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Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia

Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. T...

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Main Authors: Hamat, Rukman Awang, Embran, Nor Amalina, Sekawi, Zamberi, Osman, Malina, Hanafiah, Alfizah, Abdul Manaf, Mohd Rizal, Adnan, Aminuddin, Mohamed, Ramelah
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2013
Online Access:http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf
http://psasir.upm.edu.my/id/eprint/22165/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2036%20(4)%20Nov.%202013/01%20Page%20289-298.pdf
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spelling my.upm.eprints.221652015-11-24T08:53:48Z http://psasir.upm.edu.my/id/eprint/22165/ Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia Hamat, Rukman Awang Embran, Nor Amalina Sekawi, Zamberi Osman, Malina Hanafiah, Alfizah Abdul Manaf, Mohd Rizal Adnan, Aminuddin Mohamed, Ramelah Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. The Indians had the highest prevalence of H. pylori infection among other ethnic groups (Malays= 8.6 %, Chinese= 24.3 %, Indians= 33.9%). cagM and cagT were the most predominant genes found (63.4% for each), followed by cagA (62.2 %), cagE (48.2%), cag6-7 (46.3%), cag10 (42.1%), cag13 (4.9%) and IS605 (3.7%). No significant association was found between H. pylori infection and H. pylori genes with ethnic groups or clinical outcomes. Indians who had a combination of cagA/ E/M genes of H. pylori were likely to be associated with 21-time of having non-ulcer dyspepsia (NUD) than peptic ulcer disease (PUD). Therefore, these genes may serve as useful markers in predicting the clinical presentation of a H. pylori infection among Indians in our studied population. Hence, this preliminary data might explain why Indians have a low prevalence of gastric cancer and peptic ulcer disease despite having persistently high prevalence of H. pylori infection for many decades (“Indian enigma�) in Malaysian patients. Universiti Putra Malaysia Press 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf Hamat, Rukman Awang and Embran, Nor Amalina and Sekawi, Zamberi and Osman, Malina and Hanafiah, Alfizah and Abdul Manaf, Mohd Rizal and Adnan, Aminuddin and Mohamed, Ramelah (2013) Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia. Pertanika Journal of Tropical Agricultural Science, 36 (4). pp. 289-298. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2036%20(4)%20Nov.%202013/01%20Page%20289-298.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. The Indians had the highest prevalence of H. pylori infection among other ethnic groups (Malays= 8.6 %, Chinese= 24.3 %, Indians= 33.9%). cagM and cagT were the most predominant genes found (63.4% for each), followed by cagA (62.2 %), cagE (48.2%), cag6-7 (46.3%), cag10 (42.1%), cag13 (4.9%) and IS605 (3.7%). No significant association was found between H. pylori infection and H. pylori genes with ethnic groups or clinical outcomes. Indians who had a combination of cagA/ E/M genes of H. pylori were likely to be associated with 21-time of having non-ulcer dyspepsia (NUD) than peptic ulcer disease (PUD). Therefore, these genes may serve as useful markers in predicting the clinical presentation of a H. pylori infection among Indians in our studied population. Hence, this preliminary data might explain why Indians have a low prevalence of gastric cancer and peptic ulcer disease despite having persistently high prevalence of H. pylori infection for many decades (“Indian enigma�) in Malaysian patients.
format Article
author Hamat, Rukman Awang
Embran, Nor Amalina
Sekawi, Zamberi
Osman, Malina
Hanafiah, Alfizah
Abdul Manaf, Mohd Rizal
Adnan, Aminuddin
Mohamed, Ramelah
spellingShingle Hamat, Rukman Awang
Embran, Nor Amalina
Sekawi, Zamberi
Osman, Malina
Hanafiah, Alfizah
Abdul Manaf, Mohd Rizal
Adnan, Aminuddin
Mohamed, Ramelah
Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
author_facet Hamat, Rukman Awang
Embran, Nor Amalina
Sekawi, Zamberi
Osman, Malina
Hanafiah, Alfizah
Abdul Manaf, Mohd Rizal
Adnan, Aminuddin
Mohamed, Ramelah
author_sort Hamat, Rukman Awang
title Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
title_short Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
title_full Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
title_fullStr Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
title_full_unstemmed Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
title_sort ethnic differences in the prevalence, clinical outcome and cag pathogenicity island (cagpai) virulence gene profiles of helicobacter pylori strains from malaysia
publisher Universiti Putra Malaysia Press
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf
http://psasir.upm.edu.my/id/eprint/22165/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2036%20(4)%20Nov.%202013/01%20Page%20289-298.pdf
_version_ 1643827747784491008
score 13.211869

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