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Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss

Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadien...

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Main Authors: Ismail, Salmiah, Jalilian, Farid Azizi, Talebpour, Amir Hossein, Zargar, Mohsen, Shameli, Kamyar, Sekawi, Zamberi, Jahanshiri, Fatemeh
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29655/1/Chemical%20composition%20and%20antibacterial%20and%20cytotoxic%20activities%20of%20Allium%20hirtifolium%20Boiss.pdf
http://psasir.upm.edu.my/id/eprint/29655/
http://dx.doi.org/10.1155/2013/696835
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spelling my.upm.eprints.296552016-02-12T03:54:02Z http://psasir.upm.edu.my/id/eprint/29655/ Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss Ismail, Salmiah Jalilian, Farid Azizi Talebpour, Amir Hossein Zargar, Mohsen Shameli, Kamyar Sekawi, Zamberi Jahanshiri, Fatemeh Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main constituents. The antibacterial activity of the shallot extract was also examined by disk diffusion and microdilution broth assays. It was demonstrated that Persian shallot hydromethanolic extract was effective against 10 different species of pathogenic bacteria including methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, Proteus mirabilis, and Klebsiella pneumoniae. Specifically, the minimum concentration of the extract which inhibited bacterial growth (MIC values) was 1.88 mg/mL for most of the gram-positive bacteria. This concentration was not much different from the concentration that was safe for mammalian cells (1.50 mg/mL) suggesting that the hydromethanolic extract of Persian shallot may be a safe and strong antibacterial agent. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29655/1/Chemical%20composition%20and%20antibacterial%20and%20cytotoxic%20activities%20of%20Allium%20hirtifolium%20Boiss.pdf Ismail, Salmiah and Jalilian, Farid Azizi and Talebpour, Amir Hossein and Zargar, Mohsen and Shameli, Kamyar and Sekawi, Zamberi and Jahanshiri, Fatemeh (2013) Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss. BioMed Research International , 2013. art. no. 696835. pp. 1-8. ISSN 2314-6133; ESSN: 2314-6141 http://dx.doi.org/10.1155/2013/696835 10.1155/2013/696835
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main constituents. The antibacterial activity of the shallot extract was also examined by disk diffusion and microdilution broth assays. It was demonstrated that Persian shallot hydromethanolic extract was effective against 10 different species of pathogenic bacteria including methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, Proteus mirabilis, and Klebsiella pneumoniae. Specifically, the minimum concentration of the extract which inhibited bacterial growth (MIC values) was 1.88 mg/mL for most of the gram-positive bacteria. This concentration was not much different from the concentration that was safe for mammalian cells (1.50 mg/mL) suggesting that the hydromethanolic extract of Persian shallot may be a safe and strong antibacterial agent.
format Article
author Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
spellingShingle Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
author_facet Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
author_sort Ismail, Salmiah
title Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
title_short Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
title_full Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
title_fullStr Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
title_full_unstemmed Chemical composition and antibacterial and cytotoxic activities of Allium hirtifolium Boiss
title_sort chemical composition and antibacterial and cytotoxic activities of allium hirtifolium boiss
publisher Hindawi Publishing Corporation
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29655/1/Chemical%20composition%20and%20antibacterial%20and%20cytotoxic%20activities%20of%20Allium%20hirtifolium%20Boiss.pdf
http://psasir.upm.edu.my/id/eprint/29655/
http://dx.doi.org/10.1155/2013/696835
_version_ 1643829825420394496
score 13.211869

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