Cover Image

Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract

Ardisia crispa (Family: Myrsinaceae) has been used as a traditional medicine for various ailments. Previous studies showed that Ardisia crispa possesses antimetastatic and anti-inflammatory properties. Nevertheless, research done on the plant is still limited. Therefore, the present study was design...

Full description

Saved in:
Bibliographic Details
Main Authors: Abd Hamid @ Abdul Razak, Roslida, Othman, Fezah, Yeong, Looi Ting
Format: Article
Language:English
Published: Asian Pacific Organization for Cancer Prevention 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24701/1/24701.pdf
http://psasir.upm.edu.my/id/eprint/24701/
http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:21627361&key=2011.12.3.665
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.24701
record_format eprints
spelling my.upm.eprints.247012016-10-28T09:17:11Z http://psasir.upm.edu.my/id/eprint/24701/ Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract Abd Hamid @ Abdul Razak, Roslida Othman, Fezah Yeong, Looi Ting Ardisia crispa (Family: Myrsinaceae) has been used as a traditional medicine for various ailments. Previous studies showed that Ardisia crispa possesses antimetastatic and anti-inflammatory properties. Nevertheless, research done on the plant is still limited. Therefore, the present study was designed to evaluate the suppression effect of Ardisia crispa root hexane (ACRH) extract on 7, 12-dimethylbenz (α) anthracene (DMBA)-induced mice skin tumor promotion in ICR mice with topical application twice weekly for 10 weeks. Results showed significant difference between treatment groups (mice treated with 30 mg/kg, 100 mg/kg and 300 mg/kg of ACRH extract; denoted as group I, II and III respectively) for tumor incidence and tumor burden (P<0.05). Significant reduction in tumor incidence (20%), tumor burden (1.5 ± 0.50), tumor volume (2.49 ± 1.70) and delayed latency period of tumor formation was observed in group I (30 mg/kg) in comparison to carcinogen control. This study indicates that ACRH extract could be a promising skin tumor promotion suppressing agent at a lower dosage (30 mg/kg). Further studies are required to elucidate the underlying mechanism(s) leading to this effect. Asian Pacific Organization for Cancer Prevention 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24701/1/24701.pdf Abd Hamid @ Abdul Razak, Roslida and Othman, Fezah and Yeong, Looi Ting (2011) Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract. Asian Pacific Journal of Cancer Prevention, 12 (3). pp. 665-669. ISSN 1513-7368; ESSN: 2476-762X http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:21627361&key=2011.12.3.665
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Ardisia crispa (Family: Myrsinaceae) has been used as a traditional medicine for various ailments. Previous studies showed that Ardisia crispa possesses antimetastatic and anti-inflammatory properties. Nevertheless, research done on the plant is still limited. Therefore, the present study was designed to evaluate the suppression effect of Ardisia crispa root hexane (ACRH) extract on 7, 12-dimethylbenz (α) anthracene (DMBA)-induced mice skin tumor promotion in ICR mice with topical application twice weekly for 10 weeks. Results showed significant difference between treatment groups (mice treated with 30 mg/kg, 100 mg/kg and 300 mg/kg of ACRH extract; denoted as group I, II and III respectively) for tumor incidence and tumor burden (P<0.05). Significant reduction in tumor incidence (20%), tumor burden (1.5 ± 0.50), tumor volume (2.49 ± 1.70) and delayed latency period of tumor formation was observed in group I (30 mg/kg) in comparison to carcinogen control. This study indicates that ACRH extract could be a promising skin tumor promotion suppressing agent at a lower dosage (30 mg/kg). Further studies are required to elucidate the underlying mechanism(s) leading to this effect.
format Article
author Abd Hamid @ Abdul Razak, Roslida
Othman, Fezah
Yeong, Looi Ting
spellingShingle Abd Hamid @ Abdul Razak, Roslida
Othman, Fezah
Yeong, Looi Ting
Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
author_facet Abd Hamid @ Abdul Razak, Roslida
Othman, Fezah
Yeong, Looi Ting
author_sort Abd Hamid @ Abdul Razak, Roslida
title Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
title_short Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
title_full Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
title_fullStr Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
title_full_unstemmed Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia crispa root hexane extract
title_sort suppression of dmba/croton oil-induced mouse skin tumor promotion by ardisia crispa root hexane extract
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24701/1/24701.pdf
http://psasir.upm.edu.my/id/eprint/24701/
http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:21627361&key=2011.12.3.665
_version_ 1643828439959994368
score 13.211869

Similar Items