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Toxicology study of vanillin on rats via oral and intra-peritoneal administration

Vanillin is useful as anti-sickle cell anemia, anti-mutagen and anti-bacteria agent. However, vanillin must be administered at high concentration and cannot be oxidized by the upper gastrointestinal track of patients to be medically effective. In this study, we assessed the toxic effect of vanillin...

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Main Authors: Ismail, Maznah, Saiful Yazan, Latifah, Ho, Ket Li, Ismail, Norsharina
Format: Article
Language:English
English
Published: Elsevier 2010
Online Access:http://psasir.upm.edu.my/id/eprint/17453/1/Toxicology%20study%20of%20vanillin%20on%20rats%20via%20oral%20and%20intra.pdf
http://psasir.upm.edu.my/id/eprint/17453/
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spelling my.upm.eprints.174532015-09-28T01:10:50Z http://psasir.upm.edu.my/id/eprint/17453/ Toxicology study of vanillin on rats via oral and intra-peritoneal administration Ismail, Maznah Saiful Yazan, Latifah Ho, Ket Li Ismail, Norsharina Vanillin is useful as anti-sickle cell anemia, anti-mutagen and anti-bacteria agent. However, vanillin must be administered at high concentration and cannot be oxidized by the upper gastrointestinal track of patients to be medically effective. In this study, we assessed the toxic effect of vanillin when administered in an un-oxidized form at high concentrations (150 and 300 mg/kg) via oral and intra-peritoneal injection. It was found that 300 mg/kg vanillin injection caused the rats to be unconscious without exerting any toxic effect on blood cells, kidney and liver. Besides, it showed blood protective property. Further analysis with GenomeLab GeXP genetic system on brain tissues showed that the expression of most xenobiotic metabolism, cell progression, tumor suppressor, DNA damage and inflammation genes were maintained at normal level. However, the expression of a few xenobiotic metabolism, cell cycle arrest and apoptosis genes were up-regulated by 5% ethanol injection. Nevertheless, when 5% ethanol was injected with the presence of vanillin, the expression was back to normal level. It is postulated that vanillin might have neuro-protective property. In conclusion, vanillin is not toxic at high concentration in both oral and intra-peritoneal injection and could provide blood and brain protective properties. Elsevier 2010-08-31 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17453/1/Toxicology%20study%20of%20vanillin%20on%20rats%20via%20oral%20and%20intra.pdf Ismail, Maznah and Saiful Yazan, Latifah and Ho, Ket Li and Ismail, Norsharina (2010) Toxicology study of vanillin on rats via oral and intra-peritoneal administration. Food and Chemical Toxicology, 49 (1). pp. 25-30. ISSN 0278-6915, ESSN: 1873-6351 10.1016/j.fct.2010.08.023 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Vanillin is useful as anti-sickle cell anemia, anti-mutagen and anti-bacteria agent. However, vanillin must be administered at high concentration and cannot be oxidized by the upper gastrointestinal track of patients to be medically effective. In this study, we assessed the toxic effect of vanillin when administered in an un-oxidized form at high concentrations (150 and 300 mg/kg) via oral and intra-peritoneal injection. It was found that 300 mg/kg vanillin injection caused the rats to be unconscious without exerting any toxic effect on blood cells, kidney and liver. Besides, it showed blood protective property. Further analysis with GenomeLab GeXP genetic system on brain tissues showed that the expression of most xenobiotic metabolism, cell progression, tumor suppressor, DNA damage and inflammation genes were maintained at normal level. However, the expression of a few xenobiotic metabolism, cell cycle arrest and apoptosis genes were up-regulated by 5% ethanol injection. Nevertheless, when 5% ethanol was injected with the presence of vanillin, the expression was back to normal level. It is postulated that vanillin might have neuro-protective property. In conclusion, vanillin is not toxic at high concentration in both oral and intra-peritoneal injection and could provide blood and brain protective properties.
format Article
author Ismail, Maznah
Saiful Yazan, Latifah
Ho, Ket Li
Ismail, Norsharina
spellingShingle Ismail, Maznah
Saiful Yazan, Latifah
Ho, Ket Li
Ismail, Norsharina
Toxicology study of vanillin on rats via oral and intra-peritoneal administration
author_facet Ismail, Maznah
Saiful Yazan, Latifah
Ho, Ket Li
Ismail, Norsharina
author_sort Ismail, Maznah
title Toxicology study of vanillin on rats via oral and intra-peritoneal administration
title_short Toxicology study of vanillin on rats via oral and intra-peritoneal administration
title_full Toxicology study of vanillin on rats via oral and intra-peritoneal administration
title_fullStr Toxicology study of vanillin on rats via oral and intra-peritoneal administration
title_full_unstemmed Toxicology study of vanillin on rats via oral and intra-peritoneal administration
title_sort toxicology study of vanillin on rats via oral and intra-peritoneal administration
publisher Elsevier
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/17453/1/Toxicology%20study%20of%20vanillin%20on%20rats%20via%20oral%20and%20intra.pdf
http://psasir.upm.edu.my/id/eprint/17453/
_version_ 1643826521507364864
score 13.223943

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