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Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia

Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 label...

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Main Authors: Hassan, Muhammad Hishar, Abu Bakar, Suharzelim, Che A. Halim, Khairul Najah, Idris, Jaleezah, Ahmad Saad, Fathinul Fikri, Nordin, Abdul Jalil
Format: Article
Language:English
Published: Bentham Science Publishers 2016
Online Access:http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/16490/
http://benthamscience.com/journals/current-medical-imaging-reviews/volume/12/issue/1/page/67/
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spelling my.upm.eprints.164902016-06-08T01:54:50Z http://psasir.upm.edu.my/id/eprint/16490/ Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia Hassan, Muhammad Hishar Abu Bakar, Suharzelim Che A. Halim, Khairul Najah Idris, Jaleezah Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 labelled prostate specific membrane antigen (68Ga-PSMA) for the diagnosis of prostate cancer in positron emission tomography / computed tomography (PET/CT) modality, the challenges in the staging and detection accuracy would promise a better management strategy for patients. This article presents the synthesis of 18F-fluorocholine and a convenient method for quality control analysis of 18F-fluorocholine. In addition, the aim of this research work is to assist local Good Manufacturing Practice (GMP) radiopharmaceutical laboratories that routinely produce 18F-fluorodeoxyglucose (18F-FDG), to start producing 18F-fluorocholine as a tracer for prostate cancer imaging. Bentham Science Publishers 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf Hassan, Muhammad Hishar and Abu Bakar, Suharzelim and Che A. Halim, Khairul Najah and Idris, Jaleezah and Ahmad Saad, Fathinul Fikri and Nordin, Abdul Jalil (2016) Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia. Current Medical Imaging Reviews, 12 (1). pp. 67-74. ISSN 1573-4056; ESSN: 1875-6603 http://benthamscience.com/journals/current-medical-imaging-reviews/volume/12/issue/1/page/67/ 10.2174/1573405612666151203203739
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Prostate cancer is ranked fourth among the most prevalent cancers in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. With the emergence of reputable imaging tracers such as fluorine-18-labelled choline (18F-fluorocholine) and gallium-68 labelled prostate specific membrane antigen (68Ga-PSMA) for the diagnosis of prostate cancer in positron emission tomography / computed tomography (PET/CT) modality, the challenges in the staging and detection accuracy would promise a better management strategy for patients. This article presents the synthesis of 18F-fluorocholine and a convenient method for quality control analysis of 18F-fluorocholine. In addition, the aim of this research work is to assist local Good Manufacturing Practice (GMP) radiopharmaceutical laboratories that routinely produce 18F-fluorodeoxyglucose (18F-FDG), to start producing 18F-fluorocholine as a tracer for prostate cancer imaging.
format Article
author Hassan, Muhammad Hishar
Abu Bakar, Suharzelim
Che A. Halim, Khairul Najah
Idris, Jaleezah
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
spellingShingle Hassan, Muhammad Hishar
Abu Bakar, Suharzelim
Che A. Halim, Khairul Najah
Idris, Jaleezah
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
author_facet Hassan, Muhammad Hishar
Abu Bakar, Suharzelim
Che A. Halim, Khairul Najah
Idris, Jaleezah
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
author_sort Hassan, Muhammad Hishar
title Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
title_short Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
title_full Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
title_fullStr Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
title_full_unstemmed Synthesis of fluorine-18-labelled choline (18F-fluorocholine): towards an early and accurate management of prostate cancer in Malaysia
title_sort synthesis of fluorine-18-labelled choline (18f-fluorocholine): towards an early and accurate management of prostate cancer in malaysia
publisher Bentham Science Publishers
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/16490/1/Synthesis%20of%20fluorine-18-labelled%20choline%20%2818F-fluorocholine%29%20towards%20an%20early%20and%20accurate%20management%20of%20prostate%20cancer%20in%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/16490/
http://benthamscience.com/journals/current-medical-imaging-reviews/volume/12/issue/1/page/67/
_version_ 1643826229217853440
score 13.211869

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