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Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.

As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attenti...

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Main Authors: Abdullah Al-Haj, Nagi Ahmed, Abdullah, Rasedee, Abdelwahab, Siddig Ibrahim, Abdul, Ahmad Bustamam
Format: Article
Language:English
English
Published: Science Publications 2008
Online Access:http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf
http://psasir.upm.edu.my/id/eprint/27056/
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spelling my.upm.eprints.270562015-12-07T03:48:18Z http://psasir.upm.edu.my/id/eprint/27056/ Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. Abdullah Al-Haj, Nagi Ahmed Abdullah, Rasedee Abdelwahab, Siddig Ibrahim Abdul, Ahmad Bustamam As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy. Science Publications 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf Abdullah Al-Haj, Nagi Ahmed and Abdullah, Rasedee and Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam (2008) Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. American Journal of Pharmacology and Toxicology, 3 (3). pp. 219-224. ISSN 1557-4962; ESSN: 1557-4970 10.3844/ajptsp.2008.219.224 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy.
format Article
author Abdullah Al-Haj, Nagi Ahmed
Abdullah, Rasedee
Abdelwahab, Siddig Ibrahim
Abdul, Ahmad Bustamam
spellingShingle Abdullah Al-Haj, Nagi Ahmed
Abdullah, Rasedee
Abdelwahab, Siddig Ibrahim
Abdul, Ahmad Bustamam
Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
author_facet Abdullah Al-Haj, Nagi Ahmed
Abdullah, Rasedee
Abdelwahab, Siddig Ibrahim
Abdul, Ahmad Bustamam
author_sort Abdullah Al-Haj, Nagi Ahmed
title Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
title_short Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
title_full Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
title_fullStr Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
title_full_unstemmed Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
title_sort tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.
publisher Science Publications
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/27056/1/Tamoxifen%20drug%20loading%20solid%20lipid%20nanoparticles%20prepared%20by%20hot%20high%20pressure%20homogenization%20techniques.pdf
http://psasir.upm.edu.my/id/eprint/27056/
_version_ 1643829073726668800
score 13.211869

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