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Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects

Prostate cancer has become the second leading cancer among men across ethnic groups in the world. Since it is influenced by a complex genetics that may affect the level of susceptibility for the development of the disease, four Y-linked short tandem repeats (STRs), DYS388, DYS435, DYS437, and DYS439...

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Main Authors: Ismail, Patimah, Nargesi, Mirsaed Miri, Abdul Kadir, Azrul
Format: Conference or Workshop Item
Language:English
Published: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014
Online Access:http://psasir.upm.edu.my/id/eprint/20168/1/ABSTRACT%20CAC%202014_2%20medic%2020.pdf
http://psasir.upm.edu.my/id/eprint/20168/
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spelling my.upm.eprints.201682016-04-26T04:17:58Z http://psasir.upm.edu.my/id/eprint/20168/ Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects Ismail, Patimah Nargesi, Mirsaed Miri Abdul Kadir, Azrul Prostate cancer has become the second leading cancer among men across ethnic groups in the world. Since it is influenced by a complex genetics that may affect the level of susceptibility for the development of the disease, four Y-linked short tandem repeats (STRs), DYS388, DYS435, DYS437, and DYS439 were genotyped to compare Malaysian prostate cancer patients and normal controls males. A total of 175 subjects comprising 84 patients and 91 healthy individuals from three major ethnics were recruited. Multiplex PCR was optimized to co-amplify all four DYS loci. All samples were genotyped for alleles of four DYS loci using a Genetic Analysis System. Result showed that allele 10 (A) of DYS388 had a significantly lower incidence towards disease than other alleles of this locus, while allele 12 (C) of DYS388 and allele 14 (E) of DYS439 showed a significantly higher risk to develop prostate cancer compared to other alleles of these loci. Moreover, among 47 different haplotypes comprising different alleles of four DYS loci found in the overall study samples, it is noticed that AABC and CAAA showed a lower and higher frequency among cases than controls, respectively. As a conclusion, Malaysian males who belong to Y-lineages with either allele 12 of DYS388, allele 14 of DYS439, or haplotype CAAA tend to develop prostate cancer. Meanwhile, those belonging to Y-lineages with allele 10 of DYS388 or haplotype AABC are more resistant to the disease. Thus, it is suggested that genetic elements give an influence on the development of prostate cancer. UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/20168/1/ABSTRACT%20CAC%202014_2%20medic%2020.pdf Ismail, Patimah and Nargesi, Mirsaed Miri and Abdul Kadir, Azrul (2014) Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects. In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. .
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Prostate cancer has become the second leading cancer among men across ethnic groups in the world. Since it is influenced by a complex genetics that may affect the level of susceptibility for the development of the disease, four Y-linked short tandem repeats (STRs), DYS388, DYS435, DYS437, and DYS439 were genotyped to compare Malaysian prostate cancer patients and normal controls males. A total of 175 subjects comprising 84 patients and 91 healthy individuals from three major ethnics were recruited. Multiplex PCR was optimized to co-amplify all four DYS loci. All samples were genotyped for alleles of four DYS loci using a Genetic Analysis System. Result showed that allele 10 (A) of DYS388 had a significantly lower incidence towards disease than other alleles of this locus, while allele 12 (C) of DYS388 and allele 14 (E) of DYS439 showed a significantly higher risk to develop prostate cancer compared to other alleles of these loci. Moreover, among 47 different haplotypes comprising different alleles of four DYS loci found in the overall study samples, it is noticed that AABC and CAAA showed a lower and higher frequency among cases than controls, respectively. As a conclusion, Malaysian males who belong to Y-lineages with either allele 12 of DYS388, allele 14 of DYS439, or haplotype CAAA tend to develop prostate cancer. Meanwhile, those belonging to Y-lineages with allele 10 of DYS388 or haplotype AABC are more resistant to the disease. Thus, it is suggested that genetic elements give an influence on the development of prostate cancer.
format Conference or Workshop Item
author Ismail, Patimah
Nargesi, Mirsaed Miri
Abdul Kadir, Azrul
spellingShingle Ismail, Patimah
Nargesi, Mirsaed Miri
Abdul Kadir, Azrul
Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
author_facet Ismail, Patimah
Nargesi, Mirsaed Miri
Abdul Kadir, Azrul
author_sort Ismail, Patimah
title Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
title_short Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
title_full Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
title_fullStr Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
title_full_unstemmed Linkage analysis between prostate cancer occurrence and Y-chromosomal DYS loci in Malaysian male subjects
title_sort linkage analysis between prostate cancer occurrence and y-chromosomal dys loci in malaysian male subjects
publisher UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/20168/1/ABSTRACT%20CAC%202014_2%20medic%2020.pdf
http://psasir.upm.edu.my/id/eprint/20168/
_version_ 1643827247380955136
score 13.211869

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