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Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.

Epilepsy is the manifestation of the disease due to overstimulation of the brain. The common signs of this disease are chronic, episodic and recurrent seizures. This problem usually occurs in dogs and cats with the prevalence of the problem estimated about 5.0-5.7 % in dog population and about 0.5...

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Main Authors: Abdul Rahman, Mohd Amir Asyraf, Mohd Noor, Mohd Hezmee, Mustafa, Mohd Zulkifli, Islam, Rafiqul
Format: Conference or Workshop Item
Language:English
English
Published: 2011
Online Access:http://psasir.upm.edu.my/id/eprint/26589/1/Proceedings%207.pdf
http://psasir.upm.edu.my/id/eprint/26589/
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spelling my.upm.eprints.265892014-10-27T08:51:44Z http://psasir.upm.edu.my/id/eprint/26589/ Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model. Abdul Rahman, Mohd Amir Asyraf Mohd Noor, Mohd Hezmee Mustafa, Mohd Zulkifli Islam, Rafiqul Epilepsy is the manifestation of the disease due to overstimulation of the brain. The common signs of this disease are chronic, episodic and recurrent seizures. This problem usually occurs in dogs and cats with the prevalence of the problem estimated about 5.0-5.7 % in dog population and about 0.5 % in the cat population. Today, there is a lot of studies that had been done to search for the new alternative anticonvulsant and antiepilleptic using allopathy or traditional medicine, one of them that had been done was Myristica fragrans Houtt. The volatile oil from the Myristica fragrans Houtt. had been studied and proven to have anticonvulsant effect and one of the constituents suspected to contribute to the anticonvulsant activity was terpineol. This study was done to screen the anti-epileptic effect of terpineol that had been extracted from Myristica fragrans Houtt, essential oil to the kainic acid induced epileptic rat model by determining the effect of terpineol to the behavioural seizure activity and electroencephalogram (EEG) of this model. In this study, 3 adult male SpraqueDawley rats were established with a radiotelemetry system by implanting with electroencephalogram telemetry device and were induced for epilepsy using kainic acid and then treated with the terpineol with doses fo 20 mg/kg and 50 mg/kg. The rats were observed for behavioral seizure activity and electroencephalograms were done qualitatively and quantitatively based on the Racine Scale and EEG semiology. The results of this experiment indicated that terpineol had the antiepileptic properties by inhibiting the behavioral seizure activity and seizure electroencephalogram. The effect of antiepileptic of terpineol also correlated with the doses that were used in this experiment. The possible mechanism of antiepileptic effect of terpineol is by enhancing the gamma-aminobutyric acid (GABA) inhibition mechanism. 2011-01-11 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/26589/1/Proceedings%207.pdf Abdul Rahman, Mohd Amir Asyraf and Mohd Noor, Mohd Hezmee and Mustafa, Mohd Zulkifli and Islam, Rafiqul (2011) Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model. In: 6th Seminar on Veterinary Sciences, 11-14 Jan. 2011, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (pp. 30-36). English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Epilepsy is the manifestation of the disease due to overstimulation of the brain. The common signs of this disease are chronic, episodic and recurrent seizures. This problem usually occurs in dogs and cats with the prevalence of the problem estimated about 5.0-5.7 % in dog population and about 0.5 % in the cat population. Today, there is a lot of studies that had been done to search for the new alternative anticonvulsant and antiepilleptic using allopathy or traditional medicine, one of them that had been done was Myristica fragrans Houtt. The volatile oil from the Myristica fragrans Houtt. had been studied and proven to have anticonvulsant effect and one of the constituents suspected to contribute to the anticonvulsant activity was terpineol. This study was done to screen the anti-epileptic effect of terpineol that had been extracted from Myristica fragrans Houtt, essential oil to the kainic acid induced epileptic rat model by determining the effect of terpineol to the behavioural seizure activity and electroencephalogram (EEG) of this model. In this study, 3 adult male SpraqueDawley rats were established with a radiotelemetry system by implanting with electroencephalogram telemetry device and were induced for epilepsy using kainic acid and then treated with the terpineol with doses fo 20 mg/kg and 50 mg/kg. The rats were observed for behavioral seizure activity and electroencephalograms were done qualitatively and quantitatively based on the Racine Scale and EEG semiology. The results of this experiment indicated that terpineol had the antiepileptic properties by inhibiting the behavioral seizure activity and seizure electroencephalogram. The effect of antiepileptic of terpineol also correlated with the doses that were used in this experiment. The possible mechanism of antiepileptic effect of terpineol is by enhancing the gamma-aminobutyric acid (GABA) inhibition mechanism.
format Conference or Workshop Item
author Abdul Rahman, Mohd Amir Asyraf
Mohd Noor, Mohd Hezmee
Mustafa, Mohd Zulkifli
Islam, Rafiqul
spellingShingle Abdul Rahman, Mohd Amir Asyraf
Mohd Noor, Mohd Hezmee
Mustafa, Mohd Zulkifli
Islam, Rafiqul
Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
author_facet Abdul Rahman, Mohd Amir Asyraf
Mohd Noor, Mohd Hezmee
Mustafa, Mohd Zulkifli
Islam, Rafiqul
author_sort Abdul Rahman, Mohd Amir Asyraf
title Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
title_short Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
title_full Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
title_fullStr Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
title_full_unstemmed Anti-epileptic properties of terpineol extracted from Myristica fragrans Houtt. essential oil in the epileptic rat model.
title_sort anti-epileptic properties of terpineol extracted from myristica fragrans houtt. essential oil in the epileptic rat model.
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/26589/1/Proceedings%207.pdf
http://psasir.upm.edu.my/id/eprint/26589/
_version_ 1643828958116970496
score 13.211869

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