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Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity

Zerumbone (ZER), a sesquiterpene phytochemical isolated from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia. The anticancer effects of ZER has been previously reported at our Laboratory, which used MTT assay on human cancer cells of several cell lines su...

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Main Authors: Abdul Samad, Nozlena, Abdul, Ahmad Bustamam, Abdullah, Rasedee, Tengku Ibrahim, Tengku Azmi, Rahman, Heshu Sulaiman, Othman, Hemn Hassan, Yeap, Swee Keong
Format: Conference or Workshop Item
Language:English
Published: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014
Online Access:http://psasir.upm.edu.my/id/eprint/17153/1/ABSTRACT%20CAC%202014_2%20medic%2016.pdf
http://psasir.upm.edu.my/id/eprint/17153/
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spelling my.upm.eprints.171532016-04-26T04:09:52Z http://psasir.upm.edu.my/id/eprint/17153/ Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity Abdul Samad, Nozlena Abdul, Ahmad Bustamam Abdullah, Rasedee Tengku Ibrahim, Tengku Azmi Rahman, Heshu Sulaiman Othman, Hemn Hassan Yeap, Swee Keong Zerumbone (ZER), a sesquiterpene phytochemical isolated from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia. The anticancer effects of ZER has been previously reported at our Laboratory, which used MTT assay on human cancer cells of several cell lines such as cervix (HeLa), leukemia (jurkat) and breast (MCF-7). ZER anti-cancer properties were found to be in equivalent with cisplatin, a commercial anticancer drug used preferentially in treating cervical cancer in humans. In this study, MTT assay was carried to obtain the IC50 value of zerumbone towards HepG2 and normal liver, WRL-68 cell lines. The cytotoxicity analysis on HepG2 cells revealed that the IC50 is 6.20μg/ml. ZER showed no apparent cytotoxicity response towards WRL-68 cell lines. Morphological analysis for apoptosis detection by using inverted microscope and SEM have produced typical apoptotic characteristic. It showed that zerumbone has antiproliferative activity towards liver cancer cell by its ability to induce apoptosis. The outcome of this study demonstrates that zerumbone has the ability to increased efficacy with limited toxicity in liver cancer treatment. UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17153/1/ABSTRACT%20CAC%202014_2%20medic%2016.pdf Abdul Samad, Nozlena and Abdul, Ahmad Bustamam and Abdullah, Rasedee and Tengku Ibrahim, Tengku Azmi and Rahman, Heshu Sulaiman and Othman, Hemn Hassan and Yeap, Swee Keong (2014) Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity. In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. .
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Zerumbone (ZER), a sesquiterpene phytochemical isolated from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia. The anticancer effects of ZER has been previously reported at our Laboratory, which used MTT assay on human cancer cells of several cell lines such as cervix (HeLa), leukemia (jurkat) and breast (MCF-7). ZER anti-cancer properties were found to be in equivalent with cisplatin, a commercial anticancer drug used preferentially in treating cervical cancer in humans. In this study, MTT assay was carried to obtain the IC50 value of zerumbone towards HepG2 and normal liver, WRL-68 cell lines. The cytotoxicity analysis on HepG2 cells revealed that the IC50 is 6.20μg/ml. ZER showed no apparent cytotoxicity response towards WRL-68 cell lines. Morphological analysis for apoptosis detection by using inverted microscope and SEM have produced typical apoptotic characteristic. It showed that zerumbone has antiproliferative activity towards liver cancer cell by its ability to induce apoptosis. The outcome of this study demonstrates that zerumbone has the ability to increased efficacy with limited toxicity in liver cancer treatment.
format Conference or Workshop Item
author Abdul Samad, Nozlena
Abdul, Ahmad Bustamam
Abdullah, Rasedee
Tengku Ibrahim, Tengku Azmi
Rahman, Heshu Sulaiman
Othman, Hemn Hassan
Yeap, Swee Keong
spellingShingle Abdul Samad, Nozlena
Abdul, Ahmad Bustamam
Abdullah, Rasedee
Tengku Ibrahim, Tengku Azmi
Rahman, Heshu Sulaiman
Othman, Hemn Hassan
Yeap, Swee Keong
Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
author_facet Abdul Samad, Nozlena
Abdul, Ahmad Bustamam
Abdullah, Rasedee
Tengku Ibrahim, Tengku Azmi
Rahman, Heshu Sulaiman
Othman, Hemn Hassan
Yeap, Swee Keong
author_sort Abdul Samad, Nozlena
title Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
title_short Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
title_full Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
title_fullStr Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
title_full_unstemmed Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
title_sort cytotoxicty of zerumbone against liver cancer cell lines (hepg2) via apoptosis activity
publisher UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/17153/1/ABSTRACT%20CAC%202014_2%20medic%2016.pdf
http://psasir.upm.edu.my/id/eprint/17153/
_version_ 1643826430536056832
score 13.211869

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