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Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of F...

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Main Authors: Haw, Choon Yian, Mohamed, Faizal, Chia, Chin Hua, Radiman, Shahidan, Zakaria, Sarani, Huang, Nay Ming, Lim, Hong Ngee
Format: Article
Language:English
Published: Elsevier 2010
Online Access:http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf
http://psasir.upm.edu.my/id/eprint/25173/
http://www.sciencedirect.com/science/article/pii/S0272884210000611
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spelling my.upm.eprints.251732016-03-03T13:38:02Z http://psasir.upm.edu.my/id/eprint/25173/ Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents Haw, Choon Yian Mohamed, Faizal Chia, Chin Hua Radiman, Shahidan Zakaria, Sarani Huang, Nay Ming Lim, Hong Ngee Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of Fe3O4, followed by hydrothermal treatment to produce nano-sized Fe3O4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe3O4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe3O4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe3O4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe3O4 nanoparticles. The superparamagnetic behaviour of the produced Fe3O4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe3O4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging. Elsevier 2010-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf Haw, Choon Yian and Mohamed, Faizal and Chia, Chin Hua and Radiman, Shahidan and Zakaria, Sarani and Huang, Nay Ming and Lim, Hong Ngee (2010) Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. Ceramics International, 36 (4). pp. 1417-1422. ISSN 0272-8842; ESSN: 1873-3956 http://www.sciencedirect.com/science/article/pii/S0272884210000611 10.1016/j.ceramint.2010.02.005
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Magnetite (Fe3O4) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl2·4H2O and FeCl3 with NaOH as reducing agent to initiate the precipitation of Fe3O4, followed by hydrothermal treatment to produce nano-sized Fe3O4. Chitosan (CTS) was coated onto the surface of the as-prepared Fe3O4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe3O4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe3O4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe3O4 nanoparticles. The superparamagnetic behaviour of the produced Fe3O4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe3O4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging.
format Article
author Haw, Choon Yian
Mohamed, Faizal
Chia, Chin Hua
Radiman, Shahidan
Zakaria, Sarani
Huang, Nay Ming
Lim, Hong Ngee
spellingShingle Haw, Choon Yian
Mohamed, Faizal
Chia, Chin Hua
Radiman, Shahidan
Zakaria, Sarani
Huang, Nay Ming
Lim, Hong Ngee
Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
author_facet Haw, Choon Yian
Mohamed, Faizal
Chia, Chin Hua
Radiman, Shahidan
Zakaria, Sarani
Huang, Nay Ming
Lim, Hong Ngee
author_sort Haw, Choon Yian
title Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
title_short Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
title_full Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
title_fullStr Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
title_full_unstemmed Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents
title_sort hydrothermal synthesis of magnetite nanoparticles as mri contrast agents
publisher Elsevier
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/25173/1/Hydrothermal%20synthesis%20of%20magnetite%20nanoparticles%20as%20MRI%20contrast%20agents.pdf
http://psasir.upm.edu.my/id/eprint/25173/
http://www.sciencedirect.com/science/article/pii/S0272884210000611
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score 13.211869

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