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Molecular genetics of the developing neuroendocrine hypothalamus.

Formation of the mammalian endocrine system and neuroendocrine organs involves complex regulatory networks resulting in a highly specialized cell system able to secrete a diverse array of peptide hormones. The hypothalamus is located in the mediobasal region of the brain and acts as a gateway betwee...

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Main Authors: Szareka, Eva, Cheah , Pike See, Schwartz, Jeff, Thomas, Paul
Format: Article
Language:English
Published: Elsevier 2010
Online Access:http://psasir.upm.edu.my/id/eprint/15707/
http://www.elsevier.com
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spelling my.upm.eprints.157072013-07-03T07:33:25Z http://psasir.upm.edu.my/id/eprint/15707/ Molecular genetics of the developing neuroendocrine hypothalamus. Szareka, Eva Cheah , Pike See Schwartz, Jeff Thomas, Paul Formation of the mammalian endocrine system and neuroendocrine organs involves complex regulatory networks resulting in a highly specialized cell system able to secrete a diverse array of peptide hormones. The hypothalamus is located in the mediobasal region of the brain and acts as a gateway between the endocrine and nervous systems. From an endocrinology perspective, the parvicellular neurons of the hypothalamus are of particular interest as they function as a control centre for several critical physiological processes including growth, metabolism and reproduction by regulating hormonal signaling from target cognate cell types in the anterior pituitary. Delineating the genetic program that controls hypothalamic development is essential for complete understanding of parvicellular neuronal function and the etiology of congenital disorders that result from hypothalamic-pituitary axis dysfunction. In recent years, studies have shed light on the interactions between signaling molecules and activation of transcription factors that regulate hypothalamic cell fate commitment and terminal differentiation. The aim of this review is to summarize the recent molecular and genetic findings that have advanced our understanding of the emergence of the known important hypophysiotropic signaling molecules in the hypothalamus. We have focused on reviewing the literature that provides evidence of the dependence on expression of specific genes for the normal development and function of the cells that secrete these neuroendocrine factors, as well as studies of the elaboration of the spatial or temporal patterns of changes in gene expression that drive this development. Elsevier 2010-07 Article PeerReviewed Szareka, Eva and Cheah , Pike See and Schwartz, Jeff and Thomas, Paul (2010) Molecular genetics of the developing neuroendocrine hypothalamus. Molecular and Cellular Endocrinology, 323 (1). pp. 115-123. ISSN 0303-7207; ESSN:1872-8057 http://www.elsevier.com 10.1016/j.mce.2010.04.002 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Formation of the mammalian endocrine system and neuroendocrine organs involves complex regulatory networks resulting in a highly specialized cell system able to secrete a diverse array of peptide hormones. The hypothalamus is located in the mediobasal region of the brain and acts as a gateway between the endocrine and nervous systems. From an endocrinology perspective, the parvicellular neurons of the hypothalamus are of particular interest as they function as a control centre for several critical physiological processes including growth, metabolism and reproduction by regulating hormonal signaling from target cognate cell types in the anterior pituitary. Delineating the genetic program that controls hypothalamic development is essential for complete understanding of parvicellular neuronal function and the etiology of congenital disorders that result from hypothalamic-pituitary axis dysfunction. In recent years, studies have shed light on the interactions between signaling molecules and activation of transcription factors that regulate hypothalamic cell fate commitment and terminal differentiation. The aim of this review is to summarize the recent molecular and genetic findings that have advanced our understanding of the emergence of the known important hypophysiotropic signaling molecules in the hypothalamus. We have focused on reviewing the literature that provides evidence of the dependence on expression of specific genes for the normal development and function of the cells that secrete these neuroendocrine factors, as well as studies of the elaboration of the spatial or temporal patterns of changes in gene expression that drive this development.
format Article
author Szareka, Eva
Cheah , Pike See
Schwartz, Jeff
Thomas, Paul
spellingShingle Szareka, Eva
Cheah , Pike See
Schwartz, Jeff
Thomas, Paul
Molecular genetics of the developing neuroendocrine hypothalamus.
author_facet Szareka, Eva
Cheah , Pike See
Schwartz, Jeff
Thomas, Paul
author_sort Szareka, Eva
title Molecular genetics of the developing neuroendocrine hypothalamus.
title_short Molecular genetics of the developing neuroendocrine hypothalamus.
title_full Molecular genetics of the developing neuroendocrine hypothalamus.
title_fullStr Molecular genetics of the developing neuroendocrine hypothalamus.
title_full_unstemmed Molecular genetics of the developing neuroendocrine hypothalamus.
title_sort molecular genetics of the developing neuroendocrine hypothalamus.
publisher Elsevier
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/15707/
http://www.elsevier.com
_version_ 1643826006600974336
score 13.211869

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