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Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.

In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women’s health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifestyle-...

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Main Authors: Parhizkar, Saadat, Abd Latiff, Latiffah, Abdul Rahman, Sabariah, Dollah, Mohammad Aziz
Format: Article
Language:English
English
Published: Academic Journals 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24569/1/Preventive%20effect%20of%20Nigella%20sativa%20on%20metabolic%20syndrome%20in%20menopause%20induced%20rats.pdf
http://psasir.upm.edu.my/id/eprint/24569/
http://www.academicjournals.org/journal/JMPR/
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spelling my.upm.eprints.245692015-10-28T07:10:59Z http://psasir.upm.edu.my/id/eprint/24569/ Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats. Parhizkar, Saadat Abd Latiff, Latiffah Abdul Rahman, Sabariah Dollah, Mohammad Aziz In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women’s health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifestyle-related diseases such as hypertension, type II diabetes mellitus, arteriosclerosis and metabolic syndrome, making it essential to prevent weight gain in women. This study was conducted using an ovariectomized rat model to determine the metabolic impact of Nigella sativa in experimental menopause induced rats.Forty ovariectomized Sprague Dawley rats, weighting 250 to 350 g were used in the study and randomly allotted into one of five experimental groups. Animals were given either different doses of N. sativa (300, 600, 1200 mg/kg/day) as treatment groups or distilled water (1 ml) and conjugated equine estrogen (CEE) (200 μg/kg/day) by intra-gastric gavage as negative and positive control group respectively for 21 days. Food and water intake were measured daily and body weight and biochemical parameters were measured at baseline, 11th day and at the end of experiment. The treatment groups showed significant (P < 0.05) improvement with reference to daily body weight gain, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and blood glucose (P < 0.05). There were no significant differences between groups in serum triglyceride concentration. These results suggested that treatment with N. sativa exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose as well as hormonal level which is believed to play an important role in the pathogenesis of metabolic syndrome during menopause. Academic Journals 2011-04-18 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24569/1/Preventive%20effect%20of%20Nigella%20sativa%20on%20metabolic%20syndrome%20in%20menopause%20induced%20rats.pdf Parhizkar, Saadat and Abd Latiff, Latiffah and Abdul Rahman, Sabariah and Dollah, Mohammad Aziz (2011) Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats. Journal of Medicinal Plants Research, 5 (8). pp. 1478-1484. ISSN 1996-0875 http://www.academicjournals.org/journal/JMPR/ English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women’s health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifestyle-related diseases such as hypertension, type II diabetes mellitus, arteriosclerosis and metabolic syndrome, making it essential to prevent weight gain in women. This study was conducted using an ovariectomized rat model to determine the metabolic impact of Nigella sativa in experimental menopause induced rats.Forty ovariectomized Sprague Dawley rats, weighting 250 to 350 g were used in the study and randomly allotted into one of five experimental groups. Animals were given either different doses of N. sativa (300, 600, 1200 mg/kg/day) as treatment groups or distilled water (1 ml) and conjugated equine estrogen (CEE) (200 μg/kg/day) by intra-gastric gavage as negative and positive control group respectively for 21 days. Food and water intake were measured daily and body weight and biochemical parameters were measured at baseline, 11th day and at the end of experiment. The treatment groups showed significant (P < 0.05) improvement with reference to daily body weight gain, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and blood glucose (P < 0.05). There were no significant differences between groups in serum triglyceride concentration. These results suggested that treatment with N. sativa exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose as well as hormonal level which is believed to play an important role in the pathogenesis of metabolic syndrome during menopause.
format Article
author Parhizkar, Saadat
Abd Latiff, Latiffah
Abdul Rahman, Sabariah
Dollah, Mohammad Aziz
spellingShingle Parhizkar, Saadat
Abd Latiff, Latiffah
Abdul Rahman, Sabariah
Dollah, Mohammad Aziz
Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
author_facet Parhizkar, Saadat
Abd Latiff, Latiffah
Abdul Rahman, Sabariah
Dollah, Mohammad Aziz
author_sort Parhizkar, Saadat
title Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
title_short Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
title_full Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
title_fullStr Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
title_full_unstemmed Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats.
title_sort preventive effect of nigella sativa on metabolic syndrome in menopause induced rats.
publisher Academic Journals
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24569/1/Preventive%20effect%20of%20Nigella%20sativa%20on%20metabolic%20syndrome%20in%20menopause%20induced%20rats.pdf
http://psasir.upm.edu.my/id/eprint/24569/
http://www.academicjournals.org/journal/JMPR/
_version_ 1643828399149416448
score 13.211869

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