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Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.

The present study aims to determine the role of cytochrome P450 (CYP450) enzyme system in hepatoprotective activity of virgin coconut oils produced by Malaysian Agricultural Research and Development Institute (MARDI). Paracetamol (PCM)-induced hepatotoxic rat was used as a model. Liver injury induce...

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Main Authors:	Zakaria, Zainul Amiruddin, Abdul Kadir, Arifah, Hakim Abdullah, Muhammad Nazrul, Ahmad, Zuraini, Rofiee, Mohd Salleh, Teh, Lay Kek, Salleh, Mohd Zaki, Long, Kamariah
Format:	Article
Language:	English English
Published:	Academic Journals 2011
Online Access:	http://psasir.upm.edu.my/id/eprint/24727/1/Involvement%20of%20CYP450%20system%20in%20hepatoprotective%20activity%20of%20Malaysian%20Agricultural%20Research%20and%20Development%20Institute.pdf http://psasir.upm.edu.my/id/eprint/24727/ http://academicjournals.org
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spelling	my.upm.eprints.247272015-11-18T03:01:22Z http://psasir.upm.edu.my/id/eprint/24727/ Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils. Zakaria, Zainul Amiruddin Abdul Kadir, Arifah Hakim Abdullah, Muhammad Nazrul Ahmad, Zuraini Rofiee, Mohd Salleh Teh, Lay Kek Salleh, Mohd Zaki Long, Kamariah The present study aims to determine the role of cytochrome P450 (CYP450) enzyme system in hepatoprotective activity of virgin coconut oils produced by Malaysian Agricultural Research and Development Institute (MARDI). Paracetamol (PCM)-induced hepatotoxic rat was used as a model. Liver injury induced by 3 g/kg PCM increased the liver weight and liver enzymes (e.g. alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphate (ALP)) and decreased cell viability indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis. Pre-treatment with VCOA or VCOB reversed the significantly (P < 0.05) reversed PCM toxic effect. Groups pre-treated withvirgin coconut oil (VCOs) followed by inhibitor or inducer of CYP450 demonstrated significant (P < 0.0.5) increase in liver weight, liver enzymes levels and decrease in cell viability, which are, however, significantly (P < 0.05) less remarkable as compared to group treated with PCM alone. In conclusion, VCO possessed hepatoprotective effect, which is believed to be mediated via a non-CYP450 system and might be associated partly with the antioxidant potential of the oil. Further studies are warranted to determine the actual mechanisms of hepatoprotection involved. Academic Journals 2011-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24727/1/Involvement%20of%20CYP450%20system%20in%20hepatoprotective%20activity%20of%20Malaysian%20Agricultural%20Research%20and%20Development%20Institute.pdf Zakaria, Zainul Amiruddin and Abdul Kadir, Arifah and Hakim Abdullah, Muhammad Nazrul and Ahmad, Zuraini and Rofiee, Mohd Salleh and Teh, Lay Kek and Salleh, Mohd Zaki and Long, Kamariah (2011) Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils. African Journal of Pharmacy and Pharmacology, 5 (23 ). pp. 2526-2536. ISSN 1996-0816 http://academicjournals.org 10.5897/AJPP11.021 English
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English English
description	The present study aims to determine the role of cytochrome P450 (CYP450) enzyme system in hepatoprotective activity of virgin coconut oils produced by Malaysian Agricultural Research and Development Institute (MARDI). Paracetamol (PCM)-induced hepatotoxic rat was used as a model. Liver injury induced by 3 g/kg PCM increased the liver weight and liver enzymes (e.g. alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphate (ALP)) and decreased cell viability indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis. Pre-treatment with VCOA or VCOB reversed the significantly (P < 0.05) reversed PCM toxic effect. Groups pre-treated withvirgin coconut oil (VCOs) followed by inhibitor or inducer of CYP450 demonstrated significant (P < 0.0.5) increase in liver weight, liver enzymes levels and decrease in cell viability, which are, however, significantly (P < 0.05) less remarkable as compared to group treated with PCM alone. In conclusion, VCO possessed hepatoprotective effect, which is believed to be mediated via a non-CYP450 system and might be associated partly with the antioxidant potential of the oil. Further studies are warranted to determine the actual mechanisms of hepatoprotection involved.
format	Article
author	Zakaria, Zainul Amiruddin Abdul Kadir, Arifah Hakim Abdullah, Muhammad Nazrul Ahmad, Zuraini Rofiee, Mohd Salleh Teh, Lay Kek Salleh, Mohd Zaki Long, Kamariah
spellingShingle	Zakaria, Zainul Amiruddin Abdul Kadir, Arifah Hakim Abdullah, Muhammad Nazrul Ahmad, Zuraini Rofiee, Mohd Salleh Teh, Lay Kek Salleh, Mohd Zaki Long, Kamariah Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
author_facet	Zakaria, Zainul Amiruddin Abdul Kadir, Arifah Hakim Abdullah, Muhammad Nazrul Ahmad, Zuraini Rofiee, Mohd Salleh Teh, Lay Kek Salleh, Mohd Zaki Long, Kamariah
author_sort	Zakaria, Zainul Amiruddin
title	Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
title_short	Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
title_full	Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
title_fullStr	Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
title_full_unstemmed	Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
title_sort	involvement of cyp450 system in hepatoprotective activity of malaysian agricultural research and development institute (mardi)-produced virgin coconut oils.
publisher	Academic Journals
publishDate	2011
url	http://psasir.upm.edu.my/id/eprint/24727/1/Involvement%20of%20CYP450%20system%20in%20hepatoprotective%20activity%20of%20Malaysian%20Agricultural%20Research%20and%20Development%20Institute.pdf http://psasir.upm.edu.my/id/eprint/24727/ http://academicjournals.org
_version_	1643828447730991104
score	13.211869

Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.

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