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Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation

Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, ster...

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Main Authors: Tan, Khang Wei, Tang, Siah Ying, Thomas, Renjan, Neela, Vasantha Kumari, Manickam, Sivakumar
Format: Article
Language:English
Published: Walter de Gruyter 2016
Online Access:http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf
http://psasir.upm.edu.my/id/eprint/16275/
http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml
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spelling my.upm.eprints.162752016-06-08T01:30:19Z http://psasir.upm.edu.my/id/eprint/16275/ Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation Tan, Khang Wei Tang, Siah Ying Thomas, Renjan Neela, Vasantha Kumari Manickam, Sivakumar Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, sterically stabilized nanoscale dispersion loaded with curcumin (nanodispersion) based on non-ionic colloidal system has been proposed. In this study, the process conditions were effectively optimized using response surface methodology (RSM) with Box–Behnken design (BBD). The suggested optimum formulation proved to be an excellent fit to the actual experimental output. STEM images illustrate that the optimal curcumin-loaded nanodispersion has spherical morphology with narrow particle size distribution. Particle size distribution study confirms that the solution pH does not affect the nanodispersion, and physical stability study shows that the colloidal system is stable over 90 days of storage at ambient conditions. More importantly, controlled release profile was achieved over 72 h and the in vitro drug release data fit well to Higuchi model (R2=0.9654). Walter de Gruyter 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf Tan, Khang Wei and Tang, Siah Ying and Thomas, Renjan and Neela, Vasantha Kumari and Manickam, Sivakumar (2016) Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation. Pure and Applied Chemistry, 88 (1-2). pp. 43-60. ISSN 0033-4545; ESSN: 1365-3075 http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml 10.1515/pac-2015-0601
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, sterically stabilized nanoscale dispersion loaded with curcumin (nanodispersion) based on non-ionic colloidal system has been proposed. In this study, the process conditions were effectively optimized using response surface methodology (RSM) with Box–Behnken design (BBD). The suggested optimum formulation proved to be an excellent fit to the actual experimental output. STEM images illustrate that the optimal curcumin-loaded nanodispersion has spherical morphology with narrow particle size distribution. Particle size distribution study confirms that the solution pH does not affect the nanodispersion, and physical stability study shows that the colloidal system is stable over 90 days of storage at ambient conditions. More importantly, controlled release profile was achieved over 72 h and the in vitro drug release data fit well to Higuchi model (R2=0.9654).
format Article
author Tan, Khang Wei
Tang, Siah Ying
Thomas, Renjan
Neela, Vasantha Kumari
Manickam, Sivakumar
spellingShingle Tan, Khang Wei
Tang, Siah Ying
Thomas, Renjan
Neela, Vasantha Kumari
Manickam, Sivakumar
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
author_facet Tan, Khang Wei
Tang, Siah Ying
Thomas, Renjan
Neela, Vasantha Kumari
Manickam, Sivakumar
author_sort Tan, Khang Wei
title Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
title_short Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
title_full Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
title_fullStr Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
title_full_unstemmed Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
title_sort curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
publisher Walter de Gruyter
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf
http://psasir.upm.edu.my/id/eprint/16275/
http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml
_version_ 1643826165641641984
score 13.211869

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