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Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture

Tropical rainforest in Malaysia represents and untapped potential source of antiviral compounds. Bioactive compounds in plant species from the same genus as Kandis Hutan such as xanthones, benzophenones, biflavonoids and lupeol had been studied. Eugeniin is an anti-herpesvirus compound which had a...

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Main Authors: Goh, Sheen Yee, Allaudin, Zeenathul Nazariah, Tan, Seok Shin, Loh, Sandy Hwei San, Ting, Kang Nee, Mohd Lila, Mohd Azmi
Format: Conference or Workshop Item
Language:English
Published: 2011
Online Access:http://psasir.upm.edu.my/id/eprint/26584/1/Proceedings%204.pdf
http://psasir.upm.edu.my/id/eprint/26584/
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spelling my.upm.eprints.265842019-10-30T04:12:25Z http://psasir.upm.edu.my/id/eprint/26584/ Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture Goh, Sheen Yee Allaudin, Zeenathul Nazariah Tan, Seok Shin Loh, Sandy Hwei San Ting, Kang Nee Mohd Lila, Mohd Azmi Tropical rainforest in Malaysia represents and untapped potential source of antiviral compounds. Bioactive compounds in plant species from the same genus as Kandis Hutan such as xanthones, benzophenones, biflavonoids and lupeol had been studied. Eugeniin is an anti-herpesvirus compound which had also been found n Berembang Bukit. This preliminary study was carried out to discover the presence of antiviral properties in Berembang Bukit and Kandis Hutan using different antiviral assays. In this study, MTT cell viability assay was used in addition to microscopic evaluation of pseudorabies virus (PrV)- induced cytopathic effects (CPE) on Vero cells. The cellular toxicity of DMSO was also evaluated. DMSO was less than 10% cytotoxic at concentration of 0.1% to Vero cells and its effect can be negligible. Both plants had demonstrated antiviral properties in thyl acetate and ethanol extracts. From our findings from all three antiviral assays, the ethanol-extracted Kandis Hutan possessed the most promising antiviral properties. Nevertheless, antiviral potential of ethyl acetate and ethanol-extracted Berembang Bukit and ethyl acetate-extracted Kandis Hutan also merit further investigation 2011-01-11 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/26584/1/Proceedings%204.pdf Goh, Sheen Yee and Allaudin, Zeenathul Nazariah and Tan, Seok Shin and Loh, Sandy Hwei San and Ting, Kang Nee and Mohd Lila, Mohd Azmi (2011) Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture. In: 6th Seminar on Veterinary Sciences, 11-14 Jan. 2011, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (pp. 17-21).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Tropical rainforest in Malaysia represents and untapped potential source of antiviral compounds. Bioactive compounds in plant species from the same genus as Kandis Hutan such as xanthones, benzophenones, biflavonoids and lupeol had been studied. Eugeniin is an anti-herpesvirus compound which had also been found n Berembang Bukit. This preliminary study was carried out to discover the presence of antiviral properties in Berembang Bukit and Kandis Hutan using different antiviral assays. In this study, MTT cell viability assay was used in addition to microscopic evaluation of pseudorabies virus (PrV)- induced cytopathic effects (CPE) on Vero cells. The cellular toxicity of DMSO was also evaluated. DMSO was less than 10% cytotoxic at concentration of 0.1% to Vero cells and its effect can be negligible. Both plants had demonstrated antiviral properties in thyl acetate and ethanol extracts. From our findings from all three antiviral assays, the ethanol-extracted Kandis Hutan possessed the most promising antiviral properties. Nevertheless, antiviral potential of ethyl acetate and ethanol-extracted Berembang Bukit and ethyl acetate-extracted Kandis Hutan also merit further investigation
format Conference or Workshop Item
author Goh, Sheen Yee
Allaudin, Zeenathul Nazariah
Tan, Seok Shin
Loh, Sandy Hwei San
Ting, Kang Nee
Mohd Lila, Mohd Azmi
spellingShingle Goh, Sheen Yee
Allaudin, Zeenathul Nazariah
Tan, Seok Shin
Loh, Sandy Hwei San
Ting, Kang Nee
Mohd Lila, Mohd Azmi
Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
author_facet Goh, Sheen Yee
Allaudin, Zeenathul Nazariah
Tan, Seok Shin
Loh, Sandy Hwei San
Ting, Kang Nee
Mohd Lila, Mohd Azmi
author_sort Goh, Sheen Yee
title Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
title_short Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
title_full Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
title_fullStr Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
title_full_unstemmed Antiviral properties of Berembang Bukit and Kandis Hutan against psedorabies virus in animal cell culture
title_sort antiviral properties of berembang bukit and kandis hutan against psedorabies virus in animal cell culture
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/26584/1/Proceedings%204.pdf
http://psasir.upm.edu.my/id/eprint/26584/
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score 13.211869

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