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Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.

Background: The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT). Methods: This study explored the role of p53, p16, bcl-2, ki-67, c-myc, Rb and EGFR,...

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Main Authors: Abdulamir, Ahmed Sahib, Hafidh, Rand Riadh, Kadhim, Haider Sabah, Abubakar, Fatimah
Format: Article
Language:English
Published: BioMed Central 2009
Online Access:http://psasir.upm.edu.my/id/eprint/17491/1/Tumor%20markers%20of%20bladder%20cancer.pdf
http://psasir.upm.edu.my/id/eprint/17491/
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spelling my.upm.eprints.174912015-11-30T04:48:45Z http://psasir.upm.edu.my/id/eprint/17491/ Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors. Abdulamir, Ahmed Sahib Hafidh, Rand Riadh Kadhim, Haider Sabah Abubakar, Fatimah Background: The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT). Methods: This study explored the role of p53, p16, bcl-2, ki-67, c-myc, Rb and EGFR, by using Immunohistochemistry assay, in 45 SBT and 39 NSBT patients in comparison with 16 schistosomal chronic cystitis (SC), 28 non-schistosomal chronic cystitis (NSC), and 20 normal control (CTL) subjects. The studied markers in SBT and NSBT were correlated with different clinicopathological criteria namely, tumor histopathology, grading, invasiveness, stage, and presentation of the disease. Results: SBT was associated with high grade invasive squamous cell carcinoma (SCC) while NSBT was associated with lower grade less invasive transitional cell carcinoma (TCC). The expression of p53, bcl-2, c-myc, and EGFR was higher in SBT than in NSBT while Rb was higher in NSBT than in SBT. However, p16 and ki-67 were not different between SBT and NSBT. The profile of molecular markers in SC was similar to NSC except for EGFR which was higher in SC than in NSC. Both SC and NSC showed higher level of p53, bcl-2, ki-67, and EGFR than in CTL group while p16, Rb, and c-myc were not different. p53 was associated with high grade SCC in both SBT and NSBT. Bcl-2 was associated with high grade invasive tumors in SBT and NSBT. P16 was associated with low grade, late stage, and recurrent SBT and high grade, invasive, late stage, and recurrent NSBT. Rb was associated with SCC in SBT, invasive tumors in NSBT, and late stage and recurrent presentation in both SBT and NSBT. C-myc was associated with high grade, invasive, and late stage SBT and SCC, high grade, invasive, and late stage NSBT. EGFR was associated with invasive SCC in SBT and invasive, high grade, and late stage TCC in NSBT. ki-67 was associated with invasive SBT and high grade late stage NSBT. Conclusion: SBT and NSBT showed distinct molecular profile of tumor development and progression which can be taken into consideration in fine adjusting the anti-cancer therapy for SBT and NSBT. BioMed Central 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17491/1/Tumor%20markers%20of%20bladder%20cancer.pdf Abdulamir, Ahmed Sahib and Hafidh, Rand Riadh and Kadhim, Haider Sabah and Abubakar, Fatimah (2009) Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors. Journal of Experimental and Clinical Cancer Research, 28 (27). pp. 1-14. ISSN 1756-9966 10.1186/1756-9966-28-27
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT). Methods: This study explored the role of p53, p16, bcl-2, ki-67, c-myc, Rb and EGFR, by using Immunohistochemistry assay, in 45 SBT and 39 NSBT patients in comparison with 16 schistosomal chronic cystitis (SC), 28 non-schistosomal chronic cystitis (NSC), and 20 normal control (CTL) subjects. The studied markers in SBT and NSBT were correlated with different clinicopathological criteria namely, tumor histopathology, grading, invasiveness, stage, and presentation of the disease. Results: SBT was associated with high grade invasive squamous cell carcinoma (SCC) while NSBT was associated with lower grade less invasive transitional cell carcinoma (TCC). The expression of p53, bcl-2, c-myc, and EGFR was higher in SBT than in NSBT while Rb was higher in NSBT than in SBT. However, p16 and ki-67 were not different between SBT and NSBT. The profile of molecular markers in SC was similar to NSC except for EGFR which was higher in SC than in NSC. Both SC and NSC showed higher level of p53, bcl-2, ki-67, and EGFR than in CTL group while p16, Rb, and c-myc were not different. p53 was associated with high grade SCC in both SBT and NSBT. Bcl-2 was associated with high grade invasive tumors in SBT and NSBT. P16 was associated with low grade, late stage, and recurrent SBT and high grade, invasive, late stage, and recurrent NSBT. Rb was associated with SCC in SBT, invasive tumors in NSBT, and late stage and recurrent presentation in both SBT and NSBT. C-myc was associated with high grade, invasive, and late stage SBT and SCC, high grade, invasive, and late stage NSBT. EGFR was associated with invasive SCC in SBT and invasive, high grade, and late stage TCC in NSBT. ki-67 was associated with invasive SBT and high grade late stage NSBT. Conclusion: SBT and NSBT showed distinct molecular profile of tumor development and progression which can be taken into consideration in fine adjusting the anti-cancer therapy for SBT and NSBT.
format Article
author Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Kadhim, Haider Sabah
Abubakar, Fatimah
spellingShingle Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Kadhim, Haider Sabah
Abubakar, Fatimah
Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
author_facet Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Kadhim, Haider Sabah
Abubakar, Fatimah
author_sort Abdulamir, Ahmed Sahib
title Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
title_short Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
title_full Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
title_fullStr Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
title_full_unstemmed Tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
title_sort tumor markers of bladder cancer : the schistosomal bladder tumors versus non-schistosomal bladder tumors.
publisher BioMed Central
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/17491/1/Tumor%20markers%20of%20bladder%20cancer.pdf
http://psasir.upm.edu.my/id/eprint/17491/
_version_ 1643826533590106112
score 13.211869

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