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Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.

Kenaf (Hibiscus cannabinus) from the family of Malvaceae is a valuable fibre plant native to India and Africa. Kenaf is composed of various active components including tannins, saponins, polyphenolics, alkaloids, essential oils and steroids. It has been used to treat bruises, bilious conditions, fev...

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Main Authors: Saiful Yazan , Latifah, Foo, Jhi Bhiau, Abd Ghafar, Siti Aisyah, Chan, Kim Wei, Md. Tahir, Paridah, Ismail, Maznah
Format: Article
Language:English
English
Published: Elsevier 2011
Online Access:http://psasir.upm.edu.my/id/eprint/23926/1/Effect%20of%20kenaf%20seed%20oil%20from%20different%20ways%20of%20extraction%20towards%20ovarian%20cancer%20cells.pdf
http://psasir.upm.edu.my/id/eprint/23926/
http://www.elsevier.com
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spelling my.upm.eprints.239262016-02-18T02:26:14Z http://psasir.upm.edu.my/id/eprint/23926/ Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells. Saiful Yazan , Latifah Foo, Jhi Bhiau Abd Ghafar, Siti Aisyah Chan, Kim Wei Md. Tahir, Paridah Ismail, Maznah Kenaf (Hibiscus cannabinus) from the family of Malvaceae is a valuable fibre plant native to India and Africa. Kenaf is composed of various active components including tannins, saponins, polyphenolics, alkaloids, essential oils and steroids. It has been used to treat bruises, bilious conditions, fever and puerperium. Nevertheless, the anti-cancer properties of kenaf seed oil have not yet been investigated. In this study, kenaf seed oils obtained by Sonication, Soxhlet and supercritical carbon dioxide fluid extraction (SFE) with 9 different combinations of pressure (bars) and temperature (°C) (200/40, 200/60, 200/80, 400/40, 400/60, 400/80, 600/40, 600/60 and 600/80) were investigated for the cytotoxicities. All the oils were cytotoxic towards ovarian cancer (CaOV3) and colon cancer (HT29) cell lines in a dose dependent manner as detected by using the MTT assay and trypan blue dye exclusion method. Oil from Sonication was the most cytotoxic towards CaOV3 cell line. Treated cells exhibited characteristics of apoptosis such as chromatin condensation and nuclear fragmentation. In conclusion, kenaf seed oils from the three extractions were cytotoxic towards CaOV3 cell line in a dose-dependent manner possibly via the induction of apoptosis. In considering the safety of the product, SFE technology is a better alternative extraction method that is suitable in kenaf seed oil extraction. Elsevier 2011-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23926/1/Effect%20of%20kenaf%20seed%20oil%20from%20different%20ways%20of%20extraction%20towards%20ovarian%20cancer%20cells.pdf Saiful Yazan , Latifah and Foo, Jhi Bhiau and Abd Ghafar, Siti Aisyah and Chan, Kim Wei and Md. Tahir, Paridah and Ismail, Maznah (2011) Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells. Food and Bioproducts Processing, 89 (4). pp. 328-332. ISSN 0960-3085 http://www.elsevier.com 10.1016/j.fbp.2010.10.007 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Kenaf (Hibiscus cannabinus) from the family of Malvaceae is a valuable fibre plant native to India and Africa. Kenaf is composed of various active components including tannins, saponins, polyphenolics, alkaloids, essential oils and steroids. It has been used to treat bruises, bilious conditions, fever and puerperium. Nevertheless, the anti-cancer properties of kenaf seed oil have not yet been investigated. In this study, kenaf seed oils obtained by Sonication, Soxhlet and supercritical carbon dioxide fluid extraction (SFE) with 9 different combinations of pressure (bars) and temperature (°C) (200/40, 200/60, 200/80, 400/40, 400/60, 400/80, 600/40, 600/60 and 600/80) were investigated for the cytotoxicities. All the oils were cytotoxic towards ovarian cancer (CaOV3) and colon cancer (HT29) cell lines in a dose dependent manner as detected by using the MTT assay and trypan blue dye exclusion method. Oil from Sonication was the most cytotoxic towards CaOV3 cell line. Treated cells exhibited characteristics of apoptosis such as chromatin condensation and nuclear fragmentation. In conclusion, kenaf seed oils from the three extractions were cytotoxic towards CaOV3 cell line in a dose-dependent manner possibly via the induction of apoptosis. In considering the safety of the product, SFE technology is a better alternative extraction method that is suitable in kenaf seed oil extraction.
format Article
author Saiful Yazan , Latifah
Foo, Jhi Bhiau
Abd Ghafar, Siti Aisyah
Chan, Kim Wei
Md. Tahir, Paridah
Ismail, Maznah
spellingShingle Saiful Yazan , Latifah
Foo, Jhi Bhiau
Abd Ghafar, Siti Aisyah
Chan, Kim Wei
Md. Tahir, Paridah
Ismail, Maznah
Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
author_facet Saiful Yazan , Latifah
Foo, Jhi Bhiau
Abd Ghafar, Siti Aisyah
Chan, Kim Wei
Md. Tahir, Paridah
Ismail, Maznah
author_sort Saiful Yazan , Latifah
title Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
title_short Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
title_full Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
title_fullStr Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
title_full_unstemmed Effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
title_sort effect of kenaf seed oil from different ways of extraction towards ovarian cancer cells.
publisher Elsevier
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/23926/1/Effect%20of%20kenaf%20seed%20oil%20from%20different%20ways%20of%20extraction%20towards%20ovarian%20cancer%20cells.pdf
http://psasir.upm.edu.my/id/eprint/23926/
http://www.elsevier.com
_version_ 1643828207660564480
score 13.211869

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