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An overview of in vitro research models for Alzheimer`s disease (AD)

Alzheimer’s disease (AD) is the most common form of age-related dementia. It is a neurodegenerative disease characterized by two aberrant features, the amyloid plaques and the neurofibrillary tangles which result in progressive memory loss and cognitive disturbances. This has led to devastating suf...

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Main Authors: Makena Ntimi, Carolindah, Rosli, Rozita, Adam, Aishah, Nordin, Norshariza
Format: Article
Language:English
Published: Tissue Engineering and Regenerative Medicine Society of Malaysia 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29707/1/An%20overview%20of%20in%20vitro%20research%20models%20for%20Alzheimer.pdf
http://psasir.upm.edu.my/id/eprint/29707/
http://regres.tesma.org.my/vol2-2.html
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spelling my.upm.eprints.297072015-10-09T06:53:26Z http://psasir.upm.edu.my/id/eprint/29707/ An overview of in vitro research models for Alzheimer`s disease (AD) Makena Ntimi, Carolindah Rosli, Rozita Adam, Aishah Nordin, Norshariza Alzheimer’s disease (AD) is the most common form of age-related dementia. It is a neurodegenerative disease characterized by two aberrant features, the amyloid plaques and the neurofibrillary tangles which result in progressive memory loss and cognitive disturbances. This has led to devastating suffering to the patient, caregivers, family and economy of the country. As a result, scientists are putting efforts in understanding the mechanisms underlying the development of the disease as well as treatment for the disease. To do so, an ideal model is required that can mimic the development of AD,demonstrating the progressive degeneration of the neurons and formation of amyloid plaques and neurofibrillary tangles. In this review paper, currently available in vitro models for AD will be disc ussed, which include the cancer, primary culture and stem cell lines, highlighting on the benefits and limitations of each. More attention will be focused on the latest established disease-specific induced pluripotent stem cells (iPSCs)isolated from familial AD patients and Dow n syndrome patients. These models have their own advantages and limitations, therefore, more research needs to be done to come up with a model that is suitable not only for fundamental understanding of the disease but also for drug discovery and development. Tissue Engineering and Regenerative Medicine Society of Malaysia 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29707/1/An%20overview%20of%20in%20vitro%20research%20models%20for%20Alzheimer.pdf Makena Ntimi, Carolindah and Rosli, Rozita and Adam, Aishah and Nordin, Norshariza (2013) An overview of in vitro research models for Alzheimer`s disease (AD). Regenerative Research, 2 (2). pp. 8-13. ISSN 2232-0822 http://regres.tesma.org.my/vol2-2.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Alzheimer’s disease (AD) is the most common form of age-related dementia. It is a neurodegenerative disease characterized by two aberrant features, the amyloid plaques and the neurofibrillary tangles which result in progressive memory loss and cognitive disturbances. This has led to devastating suffering to the patient, caregivers, family and economy of the country. As a result, scientists are putting efforts in understanding the mechanisms underlying the development of the disease as well as treatment for the disease. To do so, an ideal model is required that can mimic the development of AD,demonstrating the progressive degeneration of the neurons and formation of amyloid plaques and neurofibrillary tangles. In this review paper, currently available in vitro models for AD will be disc ussed, which include the cancer, primary culture and stem cell lines, highlighting on the benefits and limitations of each. More attention will be focused on the latest established disease-specific induced pluripotent stem cells (iPSCs)isolated from familial AD patients and Dow n syndrome patients. These models have their own advantages and limitations, therefore, more research needs to be done to come up with a model that is suitable not only for fundamental understanding of the disease but also for drug discovery and development.
format Article
author Makena Ntimi, Carolindah
Rosli, Rozita
Adam, Aishah
Nordin, Norshariza
spellingShingle Makena Ntimi, Carolindah
Rosli, Rozita
Adam, Aishah
Nordin, Norshariza
An overview of in vitro research models for Alzheimer`s disease (AD)
author_facet Makena Ntimi, Carolindah
Rosli, Rozita
Adam, Aishah
Nordin, Norshariza
author_sort Makena Ntimi, Carolindah
title An overview of in vitro research models for Alzheimer`s disease (AD)
title_short An overview of in vitro research models for Alzheimer`s disease (AD)
title_full An overview of in vitro research models for Alzheimer`s disease (AD)
title_fullStr An overview of in vitro research models for Alzheimer`s disease (AD)
title_full_unstemmed An overview of in vitro research models for Alzheimer`s disease (AD)
title_sort overview of in vitro research models for alzheimer`s disease (ad)
publisher Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29707/1/An%20overview%20of%20in%20vitro%20research%20models%20for%20Alzheimer.pdf
http://psasir.upm.edu.my/id/eprint/29707/
http://regres.tesma.org.my/vol2-2.html
_version_ 1643829840921493504
score 13.211869

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