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Aggressive variant large granular lymphocytic leukaemia: a case report

Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified...

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Main Authors: Md Noor, Sabariah, Seman, Zainina, Idris, Faridah, Leong, Chooi Fun
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf
http://psasir.upm.edu.my/id/eprint/24511/
http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2011V07N1_OP08.pdf
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spelling my.upm.eprints.245112015-09-08T03:51:53Z http://psasir.upm.edu.my/id/eprint/24511/ Aggressive variant large granular lymphocytic leukaemia: a case report Md Noor, Sabariah Seman, Zainina Idris, Faridah Leong, Chooi Fun Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt all standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2011-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf Md Noor, Sabariah and Seman, Zainina and Idris, Faridah and Leong, Chooi Fun (2011) Aggressive variant large granular lymphocytic leukaemia: a case report. Malaysian Journal of Medicine and Health Sciences, 7 (1). pp. 57-60. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2011V07N1_OP08.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt all standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management.
format Article
author Md Noor, Sabariah
Seman, Zainina
Idris, Faridah
Leong, Chooi Fun
spellingShingle Md Noor, Sabariah
Seman, Zainina
Idris, Faridah
Leong, Chooi Fun
Aggressive variant large granular lymphocytic leukaemia: a case report
author_facet Md Noor, Sabariah
Seman, Zainina
Idris, Faridah
Leong, Chooi Fun
author_sort Md Noor, Sabariah
title Aggressive variant large granular lymphocytic leukaemia: a case report
title_short Aggressive variant large granular lymphocytic leukaemia: a case report
title_full Aggressive variant large granular lymphocytic leukaemia: a case report
title_fullStr Aggressive variant large granular lymphocytic leukaemia: a case report
title_full_unstemmed Aggressive variant large granular lymphocytic leukaemia: a case report
title_sort aggressive variant large granular lymphocytic leukaemia: a case report
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf
http://psasir.upm.edu.my/id/eprint/24511/
http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2011V07N1_OP08.pdf
_version_ 1643828382247419904
score 13.211869

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