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Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.

Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections....

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Main Authors: Mohd Ikhsan, Natrah Fatin, Kenmegne, Mireille Mardel, Wiyoto, Wiyoto, Sorgeloos, Patrick, Bossier, Peter, Defoirdt, Tom
Format: Article
Language:English
English
Published: Elsevier 2011
Online Access:http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf
http://psasir.upm.edu.my/id/eprint/23849/
http://www.elsevier.com/
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spelling my.upm.eprints.238492015-10-16T06:57:13Z http://psasir.upm.edu.my/id/eprint/23849/ Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Mohd Ikhsan, Natrah Fatin Kenmegne, Mireille Mardel Wiyoto, Wiyoto Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains. Elsevier 2011-07-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf Mohd Ikhsan, Natrah Fatin and Kenmegne, Mireille Mardel and Wiyoto, Wiyoto and Sorgeloos, Patrick and Bossier, Peter and Defoirdt, Tom (2011) Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Aquaculture, 317 (1). pp. 53-57. ISSN 0044-8486 http://www.elsevier.com/ English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains.
format Article
author Mohd Ikhsan, Natrah Fatin
Kenmegne, Mireille Mardel
Wiyoto, Wiyoto
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
spellingShingle Mohd Ikhsan, Natrah Fatin
Kenmegne, Mireille Mardel
Wiyoto, Wiyoto
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
author_facet Mohd Ikhsan, Natrah Fatin
Kenmegne, Mireille Mardel
Wiyoto, Wiyoto
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
author_sort Mohd Ikhsan, Natrah Fatin
title Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
title_short Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
title_full Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
title_fullStr Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
title_full_unstemmed Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
title_sort effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
publisher Elsevier
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf
http://psasir.upm.edu.my/id/eprint/23849/
http://www.elsevier.com/
_version_ 1643828184627544064
score 13.211869

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