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Immuniregulatory response following fluranthene instillation in embryonated chicken eggs

The immunotoxic effect the air pollutant, floranthene in chicken has never been documented. This study was undertaken to determine the possible immunotoxicity of fluoranthene in embryonated chicken eggs. Fifty 9-day-ole embryonated chicken eggs were used in this study where 40 were each inoculated...

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Main Authors: Abdul Wahid, Firhanis, Mohamed Mustapha, Noordin, Mazlan, Mazlina, Md Isa, Nur Mahiza
Format: Conference or Workshop Item
Language:English
Published: 2011
Online Access:http://psasir.upm.edu.my/id/eprint/26582/1/Immuniregulatory%20response%20following%20fluranthene%20instillation%20in%20embryonated%20chicken%20eggs.pdf
http://psasir.upm.edu.my/id/eprint/26582/
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spelling my.upm.eprints.265822016-11-21T07:48:40Z http://psasir.upm.edu.my/id/eprint/26582/ Immuniregulatory response following fluranthene instillation in embryonated chicken eggs Abdul Wahid, Firhanis Mohamed Mustapha, Noordin Mazlan, Mazlina Md Isa, Nur Mahiza The immunotoxic effect the air pollutant, floranthene in chicken has never been documented. This study was undertaken to determine the possible immunotoxicity of fluoranthene in embryonated chicken eggs. Fifty 9-day-ole embryonated chicken eggs were used in this study where 40 were each inoculated with fluoranthene at the dose of 15 mg/kg via the allantoic route. The remaining 10 eggs were inoculated with phosphate buffered saline (PBS) and acted as controls. All eggs were incubated at 37°C and candled every day for evidence of embryonic survival. Dead embryos (before 21 days old) were necropsied while the allantoic fluid and yolk collected for the determination of ND-HI titers. Chicks that hatched were sacrificed and blood was collected for ND-HI titer determination and lymphoid organs were procured for histopathology. Postmoetem findins fo fluoranthene inoculated embryos were stunted growth, generalized or localized harmorrahages especially at legs and head. Histopathologically, fluoranthene induced lymphoid hyperplasia in the thymus, spleen and bursa. Such change has led to an increase in antibody production compated to the controls. This study has provided evidence that fluoranthene may cross the egg barrier (in ovo) in avian species. 2011-01-11 Conference or Workshop Item NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/26582/1/Immuniregulatory%20response%20following%20fluranthene%20instillation%20in%20embryonated%20chicken%20eggs.pdf Abdul Wahid, Firhanis and Mohamed Mustapha, Noordin and Mazlan, Mazlina and Md Isa, Nur Mahiza (2011) Immuniregulatory response following fluranthene instillation in embryonated chicken eggs. In: 6th Seminar on Veterinary Sciences, 11-14 Jan. 2011, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (pp. 12-16).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The immunotoxic effect the air pollutant, floranthene in chicken has never been documented. This study was undertaken to determine the possible immunotoxicity of fluoranthene in embryonated chicken eggs. Fifty 9-day-ole embryonated chicken eggs were used in this study where 40 were each inoculated with fluoranthene at the dose of 15 mg/kg via the allantoic route. The remaining 10 eggs were inoculated with phosphate buffered saline (PBS) and acted as controls. All eggs were incubated at 37°C and candled every day for evidence of embryonic survival. Dead embryos (before 21 days old) were necropsied while the allantoic fluid and yolk collected for the determination of ND-HI titers. Chicks that hatched were sacrificed and blood was collected for ND-HI titer determination and lymphoid organs were procured for histopathology. Postmoetem findins fo fluoranthene inoculated embryos were stunted growth, generalized or localized harmorrahages especially at legs and head. Histopathologically, fluoranthene induced lymphoid hyperplasia in the thymus, spleen and bursa. Such change has led to an increase in antibody production compated to the controls. This study has provided evidence that fluoranthene may cross the egg barrier (in ovo) in avian species.
format Conference or Workshop Item
author Abdul Wahid, Firhanis
Mohamed Mustapha, Noordin
Mazlan, Mazlina
Md Isa, Nur Mahiza
spellingShingle Abdul Wahid, Firhanis
Mohamed Mustapha, Noordin
Mazlan, Mazlina
Md Isa, Nur Mahiza
Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
author_facet Abdul Wahid, Firhanis
Mohamed Mustapha, Noordin
Mazlan, Mazlina
Md Isa, Nur Mahiza
author_sort Abdul Wahid, Firhanis
title Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
title_short Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
title_full Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
title_fullStr Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
title_full_unstemmed Immuniregulatory response following fluranthene instillation in embryonated chicken eggs
title_sort immuniregulatory response following fluranthene instillation in embryonated chicken eggs
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/26582/1/Immuniregulatory%20response%20following%20fluranthene%20instillation%20in%20embryonated%20chicken%20eggs.pdf
http://psasir.upm.edu.my/id/eprint/26582/
_version_ 1643828956060712960
score 13.211869

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