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A case of severe Plasmodium knowlesi in a splenectomized patient

Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for r...

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Main Authors: Boo, Yang Liang, Lim, Hong Tak, Chin, Pek Woon, Lim, Suat Yee, Hoo, Fan Kee
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf
http://psasir.upm.edu.my/id/eprint/16197/
http://www.sciencedirect.com/science/article/pii/S1383576915001671
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spelling my.upm.eprints.161972016-06-08T01:15:20Z http://psasir.upm.edu.my/id/eprint/16197/ A case of severe Plasmodium knowlesi in a splenectomized patient Boo, Yang Liang Lim, Hong Tak Chin, Pek Woon Lim, Suat Yee Hoo, Fan Kee Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for removal of parasitized red blood cells and generating immunity. We reported a case of knowlesi malaria in a non-immune, splenectomized patient. We observed the delay in parasite clearance, high parasitic counts, and severe illness at presentation. A thorough search through literature revealed several case reports on falciparum and vivax malaria in splenectomized patients. However, literature available for knowlesi malaria in splenectomized patient is limited. Further studies need to be carried out to clarify the role of spleen in host defense against human malaria especially P. knowlesi. Elsevier 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf Boo, Yang Liang and Lim, Hong Tak and Chin, Pek Woon and Lim, Suat Yee and Hoo, Fan Kee (2016) A case of severe Plasmodium knowlesi in a splenectomized patient. Parasitology International, 65 (1). pp. 55-57. ISSN 1383-5769; ESSN: 1873-0329 http://www.sciencedirect.com/science/article/pii/S1383576915001671 10.1016/j.parint.2015.10.003
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for removal of parasitized red blood cells and generating immunity. We reported a case of knowlesi malaria in a non-immune, splenectomized patient. We observed the delay in parasite clearance, high parasitic counts, and severe illness at presentation. A thorough search through literature revealed several case reports on falciparum and vivax malaria in splenectomized patients. However, literature available for knowlesi malaria in splenectomized patient is limited. Further studies need to be carried out to clarify the role of spleen in host defense against human malaria especially P. knowlesi.
format Article
author Boo, Yang Liang
Lim, Hong Tak
Chin, Pek Woon
Lim, Suat Yee
Hoo, Fan Kee
spellingShingle Boo, Yang Liang
Lim, Hong Tak
Chin, Pek Woon
Lim, Suat Yee
Hoo, Fan Kee
A case of severe Plasmodium knowlesi in a splenectomized patient
author_facet Boo, Yang Liang
Lim, Hong Tak
Chin, Pek Woon
Lim, Suat Yee
Hoo, Fan Kee
author_sort Boo, Yang Liang
title A case of severe Plasmodium knowlesi in a splenectomized patient
title_short A case of severe Plasmodium knowlesi in a splenectomized patient
title_full A case of severe Plasmodium knowlesi in a splenectomized patient
title_fullStr A case of severe Plasmodium knowlesi in a splenectomized patient
title_full_unstemmed A case of severe Plasmodium knowlesi in a splenectomized patient
title_sort case of severe plasmodium knowlesi in a splenectomized patient
publisher Elsevier
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/16197/1/A%20case%20of%20severe%20Plasmodium%20knowlesi%20in%20a%20splenectomized%20patient.pdf
http://psasir.upm.edu.my/id/eprint/16197/
http://www.sciencedirect.com/science/article/pii/S1383576915001671
_version_ 1643826141667000320
score 13.211869

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