Staff View: Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.

Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.

Condensation of SMDTC with 2-furyl-methylketone and 5-methyl-2-furaldehyde gave isomeric Schiff bases, (NS) and (NS'). The metal complexes of these uninegatively charged bidentate Schiff base ligands with cadmium, tin, iron, lead and cobalt have been prepared. The complexes have been characteri...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chew, Kar-Beng, Tarafder, M.T.H., Crouse, Karen Anne, Ali, A.M., Yamin, B.M., Fun, H.-K.
Format:	Article
Language:	English English
Published:	Elsevier 2004
Online Access:	http://psasir.upm.edu.my/id/eprint/24971/1/Synthesis%2C%20characterization%20and%20bio-activity%20of%20metal%20complexes%20.pdf http://psasir.upm.edu.my/id/eprint/24971/ http://www.elsevier.com/
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.upm.eprints.24971
record_format	eprints
spelling	my.upm.eprints.249712015-11-27T02:08:00Z http://psasir.upm.edu.my/id/eprint/24971/ Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex. Chew, Kar-Beng Tarafder, M.T.H. Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.-K. Condensation of SMDTC with 2-furyl-methylketone and 5-methyl-2-furaldehyde gave isomeric Schiff bases, (NS) and (NS'). The metal complexes of these uninegatively charged bidentate Schiff base ligands with cadmium, tin, iron, lead and cobalt have been prepared. The complexes have been characterized by a variety of physico-chemical techniques. X-ray crystallographic analysis shows that the Cd(II) complex, bis[S-methyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II), consists of two molecules with distorted octahedral structure. The Co(II) complexes are paramagnetic with a square-planar stereochemistry. The diamagnetic Sn(II), Fe(III) and Pb(II) complexes also have square-planar structures while the diamagnetic [Cd(NS')2]. 3H2O complex is tetrahedral. The [Cd(NS')2].3H2O, [Sn(N'S)2) and [Co(NS)2] showed clear inhibition of almost all bacteria and fungi tested However, [Cd(NS)2], [Fe(NS)]Cl2, [Pb(NS)2] and [Pb(NS')2] were inactive against all bacteria assayed while [Cd(NS)2], [Fe(NS)]Cl2 and [Pb(NS)2] showed clear inhibition of some fungi. The [Cd(NS)2], [Cd(NS')2].3H2O and [Co(NS)2] were found to be very active against Human cell T-lymphoblastic leukemia (CEM-SS) and cervical cancer cells (HELA) with CD50 values between 1.8 and 3.6 μl cm-3. Elsevier 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24971/1/Synthesis%2C%20characterization%20and%20bio-activity%20of%20metal%20complexes%20.pdf Chew, Kar-Beng and Tarafder, M.T.H. and Crouse, Karen Anne and Ali, A.M. and Yamin, B.M. and Fun, H.-K. (2004) Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex. Polyhedron, 23 (8). pp. 1385-1392. ISSN 0277-5387 http://www.elsevier.com/ English
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English English
description	Condensation of SMDTC with 2-furyl-methylketone and 5-methyl-2-furaldehyde gave isomeric Schiff bases, (NS) and (NS'). The metal complexes of these uninegatively charged bidentate Schiff base ligands with cadmium, tin, iron, lead and cobalt have been prepared. The complexes have been characterized by a variety of physico-chemical techniques. X-ray crystallographic analysis shows that the Cd(II) complex, bis[S-methyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II), consists of two molecules with distorted octahedral structure. The Co(II) complexes are paramagnetic with a square-planar stereochemistry. The diamagnetic Sn(II), Fe(III) and Pb(II) complexes also have square-planar structures while the diamagnetic [Cd(NS')2]. 3H2O complex is tetrahedral. The [Cd(NS')2].3H2O, [Sn(N'S)2) and [Co(NS)2] showed clear inhibition of almost all bacteria and fungi tested However, [Cd(NS)2], [Fe(NS)]Cl2, [Pb(NS)2] and [Pb(NS')2] were inactive against all bacteria assayed while [Cd(NS)2], [Fe(NS)]Cl2 and [Pb(NS)2] showed clear inhibition of some fungi. The [Cd(NS)2], [Cd(NS')2].3H2O and [Co(NS)2] were found to be very active against Human cell T-lymphoblastic leukemia (CEM-SS) and cervical cancer cells (HELA) with CD50 values between 1.8 and 3.6 μl cm-3.
format	Article
author	Chew, Kar-Beng Tarafder, M.T.H. Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.-K.
spellingShingle	Chew, Kar-Beng Tarafder, M.T.H. Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.-K. Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
author_facet	Chew, Kar-Beng Tarafder, M.T.H. Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.-K.
author_sort	Chew, Kar-Beng
title	Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
title_short	Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
title_full	Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
title_fullStr	Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
title_full_unstemmed	Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.
title_sort	synthesis, characterization and bio-activity of metal complexes of bidentate n-s isomeric schiff bases derived from s-methyldithiocarbazate (smdtc) and the x-ray structure of the bis[s-methyl-β-n-(2-furyl-methylketone) dithiocarbazato]cadmium(ii) complex.
publisher	Elsevier
publishDate	2004
url	http://psasir.upm.edu.my/id/eprint/24971/1/Synthesis%2C%20characterization%20and%20bio-activity%20of%20metal%20complexes%20.pdf http://psasir.upm.edu.my/id/eprint/24971/ http://www.elsevier.com/
_version_	1643828519550058496
score	13.211869

Synthesis, characterization and bio-activity of metal complexes of bidentate N-S isomeric Schiff bases derived from S-methyldithiocarbazate (SMDTC) and the X-ray structure of the bis[S-methyl-β-N-(2-furyl-methylketone) dithiocarbazato]cadmium(II) complex.

Similar Items