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Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller

Problem Statement: Mixing filamentous fungi entails delicate balance between promoting high volumetric oxygen transfer coefficient (kLa) while keeping low hydrodynamic stresses in the microenvironment of cultures. This study examined the oxygen transfer capability of a prototype low shear helical im...

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Main Authors: Mohamed, Mohd Shamzi, Mohamad, Rosfarizan, Ramanan, Ramakrishnan Nagasundara, Abdul Manan, Musaalbakri, Ariff, Arbakariya
Format: Article
Language:English
Published: Science Publications 2009
Online Access:http://psasir.upm.edu.my/id/eprint/15664/2/ajassp.2009.848.856.pdf
http://psasir.upm.edu.my/id/eprint/15664/
http://thescipub.com/html/10.3844/ajassp.2009.848.856
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spelling my.upm.eprints.156642017-11-29T04:03:55Z http://psasir.upm.edu.my/id/eprint/15664/ Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller Mohamed, Mohd Shamzi Mohamad, Rosfarizan Ramanan, Ramakrishnan Nagasundara Abdul Manan, Musaalbakri Ariff, Arbakariya Problem Statement: Mixing filamentous fungi entails delicate balance between promoting high volumetric oxygen transfer coefficient (kLa) while keeping low hydrodynamic stresses in the microenvironment of cultures. This study examined the oxygen transfer capability of a prototype low shear helical impeller as a potential replacement for the standard Rushton turbine. Approach: The dependence of kLa upon specific power uptake, superficial gas velocity and apparent viscosity were examined under coalescent, non-coalescent and viscous pseudoplastic fluids scenario using dynamic gassing out technique. Subsequently, collected data were treated under historical data design of response surface methodology. Results: Three empirical power law kLa correlations were developed for each fluid. Correlation comparison with literature models for single turbine agitation suggest higher kLa augmentation within 1.5-3.6 folds for helical impeller in distilled water and as high as 78% improvement in electrolytes fluid. However impeller performance is comparatively 10% lower against theoretical kLa of triple turbines arrangement for power uptake between 0-1600 W m-3. In case of carboxymethylcellulose, better oxygen transfer is expected for design with higher proportionality of impeller-to-tank internal diameter. Conclusions: Helical impeller performance as gas-liquid contactor is comparable to single and triple Rushtons turbines, with superficial gas velocity proved to be more influential than power uptake in non-viscous liquids and vice versa in viscous pseudoplastic fluids. Science Publications 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15664/2/ajassp.2009.848.856.pdf Mohamed, Mohd Shamzi and Mohamad, Rosfarizan and Ramanan, Ramakrishnan Nagasundara and Abdul Manan, Musaalbakri and Ariff, Arbakariya (2009) Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller. American Journal of Applied Sciences, 6 (5). pp. 848-856. ISSN 1546-9239; ESSN: 1554-3641 http://thescipub.com/html/10.3844/ajassp.2009.848.856 10.3844/ajassp.2009.848.856
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Problem Statement: Mixing filamentous fungi entails delicate balance between promoting high volumetric oxygen transfer coefficient (kLa) while keeping low hydrodynamic stresses in the microenvironment of cultures. This study examined the oxygen transfer capability of a prototype low shear helical impeller as a potential replacement for the standard Rushton turbine. Approach: The dependence of kLa upon specific power uptake, superficial gas velocity and apparent viscosity were examined under coalescent, non-coalescent and viscous pseudoplastic fluids scenario using dynamic gassing out technique. Subsequently, collected data were treated under historical data design of response surface methodology. Results: Three empirical power law kLa correlations were developed for each fluid. Correlation comparison with literature models for single turbine agitation suggest higher kLa augmentation within 1.5-3.6 folds for helical impeller in distilled water and as high as 78% improvement in electrolytes fluid. However impeller performance is comparatively 10% lower against theoretical kLa of triple turbines arrangement for power uptake between 0-1600 W m-3. In case of carboxymethylcellulose, better oxygen transfer is expected for design with higher proportionality of impeller-to-tank internal diameter. Conclusions: Helical impeller performance as gas-liquid contactor is comparable to single and triple Rushtons turbines, with superficial gas velocity proved to be more influential than power uptake in non-viscous liquids and vice versa in viscous pseudoplastic fluids.
format Article
author Mohamed, Mohd Shamzi
Mohamad, Rosfarizan
Ramanan, Ramakrishnan Nagasundara
Abdul Manan, Musaalbakri
Ariff, Arbakariya
spellingShingle Mohamed, Mohd Shamzi
Mohamad, Rosfarizan
Ramanan, Ramakrishnan Nagasundara
Abdul Manan, Musaalbakri
Ariff, Arbakariya
Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
author_facet Mohamed, Mohd Shamzi
Mohamad, Rosfarizan
Ramanan, Ramakrishnan Nagasundara
Abdul Manan, Musaalbakri
Ariff, Arbakariya
author_sort Mohamed, Mohd Shamzi
title Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
title_short Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
title_full Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
title_fullStr Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
title_full_unstemmed Modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
title_sort modeling of oxygen transfer correlations for stirred tank bioreactor agitated with atypical helical ribbon impeller
publisher Science Publications
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/15664/2/ajassp.2009.848.856.pdf
http://psasir.upm.edu.my/id/eprint/15664/
http://thescipub.com/html/10.3844/ajassp.2009.848.856
_version_ 1643825994080976896
score 13.211869

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