Shukor, Nor Aini and Sulaiman, Mohd Roslan (2013) Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract. Sains Malaysiana, 42 (10). pp. 1511-1516. ISSN 0026-6039 http://www.ukm.my/jsm/english_journals/vol42num10_2013/contentsVol42num10_2013.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study was carried out to evaluate the anti- inflammatory effects of three concentrations of Labisia pumila(Blume)F. Vill-Naves aqueous leaf extract in rats. The effects of these extracts as anti-inflammatory agents were determined using two experiments namely formalin-induced paw licking and carrageenan-induced paw oedema test. The exposure of inflammation to various treatments resulted in significant differences between treatments in formalin-induced paw licking in rats experiment whereas in phase 2, 50 mg kg-1 of L. pumila extract showed the most significant inhibition of 82.12%, followed by 10 mg kg -1 with 76.00% and 25 mg kg-1 with 57.80%. Similarly, different treatments showed significant effects at p<0.05 in the carrageenan inducing paw oedema experiment. All treatments were able to suppress the oedema formation induced by carrageenan as compared with the control. It is evident that the anti-inflammtory effect of every concentration of L. pumila extract started as early as the first hour of carrageenan injection and showed the maximum inhibition during the fifth hour. Again, 50 mg kg-1 of L. pumila extract was found to be the best treatment that could reduce inflammation with highest inhibition of 64.59% followed by 25 mg kg-1 with 56.99% and 10 mg kg-1 with 5.55%. The result of this study has shown that these extracts of L. pumila can be effective for anti-inflammation purposes which supports and justifies traditional uses of this plant.
format Article
author Sanusi, Ruzana Adibah
Ab Shukor, Nor Aini
Sulaiman, Mohd Roslan
spellingShingle Sanusi, Ruzana Adibah
Ab Shukor, Nor Aini
Sulaiman, Mohd Roslan
Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
author_facet Sanusi, Ruzana Adibah
Ab Shukor, Nor Aini
Sulaiman, Mohd Roslan
author_sort Sanusi, Ruzana Adibah
title Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
title_short Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
title_full Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
title_fullStr Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
title_full_unstemmed Anti-inflammatory effects of Labisia pumila (Blume) F. Vill-Naves aqueous extract
title_sort anti-inflammatory effects of labisia pumila (blume) f. vill-naves aqueous extract
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29714/1/Anti%20inflammatory.pdf
http://psasir.upm.edu.my/id/eprint/29714/
http://www.ukm.my/jsm/english_journals/vol42num10_2013/contentsVol42num10_2013.html
_version_ 1643829842988236800
score 13.211869

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