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Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.

Marmin or 7-(6',7'-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evalu...

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Main Authors: Nugroho, Agung Endro, Anas, Yance, Arsito, Puguh Novi, Wibowo, Joko Tri, Riyanto, Sugeng, Md.Sukari, Mohd. Aspollah
Format: Article
Language:English
English
Published: University of Karachi. Faculty of Pharmacy 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24949/1/Effect%20of%20marmin.pdf
http://psasir.upm.edu.my/id/eprint/24949/
http://www.uok.edu.pk/faculties/pharmacy/
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spelling my.upm.eprints.249492015-12-10T02:05:54Z http://psasir.upm.edu.my/id/eprint/24949/ Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea. Nugroho, Agung Endro Anas, Yance Arsito, Puguh Novi Wibowo, Joko Tri Riyanto, Sugeng Md.Sukari, Mohd. Aspollah Marmin or 7-(6',7'-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of marmin to potentiate the relaxation effect of isoprenaline was also studied. Marmin added in the organ bath at 10 min prior to the agonist inhibited the contraction elicited by histamine and metacholine in a concentration-dependent manner. Moreover, marmin antagonized the histamine-induced contraction in competitive manner. Marmin mildly potentiated the relaxation effect of isoprenaline. In the study, marmin abrogated the contraction of tracheal smooth muscle induced by compound 48/80, an inducer of histamine release. Besides, marmin successfully inhibited CaCl(2)-induced contraction in Ca(2+)-free Krebs solution. Marmin also inhibited two phases of contraction which were consecutively induced by metacholine and CaCl(2) in Ca(2+)-free Krebs solution. Based on the results we concluded that marmin could inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca(2+) release from the intracellular store and the Ca(2+) influx through voltage-dependent Ca(2+) channels. University of Karachi. Faculty of Pharmacy 2011-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24949/1/Effect%20of%20marmin.pdf Nugroho, Agung Endro and Anas, Yance and Arsito, Puguh Novi and Wibowo, Joko Tri and Riyanto, Sugeng and Md.Sukari, Mohd. Aspollah (2011) Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea. Pakistan Journal of Pharmaceutical Sciences, 24 (4). pp. 427-433. ISSN 1011-601X http://www.uok.edu.pk/faculties/pharmacy/ English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Marmin or 7-(6',7'-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of marmin to potentiate the relaxation effect of isoprenaline was also studied. Marmin added in the organ bath at 10 min prior to the agonist inhibited the contraction elicited by histamine and metacholine in a concentration-dependent manner. Moreover, marmin antagonized the histamine-induced contraction in competitive manner. Marmin mildly potentiated the relaxation effect of isoprenaline. In the study, marmin abrogated the contraction of tracheal smooth muscle induced by compound 48/80, an inducer of histamine release. Besides, marmin successfully inhibited CaCl(2)-induced contraction in Ca(2+)-free Krebs solution. Marmin also inhibited two phases of contraction which were consecutively induced by metacholine and CaCl(2) in Ca(2+)-free Krebs solution. Based on the results we concluded that marmin could inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca(2+) release from the intracellular store and the Ca(2+) influx through voltage-dependent Ca(2+) channels.
format Article
author Nugroho, Agung Endro
Anas, Yance
Arsito, Puguh Novi
Wibowo, Joko Tri
Riyanto, Sugeng
Md.Sukari, Mohd. Aspollah
spellingShingle Nugroho, Agung Endro
Anas, Yance
Arsito, Puguh Novi
Wibowo, Joko Tri
Riyanto, Sugeng
Md.Sukari, Mohd. Aspollah
Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
author_facet Nugroho, Agung Endro
Anas, Yance
Arsito, Puguh Novi
Wibowo, Joko Tri
Riyanto, Sugeng
Md.Sukari, Mohd. Aspollah
author_sort Nugroho, Agung Endro
title Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
title_short Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
title_full Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
title_fullStr Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
title_full_unstemmed Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
title_sort effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.
publisher University of Karachi. Faculty of Pharmacy
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24949/1/Effect%20of%20marmin.pdf
http://psasir.upm.edu.my/id/eprint/24949/
http://www.uok.edu.pk/faculties/pharmacy/
_version_ 1643828513019527168
score 13.211869

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