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Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model

Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium,...

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Main Authors: Ahmad Ariffin, Siti Noor Fathilah, Mohamed, Norazlina, Muhammad, Norliza, Mohamed, Isa Naina, Soelaiman, Ima Nirwana, Shuid, Ahmad Nazrun
Format: Article
Language:English
Published: BioMed Central 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf
http://psasir.upm.edu.my/id/eprint/29630/
http://www.biomedcentral.com/1472-6882/13/217
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spelling my.upm.eprints.296302015-09-04T08:12:15Z http://psasir.upm.edu.my/id/eprint/29630/ Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model Ahmad Ariffin, Siti Noor Fathilah Mohamed, Norazlina Muhammad, Norliza Mohamed, Isa Naina Soelaiman, Ima Nirwana Shuid, Ahmad Nazrun Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. The mechanism behind these protective effects is unclear but LPva may have regulated factors that regulate bone remodeling. The aim of this study is to determine the bone-protective mechanism of LPva by measuring the expressions of several factors involved in bone formative and resorptive activities namely Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL), Macrophage-Colony Stimulating Factor (MCSF) and Bone Morphogenetic Protein-2 (BMP-2). BioMed Central 2013-09-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf Ahmad Ariffin, Siti Noor Fathilah and Mohamed, Norazlina and Muhammad, Norliza and Mohamed, Isa Naina and Soelaiman, Ima Nirwana and Shuid, Ahmad Nazrun (2013) Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model. BMC Complementary and Alternative Medicine, 13. art. no. 217. pp. 1-7. ISSN 1472-6882 http://www.biomedcentral.com/1472-6882/13/217 10.1186/1472-6882-13-217
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. The mechanism behind these protective effects is unclear but LPva may have regulated factors that regulate bone remodeling. The aim of this study is to determine the bone-protective mechanism of LPva by measuring the expressions of several factors involved in bone formative and resorptive activities namely Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL), Macrophage-Colony Stimulating Factor (MCSF) and Bone Morphogenetic Protein-2 (BMP-2).
format Article
author Ahmad Ariffin, Siti Noor Fathilah
Mohamed, Norazlina
Muhammad, Norliza
Mohamed, Isa Naina
Soelaiman, Ima Nirwana
Shuid, Ahmad Nazrun
spellingShingle Ahmad Ariffin, Siti Noor Fathilah
Mohamed, Norazlina
Muhammad, Norliza
Mohamed, Isa Naina
Soelaiman, Ima Nirwana
Shuid, Ahmad Nazrun
Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
author_facet Ahmad Ariffin, Siti Noor Fathilah
Mohamed, Norazlina
Muhammad, Norliza
Mohamed, Isa Naina
Soelaiman, Ima Nirwana
Shuid, Ahmad Nazrun
author_sort Ahmad Ariffin, Siti Noor Fathilah
title Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
title_short Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
title_full Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
title_fullStr Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
title_full_unstemmed Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
title_sort labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
publisher BioMed Central
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf
http://psasir.upm.edu.my/id/eprint/29630/
http://www.biomedcentral.com/1472-6882/13/217
_version_ 1643829818230308864
score 13.211869

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