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Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)

Ivermectin has been widely acknowledged to cause neurotoxicity in chelonians even at a dose of 50 µg/kg body weight. Interestingly, another member of the macrocyclic lactone family namely milbemycin, did not induce any observable toxic effects when administered to chelonians at therapeutic doses. H...

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Main Authors: Lee, Vivian Ker Chuon, Goh, Yong Meng, Mohamed Mustapha, Noordin, Choy, Foon Seng
Format: Conference or Workshop Item
Language:English
Published: 2012
Online Access:http://psasir.upm.edu.my/id/eprint/26850/1/PROCEEDING%2063.pdf
http://psasir.upm.edu.my/id/eprint/26850/
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spelling my.upm.eprints.268502016-08-01T09:09:38Z http://psasir.upm.edu.my/id/eprint/26850/ Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans) Lee, Vivian Ker Chuon Goh, Yong Meng Mohamed Mustapha, Noordin Choy, Foon Seng Ivermectin has been widely acknowledged to cause neurotoxicity in chelonians even at a dose of 50 µg/kg body weight. Interestingly, another member of the macrocyclic lactone family namely milbemycin, did not induce any observable toxic effects when administered to chelonians at therapeutic doses. However, injectable milbemycin is currently not available in the market and has to be prepared from technical grade materials. There is a need for injectable endo- and ecto-parasiticides that can be used safely in chelonians, which have a unique anatomy that makes it difficult to administer oral medication. The objective of this study was to determine whether or not doramectin given at twice the usual therapeutic dose (600 µg/kg body weight) will result in toxicity in the red-eared sliders. For this study, the sliders were distributed into 4 groups and doramectin was administered intramuscularly to the sliders according to dose group; low dose group (100 µg/kg body weight, n=4), medium dose group (300 µg/kg body weight, n=4), and a high dose group (600 µg/kg body weight, n=4), while the control group (n=4) was given 0.9% NaCl injections. They were monitored for signs of neurotoxicity, particularly paresis and paralysis for 4 weeks following doramectin administration. Blood samples were taken before treatment and at the conclusion of the study. The red-eared sliders were then humanely euthanised and samples of the liver and brain examined histopathologically. No clinical sign was observed throughout the 4-week study, and the blood results and histopathology did show significant findings. This indicates that doramectin can be used with no obvious adverse effects in red-eared sliders even at a high dose of 600 µg/kg body weight. 2012 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/26850/1/PROCEEDING%2063.pdf Lee, Vivian Ker Chuon and Goh, Yong Meng and Mohamed Mustapha, Noordin and Choy, Foon Seng (2012) Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans). In: 7th Seminar in Veterinary Sciences, 27 Feb.-2 Mar. 2012, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (p. 124).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Ivermectin has been widely acknowledged to cause neurotoxicity in chelonians even at a dose of 50 µg/kg body weight. Interestingly, another member of the macrocyclic lactone family namely milbemycin, did not induce any observable toxic effects when administered to chelonians at therapeutic doses. However, injectable milbemycin is currently not available in the market and has to be prepared from technical grade materials. There is a need for injectable endo- and ecto-parasiticides that can be used safely in chelonians, which have a unique anatomy that makes it difficult to administer oral medication. The objective of this study was to determine whether or not doramectin given at twice the usual therapeutic dose (600 µg/kg body weight) will result in toxicity in the red-eared sliders. For this study, the sliders were distributed into 4 groups and doramectin was administered intramuscularly to the sliders according to dose group; low dose group (100 µg/kg body weight, n=4), medium dose group (300 µg/kg body weight, n=4), and a high dose group (600 µg/kg body weight, n=4), while the control group (n=4) was given 0.9% NaCl injections. They were monitored for signs of neurotoxicity, particularly paresis and paralysis for 4 weeks following doramectin administration. Blood samples were taken before treatment and at the conclusion of the study. The red-eared sliders were then humanely euthanised and samples of the liver and brain examined histopathologically. No clinical sign was observed throughout the 4-week study, and the blood results and histopathology did show significant findings. This indicates that doramectin can be used with no obvious adverse effects in red-eared sliders even at a high dose of 600 µg/kg body weight.
format Conference or Workshop Item
author Lee, Vivian Ker Chuon
Goh, Yong Meng
Mohamed Mustapha, Noordin
Choy, Foon Seng
spellingShingle Lee, Vivian Ker Chuon
Goh, Yong Meng
Mohamed Mustapha, Noordin
Choy, Foon Seng
Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
author_facet Lee, Vivian Ker Chuon
Goh, Yong Meng
Mohamed Mustapha, Noordin
Choy, Foon Seng
author_sort Lee, Vivian Ker Chuon
title Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
title_short Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
title_full Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
title_fullStr Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
title_full_unstemmed Toxicology study on usage of doramectin in red-eared sliders (Trachemys scripta elegans)
title_sort toxicology study on usage of doramectin in red-eared sliders (trachemys scripta elegans)
publishDate 2012
url http://psasir.upm.edu.my/id/eprint/26850/1/PROCEEDING%2063.pdf
http://psasir.upm.edu.my/id/eprint/26850/
_version_ 1643829029280677888
score 13.211869

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