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Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals

Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of...

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Main Authors:	Sulaiman, Mohd Roslan, Mohd Padzil, Azyyati, Shaari, Khozirah, Khalid, Syamimi, Shaik Mossadeq, Wan Mastura, Tengku Mohamad, Azam Shah, Ahmad, Syahida, Omar Farouk, Ahmad Akira, Israf Ali, Daud Ahmad, Lajis, Md. Nordin
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2010
Online Access:	http://psasir.upm.edu.my/id/eprint/22242/1/Antinociceptive%20Activity%20of%20Melicope%20ptelefolia%20Ethanolic%20Extract%20in%20Experimental%20Animals.pdf http://psasir.upm.edu.my/id/eprint/22242/
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spelling	my.upm.eprints.222422016-02-19T02:22:41Z http://psasir.upm.edu.my/id/eprint/22242/ Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Tengku Mohamad, Azam Shah Ahmad, Syahida Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Lajis, Md. Nordin Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals. Hindawi Publishing Corporation 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22242/1/Antinociceptive%20Activity%20of%20Melicope%20ptelefolia%20Ethanolic%20Extract%20in%20Experimental%20Animals.pdf Sulaiman, Mohd Roslan and Mohd Padzil, Azyyati and Shaari, Khozirah and Khalid, Syamimi and Shaik Mossadeq, Wan Mastura and Tengku Mohamad, Azam Shah and Ahmad, Syahida and Omar Farouk, Ahmad Akira and Israf Ali, Daud Ahmad and Lajis, Md. Nordin (2010) Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals. Journal of Biomedicine and Biotechnology, 2010. art. no. 937642. pp. 1-6. ISSN 1110-7243; ESSN: 1110-7251 10.1155/2010/937642
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches. The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests. Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively. It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test. In addition, the antinociception produced by MPEE was not blocked by naloxone. Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg. These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals.
format	Article
author	Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Tengku Mohamad, Azam Shah Ahmad, Syahida Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Lajis, Md. Nordin
spellingShingle	Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Tengku Mohamad, Azam Shah Ahmad, Syahida Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Lajis, Md. Nordin Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
author_facet	Sulaiman, Mohd Roslan Mohd Padzil, Azyyati Shaari, Khozirah Khalid, Syamimi Shaik Mossadeq, Wan Mastura Tengku Mohamad, Azam Shah Ahmad, Syahida Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Lajis, Md. Nordin
author_sort	Sulaiman, Mohd Roslan
title	Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
title_short	Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
title_full	Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
title_fullStr	Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
title_full_unstemmed	Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
title_sort	antinociceptive activity of melicope ptefolia ethanolic extract in experimental animals
publisher	Hindawi Publishing Corporation
publishDate	2010
url	http://psasir.upm.edu.my/id/eprint/22242/1/Antinociceptive%20Activity%20of%20Melicope%20ptelefolia%20Ethanolic%20Extract%20in%20Experimental%20Animals.pdf http://psasir.upm.edu.my/id/eprint/22242/
_version_	1643827770658127872
score	13.211869

Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals

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