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Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.

Different parts of four edible medicinal plants (Casearia capitellata, Baccaurea motleyana, Phyllanthus pulcher and Strobilanthus crispus), indigenous to Malaysia, were extracted in different solvents, sequentially. The obtained 28 extracts were evaluated for their in vitro anticancer properties, us...

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Main Authors:	Ismail, Maznah, Bagalkotkar, Gururaj, Iqbal, Shahid, Adamu, HadizaAltine
Format:	Article
Language:	English English
Published:	MDPI 2012
Online Access:	http://psasir.upm.edu.my/id/eprint/24617/1/Anticancer%20properties%20and%20phenolic%20contents%20of%20sequentially%20prepared%20extracts%20from%20different%20parts%20of%20selected%20medicinal%20plants%20indigenous%20to%20Malaysia.pdf http://psasir.upm.edu.my/id/eprint/24617/ http://www.mdpi.com/
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spelling	my.upm.eprints.246172015-09-22T04:49:38Z http://psasir.upm.edu.my/id/eprint/24617/ Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia. Ismail, Maznah Bagalkotkar, Gururaj Iqbal, Shahid Adamu, HadizaAltine Different parts of four edible medicinal plants (Casearia capitellata, Baccaurea motleyana, Phyllanthus pulcher and Strobilanthus crispus), indigenous to Malaysia, were extracted in different solvents, sequentially. The obtained 28 extracts were evaluated for their in vitro anticancer properties, using the MTS assay, on four human cancer cell lines: colon (HT-29), breast (MCF-7), prostate (DU-145) and lung (H460) cancers. The best anticancer activity was observed for the ethyl acetate (EA) extract of Casearia capitellata leaves on MCF-7 cell lines with IC50 2.0 μg/mL and its methanolic (MeOH) extract showed an outstanding activity against lung cancer cell lines. Dichloromethane (DCM) extract of Phyllanthus pulcher aerial parts showed the highest anticancer activity against DU-145 cell lines, while significant activity was exhibited by DCM extract of Phyllanthus pulcher roots on colon cancer cell lines with IC50 value of 8.1 μg/mL. Total phenolic content (TPC) ranged over 1-40 mg gallic acid equivalents (GAE)/g. For all the samples, highest yields of phenolics were obtained for MeOH extracts. Among all the extracts analyzed, the MeOH extracts of Strobilanthus crispus leaves exhibited the highest TPC than other samples (p < 0.05). This study shows that the nature of phenol determines its anticaner activity and not the number of phenols present. MDPI 2012 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24617/1/Anticancer%20properties%20and%20phenolic%20contents%20of%20sequentially%20prepared%20extracts%20from%20different%20parts%20of%20selected%20medicinal%20plants%20indigenous%20to%20Malaysia.pdf Ismail, Maznah and Bagalkotkar, Gururaj and Iqbal, Shahid and Adamu, HadizaAltine (2012) Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia. Molecules, 17 (5). pp. 5745-5756. ISSN 1420-3049; ESSN:1420-3049 http://www.mdpi.com/ 10.3390/molecules17055745 English
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English English
description	Different parts of four edible medicinal plants (Casearia capitellata, Baccaurea motleyana, Phyllanthus pulcher and Strobilanthus crispus), indigenous to Malaysia, were extracted in different solvents, sequentially. The obtained 28 extracts were evaluated for their in vitro anticancer properties, using the MTS assay, on four human cancer cell lines: colon (HT-29), breast (MCF-7), prostate (DU-145) and lung (H460) cancers. The best anticancer activity was observed for the ethyl acetate (EA) extract of Casearia capitellata leaves on MCF-7 cell lines with IC50 2.0 μg/mL and its methanolic (MeOH) extract showed an outstanding activity against lung cancer cell lines. Dichloromethane (DCM) extract of Phyllanthus pulcher aerial parts showed the highest anticancer activity against DU-145 cell lines, while significant activity was exhibited by DCM extract of Phyllanthus pulcher roots on colon cancer cell lines with IC50 value of 8.1 μg/mL. Total phenolic content (TPC) ranged over 1-40 mg gallic acid equivalents (GAE)/g. For all the samples, highest yields of phenolics were obtained for MeOH extracts. Among all the extracts analyzed, the MeOH extracts of Strobilanthus crispus leaves exhibited the highest TPC than other samples (p < 0.05). This study shows that the nature of phenol determines its anticaner activity and not the number of phenols present.
format	Article
author	Ismail, Maznah Bagalkotkar, Gururaj Iqbal, Shahid Adamu, HadizaAltine
spellingShingle	Ismail, Maznah Bagalkotkar, Gururaj Iqbal, Shahid Adamu, HadizaAltine Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
author_facet	Ismail, Maznah Bagalkotkar, Gururaj Iqbal, Shahid Adamu, HadizaAltine
author_sort	Ismail, Maznah
title	Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
title_short	Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
title_full	Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
title_fullStr	Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
title_full_unstemmed	Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.
title_sort	anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to malaysia.
publisher	MDPI
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/24617/1/Anticancer%20properties%20and%20phenolic%20contents%20of%20sequentially%20prepared%20extracts%20from%20different%20parts%20of%20selected%20medicinal%20plants%20indigenous%20to%20Malaysia.pdf http://psasir.upm.edu.my/id/eprint/24617/ http://www.mdpi.com/
_version_	1643828415530270720
score	13.211869

Anticancer properties and phenolic contents of sequentially prepared extracts from different parts of selected medicinal plants indigenous to Malaysia.

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