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Serotonergic properties of the roots of Clerodendron capitatum

The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreate...

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Main Authors: Abdelwahab, Siddig Ibrahim, Mohamed, Abdel Wahab Hassan, Mohamed, Osama Yousif, Elhassan Taha, Manal Mohamed, Abdul, Ahmad Bustamam, Al-Zubairi, Adel Sharaf
Format: Article
Language:English
Published: Science Publications 2008
Online Access:http://psasir.upm.edu.my/id/eprint/16678/1/ajbbsp.2008.425.430.pdf
http://psasir.upm.edu.my/id/eprint/16678/
http://www.thescipub.com/abstract/?doi=ajbbsp.2008.425.430
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spelling my.upm.eprints.166782017-12-04T04:03:08Z http://psasir.upm.edu.my/id/eprint/16678/ Serotonergic properties of the roots of Clerodendron capitatum Abdelwahab, Siddig Ibrahim Mohamed, Abdel Wahab Hassan Mohamed, Osama Yousif Elhassan Taha, Manal Mohamed Abdul, Ahmad Bustamam Al-Zubairi, Adel Sharaf The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists. Science Publications 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16678/1/ajbbsp.2008.425.430.pdf Abdelwahab, Siddig Ibrahim and Mohamed, Abdel Wahab Hassan and Mohamed, Osama Yousif and Elhassan Taha, Manal Mohamed and Abdul, Ahmad Bustamam and Al-Zubairi, Adel Sharaf (2008) Serotonergic properties of the roots of Clerodendron capitatum. American Journal of Biochemistry and Biotechnology, 4 (4). pp. 425-430. ISSN 1553-3468; ESSN: 1558-6332 http://www.thescipub.com/abstract/?doi=ajbbsp.2008.425.430 10.3844/ajbbsp.2008.425.430
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.
format Article
author Abdelwahab, Siddig Ibrahim
Mohamed, Abdel Wahab Hassan
Mohamed, Osama Yousif
Elhassan Taha, Manal Mohamed
Abdul, Ahmad Bustamam
Al-Zubairi, Adel Sharaf
spellingShingle Abdelwahab, Siddig Ibrahim
Mohamed, Abdel Wahab Hassan
Mohamed, Osama Yousif
Elhassan Taha, Manal Mohamed
Abdul, Ahmad Bustamam
Al-Zubairi, Adel Sharaf
Serotonergic properties of the roots of Clerodendron capitatum
author_facet Abdelwahab, Siddig Ibrahim
Mohamed, Abdel Wahab Hassan
Mohamed, Osama Yousif
Elhassan Taha, Manal Mohamed
Abdul, Ahmad Bustamam
Al-Zubairi, Adel Sharaf
author_sort Abdelwahab, Siddig Ibrahim
title Serotonergic properties of the roots of Clerodendron capitatum
title_short Serotonergic properties of the roots of Clerodendron capitatum
title_full Serotonergic properties of the roots of Clerodendron capitatum
title_fullStr Serotonergic properties of the roots of Clerodendron capitatum
title_full_unstemmed Serotonergic properties of the roots of Clerodendron capitatum
title_sort serotonergic properties of the roots of clerodendron capitatum
publisher Science Publications
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/16678/1/ajbbsp.2008.425.430.pdf
http://psasir.upm.edu.my/id/eprint/16678/
http://www.thescipub.com/abstract/?doi=ajbbsp.2008.425.430
_version_ 1643826285569376256
score 13.211869

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