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The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.

Nasopharyngeal carcinoma (NPC) and other head and neck cancer (HNCA) types show a great epidemiological variation in different regions of the world. NPC has multifactorial etiology and many interacting risk factors are involved in NPC development mainly Epstein Barr virus (EBV). There is a need to s...

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Main Authors: Abdulamir, Ahmed Sahib, Hafidh, Rand Riadh, Abdulmuhaimen, N., Abu Bakar, Fatimah, Abbas, Kassim Ali
Format: Article
Language:English
English
Published: BioMed Central 2008
Online Access:http://psasir.upm.edu.my/id/eprint/17061/1/The%20distinctive%20profile%20of%20risk%20factors%20of%20nasopharyngeal%20carcinoma%20in%20comparison%20with%20other%20head%20and%20neck%20cancer%20types.pdf
http://psasir.upm.edu.my/id/eprint/17061/
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spelling my.upm.eprints.170612015-12-07T06:54:58Z http://psasir.upm.edu.my/id/eprint/17061/ The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types. Abdulamir, Ahmed Sahib Hafidh, Rand Riadh Abdulmuhaimen, N. Abu Bakar, Fatimah Abbas, Kassim Ali Nasopharyngeal carcinoma (NPC) and other head and neck cancer (HNCA) types show a great epidemiological variation in different regions of the world. NPC has multifactorial etiology and many interacting risk factors are involved in NPC development mainly Epstein Barr virus (EBV). There is a need to scrutinize the complicated network of risk factors affecting NPC and how far they are different from that of other HNCA types.122 HNCA patients and 100 control subjects were studied in the region of the Middle East. Three types of HNCA were involved in our study, NPC, carcinoma of larynx (CL), and hypopharyngeal carcinoma (HPC). The risk factors studied were the level of EBV serum IgG and IgA antibodies measured by ELISA, age, sex, smoking, alcohol intake, histology, and family history of the disease.EBV serum level of IgG and IgA antibodies was higher in NPC than CL, HPC, and control groups (p < 0.01). NPC was associated with lymphoepithelioma (LE) tumors, males, regular alcohol intake, and regular smoking while CL and HPC were not (p < 0.05). CL and HPC were associated with SCC tumors (p < 0.05). Furthermore, NPC, unlike CL and HPC groups, was not affected by the positive family history of HNCA (p > 0.05). The serum levels of EBV IgG and IgA antibodies were higher in LE tumors, regular smokers, younger patients, and negative family history groups of NPC patients than SCC tumors, non-regular smokers, older patients and positive family history groups respectively (p < 0.05) while this was not found in the regular alcoholics (p > 0.05).It was concluded that risk factors of NPC deviate much from that of other HNCA. EBV, smoking, alcohol intake, LE tumors, male patient, and age > 54 years were hot risk factors of NPC while SCC and positive family history of the disease were not. Earlier incidence, smoking, LE tumors, and negative family history of the disease in NPC patients were associated much clearly with EBV. It is proposed that determining the correct risk factors of NPC is vital in assigning the correct risk groups of NPC which helps the early detection and screening of NPC. BioMed Central 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17061/1/The%20distinctive%20profile%20of%20risk%20factors%20of%20nasopharyngeal%20carcinoma%20in%20comparison%20with%20other%20head%20and%20neck%20cancer%20types.pdf Abdulamir, Ahmed Sahib and Hafidh, Rand Riadh and Abdulmuhaimen, N. and Abu Bakar, Fatimah and Abbas, Kassim Ali (2008) The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types. BMC Public Health, 8 (400). pp. 1-41. ISSN 1471-2458 10.1186/1471-2458-8-400 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Nasopharyngeal carcinoma (NPC) and other head and neck cancer (HNCA) types show a great epidemiological variation in different regions of the world. NPC has multifactorial etiology and many interacting risk factors are involved in NPC development mainly Epstein Barr virus (EBV). There is a need to scrutinize the complicated network of risk factors affecting NPC and how far they are different from that of other HNCA types.122 HNCA patients and 100 control subjects were studied in the region of the Middle East. Three types of HNCA were involved in our study, NPC, carcinoma of larynx (CL), and hypopharyngeal carcinoma (HPC). The risk factors studied were the level of EBV serum IgG and IgA antibodies measured by ELISA, age, sex, smoking, alcohol intake, histology, and family history of the disease.EBV serum level of IgG and IgA antibodies was higher in NPC than CL, HPC, and control groups (p < 0.01). NPC was associated with lymphoepithelioma (LE) tumors, males, regular alcohol intake, and regular smoking while CL and HPC were not (p < 0.05). CL and HPC were associated with SCC tumors (p < 0.05). Furthermore, NPC, unlike CL and HPC groups, was not affected by the positive family history of HNCA (p > 0.05). The serum levels of EBV IgG and IgA antibodies were higher in LE tumors, regular smokers, younger patients, and negative family history groups of NPC patients than SCC tumors, non-regular smokers, older patients and positive family history groups respectively (p < 0.05) while this was not found in the regular alcoholics (p > 0.05).It was concluded that risk factors of NPC deviate much from that of other HNCA. EBV, smoking, alcohol intake, LE tumors, male patient, and age > 54 years were hot risk factors of NPC while SCC and positive family history of the disease were not. Earlier incidence, smoking, LE tumors, and negative family history of the disease in NPC patients were associated much clearly with EBV. It is proposed that determining the correct risk factors of NPC is vital in assigning the correct risk groups of NPC which helps the early detection and screening of NPC.
format Article
author Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Abdulmuhaimen, N.
Abu Bakar, Fatimah
Abbas, Kassim Ali
spellingShingle Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Abdulmuhaimen, N.
Abu Bakar, Fatimah
Abbas, Kassim Ali
The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
author_facet Abdulamir, Ahmed Sahib
Hafidh, Rand Riadh
Abdulmuhaimen, N.
Abu Bakar, Fatimah
Abbas, Kassim Ali
author_sort Abdulamir, Ahmed Sahib
title The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
title_short The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
title_full The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
title_fullStr The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
title_full_unstemmed The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
title_sort distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types.
publisher BioMed Central
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/17061/1/The%20distinctive%20profile%20of%20risk%20factors%20of%20nasopharyngeal%20carcinoma%20in%20comparison%20with%20other%20head%20and%20neck%20cancer%20types.pdf
http://psasir.upm.edu.my/id/eprint/17061/
_version_ 1643826401906786304
score 13.211869

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