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In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model

Cancer nanotherapeutics are progressing rapidly with innovative drug delivery systems to replace conventional delivery systems. Although, antitumor activity of zerumbone (ZER) has been reported, there has been no available information of ZER-loaded nanostructured lipid carrier (NLC) affects murine l...

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Main Authors: Rahman, Heshu Sulaiman, Abdullah, R., Othman, Hemn Hassan, Chartrand, Max Stanley, Abdul, Ahmad Bustamam, Ajdari, Zahra, Hosseinpour, Mahnaz, Abdul Samad, Nozlena
Format: Conference or Workshop Item
Language:English
Published: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014
Online Access:http://psasir.upm.edu.my/id/eprint/17228/1/ABSTRACT%20CAC%202014_2%20medic%2012.pdf
http://psasir.upm.edu.my/id/eprint/17228/
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spelling my.upm.eprints.172282016-04-26T03:53:42Z http://psasir.upm.edu.my/id/eprint/17228/ In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model Rahman, Heshu Sulaiman Abdullah, R. Othman, Hemn Hassan Chartrand, Max Stanley Abdul, Ahmad Bustamam Ajdari, Zahra Hosseinpour, Mahnaz Abdul Samad, Nozlena Cancer nanotherapeutics are progressing rapidly with innovative drug delivery systems to replace conventional delivery systems. Although, antitumor activity of zerumbone (ZER) has been reported, there has been no available information of ZER-loaded nanostructured lipid carrier (NLC) affects murine leukemia cells in vivo. In a previous study, ZER was incorporated into NLC by high pressure homogenization (HPH) technique. Physicochemical characterization included particle size, polydipersity index, zeta potential, pH, entrapment efficiency, loading capacity, stability study, and in vitro drug release, as well as physicochemical stability after being autoclaved and stored at 4˚C, 25˚C and 40˚C for 1 month, were examined. In this study, in vivo effects of ZER-NLC on murine leukemia WEHI-3B cells were investigated. The outcomes of histopathology, TEM and TUNEL assays of BALB/c leukemia mice revealed that the number of leukemia cells were significantly (P < 0.05) decreased in spleen tissue after four weeks of oral administration of ZER-NLC. In conclusion, NLC is suggested as a promising carrier for ZER oral delivery. UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17228/1/ABSTRACT%20CAC%202014_2%20medic%2012.pdf Rahman, Heshu Sulaiman and Abdullah, R. and Othman, Hemn Hassan and Chartrand, Max Stanley and Abdul, Ahmad Bustamam and Ajdari, Zahra and Hosseinpour, Mahnaz and Abdul Samad, Nozlena (2014) In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model. In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. .
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Cancer nanotherapeutics are progressing rapidly with innovative drug delivery systems to replace conventional delivery systems. Although, antitumor activity of zerumbone (ZER) has been reported, there has been no available information of ZER-loaded nanostructured lipid carrier (NLC) affects murine leukemia cells in vivo. In a previous study, ZER was incorporated into NLC by high pressure homogenization (HPH) technique. Physicochemical characterization included particle size, polydipersity index, zeta potential, pH, entrapment efficiency, loading capacity, stability study, and in vitro drug release, as well as physicochemical stability after being autoclaved and stored at 4˚C, 25˚C and 40˚C for 1 month, were examined. In this study, in vivo effects of ZER-NLC on murine leukemia WEHI-3B cells were investigated. The outcomes of histopathology, TEM and TUNEL assays of BALB/c leukemia mice revealed that the number of leukemia cells were significantly (P < 0.05) decreased in spleen tissue after four weeks of oral administration of ZER-NLC. In conclusion, NLC is suggested as a promising carrier for ZER oral delivery.
format Conference or Workshop Item
author Rahman, Heshu Sulaiman
Abdullah, R.
Othman, Hemn Hassan
Chartrand, Max Stanley
Abdul, Ahmad Bustamam
Ajdari, Zahra
Hosseinpour, Mahnaz
Abdul Samad, Nozlena
spellingShingle Rahman, Heshu Sulaiman
Abdullah, R.
Othman, Hemn Hassan
Chartrand, Max Stanley
Abdul, Ahmad Bustamam
Ajdari, Zahra
Hosseinpour, Mahnaz
Abdul Samad, Nozlena
In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
author_facet Rahman, Heshu Sulaiman
Abdullah, R.
Othman, Hemn Hassan
Chartrand, Max Stanley
Abdul, Ahmad Bustamam
Ajdari, Zahra
Hosseinpour, Mahnaz
Abdul Samad, Nozlena
author_sort Rahman, Heshu Sulaiman
title In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
title_short In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
title_full In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
title_fullStr In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
title_full_unstemmed In vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
title_sort in vivo assessment of nanostructured lipid carrier for oral delivery of zerumbone in leukemic mice model
publisher UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/17228/1/ABSTRACT%20CAC%202014_2%20medic%2012.pdf
http://psasir.upm.edu.my/id/eprint/17228/
_version_ 1643826452504772608
score 13.211869

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