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Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?

The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells c...

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Main Authors: Eshkoor, Sima Ataollahi, Ismail , Patimah, Abdul Rahman, Sabariah, Moin, Saidi
Format: Article
Language:English
English
Published: Institute for Medical Research and Occupational Health, Zagreb 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf
http://psasir.upm.edu.my/id/eprint/24706/
http://www.imi.hr/
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spelling my.upm.eprints.247062015-09-09T06:55:13Z http://psasir.upm.edu.my/id/eprint/24706/ Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? Eshkoor, Sima Ataollahi Ismail , Patimah Abdul Rahman, Sabariah Moin, Saidi The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed (control) subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism (RFLP), MN test, comet assay, and real-time PCR. The results confirmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the influence of GSTP1 gene polymorphism on DNA damage. However, further studies on both occupationally exposed and control populations are needed to understand the relationship between GSTP1 polymorphism and genome damage. Institute for Medical Research and Occupational Health, Zagreb 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf Eshkoor, Sima Ataollahi and Ismail , Patimah and Abdul Rahman, Sabariah and Moin, Saidi (2011) Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? Arhiv za Higijenu Rada i Toksikologiju , 62 (4). pp. 291-298. ISSN 0004-1254 http://www.imi.hr/ 10.2478/10004-1254-62-2011-2088 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed (control) subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism (RFLP), MN test, comet assay, and real-time PCR. The results confirmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the influence of GSTP1 gene polymorphism on DNA damage. However, further studies on both occupationally exposed and control populations are needed to understand the relationship between GSTP1 polymorphism and genome damage.
format Article
author Eshkoor, Sima Ataollahi
Ismail , Patimah
Abdul Rahman, Sabariah
Moin, Saidi
spellingShingle Eshkoor, Sima Ataollahi
Ismail , Patimah
Abdul Rahman, Sabariah
Moin, Saidi
Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
author_facet Eshkoor, Sima Ataollahi
Ismail , Patimah
Abdul Rahman, Sabariah
Moin, Saidi
author_sort Eshkoor, Sima Ataollahi
title Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
title_short Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
title_full Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
title_fullStr Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
title_full_unstemmed Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
title_sort does gstp1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
publisher Institute for Medical Research and Occupational Health, Zagreb
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf
http://psasir.upm.edu.my/id/eprint/24706/
http://www.imi.hr/
_version_ 1643828441445826560
score 13.211869

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